The Cerebellum and Cognitive Function: 25 Years of Insight from Anatomy and Neuroimaging

Buckner, Randy L.

doi:10.1016/j.neuron.2013.10.044

Cited by 960 publications

(749 citation statements)

References 79 publications

(93 reference statements)

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“…The cerebellum is traditionally regarded as contributing to movement planning and execution (Ito, 1984), and its role in cognitive functions is not well understood. Due to this structure's extensive connections to the cerebral cortex, including prefrontal areas (Habas et al, 2009), it has been suggested that the cerebellum may contribute to higher-level cognition, such as learning from feedback, which can support fast and adaptive control of motor behavior (Buckner, 2013;Ito, 2008;Strick et al, 2009). Hence, in the current task, the cerebellum may carry decision-relevant signals to facilitate quick motor responses.…”

Section: Discussionmentioning

confidence: 99%

Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration

et al. 2017

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A B S T R A C TReal-life decision-making often involves combining multiple probabilistic sources of information under finite time and cognitive resources. To mitigate these pressures, people "satisfice", foregoing a full evaluation of all available evidence to focus on a subset of cues that allow for fast and "good-enough" decisions. Although this form of decision-making likely mediates many of our everyday choices, very little is known about the way in which the neural encoding of cue information changes when we satisfice under time pressure. Here, we combined human functional magnetic resonance imaging (fMRI) with a probabilistic classification task to characterize neural substrates of multi-cue decision-making under low (1500 ms) and high (500 ms) time pressure. Using variational Bayesian inference, we analyzed participants' choices to track and quantify cue usage under each experimental condition, which was then applied to model the fMRI data. Under low time pressure, participants performed nearoptimally, appropriately integrating all available cues to guide choices. Both cortical (prefrontal and parietal cortex) and subcortical (hippocampal and striatal) regions encoded individual cue weights, and activity linearly tracked trial-by-trial variations in the amount of evidence and decision uncertainty. Under increased time pressure, participants adaptively shifted to using a satisficing strategy by discounting the least informative cue in their decision process. This strategic change in decision-making was associated with an increased involvement of the dopaminergic midbrain, striatum, thalamus, and cerebellum in representing and integrating cue values. We conclude that satisficing the probabilistic inference process under time pressure leads to a cortical-to-subcortical shift in the neural drivers of decisions.

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Section: Discussionmentioning

confidence: 99%

Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration

et al. 2017

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“…In 1998, the characterization of 'cerebellar cognitive affective syndrome' (CCAS) by Schmahmann and Sherman [4] extended the function of the cerebellum to the cognitive and emotional domains, demonstrating that these alterations are unrelated to cerebellar motor deficits [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

et al. 2017

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Abstract:Studies from the past three decades have demonstrated that there is cerebellar involvement in the emotional domain. Emotional processing in humans requires both unconscious and conscious mechanisms. A significant amount of evidence indicates that the cerebellum is one of the cerebral structures that subserve emotional processing, although conflicting data has been reported on its function in unconscious and conscious mechanisms. This review discusses the available clinical, neuroimaging, and neurophysiological data on this issue. We also propose a model in which the cerebellum acts as a mediator between the internal state and external environment for the unconscious and conscious levels of emotional processing.

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“…The cerebellum's role in cognitive functioning has garnered significant attention in the neuroimaging literature within recent years (Buckner, 2013;Stoodley, 2012;Stoodley and Schmahmann, 2009a;Keren-Happuch et al, 2012). Significant portions of the cerebellum map onto higher order cortical association areas, basal ganglia, thalamic, and brainstem structures (Bostan et al, 2013;Buckner et al, 2011), and congruent with this understanding, functional neuroimaging literature has demonstrated activation in the cerebellum associated with complex cognitive functions such as working memory, executive functions, and language (Kim et al, 1994;Petersen et al, 1989;Koziel et al, 2013;Stoodley and Schmahmann, 2009b).…”

Section: Discussionmentioning

confidence: 99%

IC‐P‐152: Financial literacy is associated with white matter integrity in old age

Han

Boyle

Arfanakis

et al. 2015

Alzheimer's & Dementia

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Financial literacy, the ability to understand, access, and utilize information in ways that contribute to optimal financial outcomes, is important for independence and wellbeing in old age. We previously reported that financial literacy is associated with greater functional connectivity between brain regions in old age. Here, we tested the hypothesis that higher financial literacy would be associated with greater white matter integrity in old age. Participants included 346 persons without dementia (mean age=81.36, mean education=15.39, male/female=79/267, mean MMSE=28.52) from the Rush Memory and Aging Project. Financial literacy was assessed using a series of questions imbedded as part of an ongoing decision making study. White matter integrity was assessed with diffusion anisotropy measured with diffusion tensor magnetic resonance imaging (DTI). We tested the hypothesis that higher financial literacy is associated with higher diffusion anisotropy in white matter, adjusting for the effects of age, education, sex, and white matter hyperintense lesions. We then repeated the analysis also adjusting for cognitive function. Analyses revealed regions with significant positive associations between financial literacy and diffusion anisotropy, and many remained significant after accounting for cognitive function. White matter tracts connecting right hemisphere temporal-parietal brain regions were particularly

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The Cerebellum and Cognitive Function: 25 Years of Insight from Anatomy and Neuroimaging

Cited by 960 publications

References 79 publications

Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration

Probabilistic inference under time pressure leads to a cortical-to-subcortical shift in decision evidence integration

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

IC‐P‐152: Financial literacy is associated with white matter integrity in old age

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