The Cerebellum and Parietal Cortex Play a Specific Role in Coordination: A Pet Study

Ramnani, Narender; Toni, Ivan; Passingham, Richard E.; Haggard, Patrick

doi:10.1006/nimg.2001.0885

Cited by 78 publications

(54 citation statements)

References 41 publications

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“…Moreover, a modular organization of internal models of tool manipulation has been recently reported in the cerebellum using fMRI [Imamizu et al, 2003], extending the predictions of the MOSAIC computational model [Haruno et al, 2001;Wolpert and Kawato, 1998] from to the "motor" to the "cognitive" cerebellum. In the present study, we suggest that the vermian cerebellar activation associated with the innervatory pattern stage merely reflects its contribution to movement regulation [Deiber et al, 1996;Jueptner et al, 1996;Kitazawa, 2002] and integration of simple movements into more complex ones [Ramnani et al, 2001;Thach, 1998] during actual movement production. Rothi et al [1991Rothi et al [ , 1997b incorporated in their model the proposal presented by Roy and Square [1985] of a core conceptual, or action semantic, system that involves three kinds of knowledge: knowledge of the functions that tools and objects may serve, knowledge of actions independent of tools, and knowledge about the organization of single actions into sequences.…”

Section: Innervatory Patternsmentioning

confidence: 58%

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Peigneux

Linden

Garraux

et al. 2004

Human Brain Mapping

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Abstract:The present study aimed to ascertain the neuroanatomical basis of an influential neuropsychological model for upper limb apraxia [Rothi LJ, et al. The Neuropsychology of Action. 1997. Hove, UK: Psychology Press]. Regional cerebral blood flow was measured in healthy volunteers using H 2 15O PET during performance of four tasks commonly used for testing upper limb apraxia, i.e., pantomime of familiar gestures on verbal command, imitation of familiar gestures, imitation of novel gestures, and an action-semantic task that consisted in matching objects for functional use. We also re-analysed data from a previous PET study in which we investigated the neural basis of the visual analysis of gestures. First, we found that two sets of discrete brain areas are predominantly engaged in the imitation of familiar and novel gestures, respectively. Segregated brain activation for novel gesture imitation concur with neuropsychological reports to support the hypothesis that knowledge about the organization of the human body mediates the transition from visual perception to motor execution when imitating novel gestures [Goldenberg Neuropsychologia 1995;33:63-72]. Second, conjunction analyses revealed distinctive neural bases for most of the gesture-specific cognitive processes proposed in this cognitive model of upper limb apraxia. However, a functional analysis of brain imaging data suggested that one single memory store may be used for "to-be-perceived" and "to-be-produced" gestural representations, departing from Rothi et al.'s proposal. Based on the above considerations, we suggest and discuss a revised model for upper limb apraxia that might best account for both brain imaging findings and neuropsychological dissociations reported in the apraxia literature.

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Section: Innervatory Patternsmentioning

confidence: 58%

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Peigneux

Linden

Garraux

et al. 2004

Human Brain Mapping

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“…For example, it is easy to define the circumstances where the processes underlying visual motion detection or colour vision operate. Similarly, those working in the field of motor control often use "models of the world" deliberately designed to have characteristics close to those encountered in everyday life (see, e.g., Haggard & Richardson, 1996;Ramnani et al, 2001). However it is not at all clear which "models of the world" are represented by tasks such as the WCST.…”

Section: Argument 5 Moving Forward: What Are the Ideal Requirements mentioning

confidence: 99%

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

Burgess

Alderman

Forbes

et al. 2006

J Int Neuropsychol Soc

547

416

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This article considers the scientific process whereby new and better clinical tests of executive function might be developed, and what form they might take. We argue that many of the traditional tests of executive function most commonly in use (e.g., the Wisconsin Card Sorting Test; Stroop) are adaptations of procedures that emerged almost coincidentally from conceptual and experimental frameworks far removed from those currently in favour, and that the prolongation of their use has been encouraged by a sustained period of concentration on "construct-driven" experimentation in neuropsychology. This resulted from the special theoretical demands made by the field of executive function, but was not a necessary consequence, and may not even have been a useful one. Whilst useful, these tests may not therefore be optimal for their purpose. We consider as an alternative approach a function-led development programme which in principle could yield tasks better suited to the concerns of the clinician because of the transparency afforded by increased "representativeness" and "generalisability." We further argue that the requirement of such a programme to represent the interaction between the individual and situational context might also provide useful constraints for purely experimental investigations. We provide an example of such a programme with reference to the Multiple Errands and Six Element tests. (JINS, 2006, 12, 194-209.)

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“…The increased activation of the cerebellum is not surprising, because it is known to be involved in multilimb coordination (Debaere et al, 2001a(Debaere et al, , 2003Ramnani et al, 2001;Tracy et al, 2001;Meyer-Lindenberg et al, 2002;Ullen et al, 2003), and it becomes increasingly activated when coordination complexity rises (Ullen et al, 2003;Debaere et al, 2004). It has been hypothesized that cerebellar activity reflects increasing demands on motor timing (Ivry, 1997;Mima et al, 1999;Habas et al, 2004;Wenderoth et al, 2004b) and/or sensory processing (Jueptner et al, 1997;Bushara et al, 2001;Thickbroom et al, 2003).…”

Section: Coordination-specific Additional Activation In the Elderlymentioning

confidence: 99%

Neural Basis of Aging: The Penetration of Cognition into Action Control

Heuninckx

Wenderoth²,

Debaere³

et al. 2005

J. Neurosci.

398

319

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Although functional imaging studies have frequently examined age-related changes in neural recruitment during cognitive tasks, much less is known about such changes during motor performance. In the present study, we used functional magnetic resonance imaging to investigate age-related changes in cyclical hand and/or foot movements across different degrees of complexity. Right-handed volunteers (11 young, 10 old) were scanned while performing isolated flexion-extension movements of the right wrist and foot as well as their coordination, according to the "easy" isodirectional and "difficult" nonisodirectional mode. Findings revealed activation of a typical motor network in both age groups, but several additional brain areas were involved in the elderly. Regardless of the performed motor task, the elderly exhibited additional activation in areas involved in sensory processing and integration, such as contralateral anterior insula, frontal operculum, superior temporal gyrus, supramarginal gyrus, secondary somatosensory area, and ipsilateral precuneus. Age-related activation differences during coordination of both segments were additionally observed in areas reflecting increased cognitive monitoring of motor performance, such as the pre-supplementary motor area, pre-dorsal premotor area, rostral cingulate, and prefrontal cortex. In the most complex coordination task, the elderly exhibited additional activation in anterior rostral cingulate and dorsolateral prefrontal cortex, known to be involved in suppression of prepotent response tendencies and inhibitory cognitive control. Overall, these findings are indicative of an age-related shift along the continuum from automatic to more controlled processing of movement. This increased cognitive monitoring of movement refers to enhanced attentional deployment, more pronounced processing of sensory information, and intersensory integration.

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The Cerebellum and Parietal Cortex Play a Specific Role in Coordination: A Pet Study

Cited by 78 publications

References 41 publications

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

Imaging a cognitive model of apraxia: The neural substrate of gesture‐specific cognitive processes

The case for the development and use of “ecologically valid” measures of executive function in experimental and clinical neuropsychology

Neural Basis of Aging: The Penetration of Cognition into Action Control

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