The cerebellum and its connections to other brain structures involved in motor and non-motor functions: A comprehensive review

Prati, José Mário; Pontes-Silva, André; Gianlorenço, Anna Carolyna Lepesteur

doi:10.1016/j.bbr.2024.114933

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2024

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Cited by 3 publications

References 162 publications

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Cerebellar Roles in Motor and Social Functions and Implications for ASD

Sivalingam,

Pandian

2024

Cerebellum

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Cerebellar Roles in Motor and Social Functions and Implications for ASD

Sivalingam,

Pandian

2024

Cerebellum

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Thought for food: the endothermic brain hypothesis

Osvath,

Němec,

Brusatte

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Trends in Cognitive Sciences

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Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

Lee,

Arefin,

Gubanova

et al. 2024

Preprint

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The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the minimum requirement for these neurons is for motor coordination and not learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity inEn1/2mutants, showing that the remaining excitatory neurons lackingEn1/2exert adverse effects on extracerebellar circuits regulating motor learning and select non-motor behaviors. Thus, an absence of cerebellar output neurons is less disruptive than having cerebellar genetic mutations.

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The cerebellum and its connections to other brain structures involved in motor and non-motor functions: A comprehensive review

Cited by 3 publications

References 162 publications

Cerebellar Roles in Motor and Social Functions and Implications for ASD

Cerebellar Roles in Motor and Social Functions and Implications for ASD

Thought for food: the endothermic brain hypothesis

Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity

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