The cerebellar (para)flocculus: A review on its auditory function and a possible role in tinnitus

Mennink, Lilian M.; Dijk, J. Marc C. van; Dijk, Pim van

doi:10.1016/j.heares.2020.108081

Cited by 23 publications

(19 citation statements)

References 85 publications

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“…It has been demonstrated that the cerebellum participates in and regulates pain perception ( Moulton et al, 2010 ). Moreover, previous studies also indicated the possible relationships between the cerebellum (paraflocculus) and the tinnitus mechanism ( Chen et al, 2017b ; Mennink et al, 2020 ). Therefore, we suggest that the cerebellar network may play a core role in patients with migraine along with tinnitus.…”

Section: Discussionmentioning

confidence: 87%

Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus

Lan

Liu

Xǔ

et al. 2022

Front. Aging Neurosci.

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PurposeThe possible relationship between migraine and tinnitus still remains elusive although migraine is often accompanied by chronic tinnitus. Several neuroimaging studies have reinforced the cognitive network abnormality in migraine and probably as well as tinnitus. The present work aims to investigate the dynamic neurocognitive network alterations of migraine comorbid with tinnitus.Materials and MethodsParticipants included migraine patients (n = 32), tinnitus patients (n = 20), migraine with tinnitus (n = 27), and healthy controls (n = 47), matched for age and gender. Resting-state functional magnetic resonance imaging (rs-fMRI) with independent component analysis (ICA), sliding window cross-correlation, and clustering state analysis was used to detect the dynamic functional network connectivity (dFNC) of each group. Correlation analyses illustrated the association between clinical symptoms and abnormal dFNC in migraine as well as tinnitus.ResultsCompared with healthy controls, migraine patients exhibited decreased cerebellar network and visual network (CN-VN) connectivity in State 2; migraine with tinnitus patients showed not only decreased CN-VN connectivity in State 2 but also decreased cerebellar network and executive control network (CN-ECN) connectivity in State 2 and increased cerebellar network and somatomotor network (SMN-VN) connectivity in State 1. The abnormal cerebellum dFNC with the executive control network (CN-ECN) was negatively correlated with headache frequency of migraine (rho = −0.776, p = 0.005).ConclusionBrain network characteristics of migraine with tinnitus patients may indicate different mechanisms for migraine and tinnitus. Our results demonstrated a transient pathologic state with atypical cerebellar-cortical connectivity in migraine with tinnitus patients, which might be used to identify the neuro-pathophysiological mechanisms in migraine accompanied by tinnitus.

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Section: Discussionmentioning

confidence: 87%

Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus

Lan

Liu

Xǔ

et al. 2022

Front. Aging Neurosci.

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“…In some anatomical literature this opening is referred to as the subarcuate fossa which is only supposed to contain the fl occulus at a young age and transitions to only containing a vein later in life. Due to the diff erences in cerebellar surface anatomy in carnivores, a more incompassing name should be the cerebellar fossa (NAV, 2017;IVAN, 2018;Hermanson et al, 2020;Mennink et al, 2020). Fundus meatus acustici interni (Fundus of the internal acoustic meatus) (NAV, 2017;IVAN;2018;Hermanson et al, 2020) Th e fl oor of the internal acoustic meatus (IVAN, 2018).…”

Section: Fenestra Vestibuli (Vestibular Window Oval Window)mentioning

confidence: 99%

Can You Hear Me Now? A Comparative Survey of Pinniped Auditory Apparatus Morphology

Koper

Koretsky

Rahmat³

2021

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Over the past century research on the morphology of the auditory apparatuses of pinnipeds, which include Phocidae (true seals), Otariidae (sea lions and fur seals), and Odobenidae (walruses) is extremely limited, in comparison to other Carnivora. Although, the auditory region and surrounding basicrania are areas that are evolutionarily conservative, most literature is unclear due to mixed terminology, inaccurate information, and indistinct, outdated illustrations. Th e lack of adequate and current studies demonstrates the need for compiling morphological information of the auditory region of modern carnivores in relation to hearing. Auditory terminology will be explored to show morphological comparisons and naming practices among the carnivoran families. By streamlining accurate terminology with straightforward illustrations, the behavioral information gleaned from auditory morphological structures will be clearer even among the diverse members of Carnivora. Th is initial assessment will detail the limited information in prior research on the hearing adaptations for transitional semiaquatic carnivores. Th is preliminary review will help to establish the adaptive patterns (from land to sea) in the basicranial morphology of early pinnipeds, especially in phocids.

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“…It appears that the ventral PFL in animals corresponds to the human accessory PFL, but this is still a matter of debate (Figure 1). Likewise, the dorsal PFL in animals seems to correspond to the human cerebellar tonsil, and some reports even include the biventral lobule (Voogd and Ruigrok, 2012;Mennink et al, 2020). Rarely, animal studies on auditory function or tinnitus distinguish between the ventral and dorsal PFL.…”

Section: Introductionmentioning

confidence: 99%

“…This modulation may occur via an auditory feedback loop between the auditory cortex and the PFL. This feedback loop may become more activated when tinnitus exists, and intervention within this feedback loop may modulate tinnitus (Mennink et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cerebellar Gray Matter Volume in Tinnitus

et al. 2022

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Tinnitus is the perception of sound without an external source. The flocculus (FL) and paraflocculus (PFL), which are small lobules of the cerebellum, have recently been implicated in its pathophysiology. In a previous study, the volume of the (P)FL-complex correlated with tinnitus severity in patients that had undergone cerebellopontine angle (CPA) tumor removal. In this study, the relation between tinnitus and gray matter volume (GMV) of the (P)FL-complex, GMV of the other cerebellar lobules and GMV of the cerebellar nuclei is investigated in otherwise healthy participants. Data was processed using the SUIT toolbox, which is dedicated to analysis of imaging data of the human cerebellum. GMV of all cerebellar lobules and nuclei were similar between tinnitus and non-tinnitus participants. Moreover, no relation was present between tinnitus severity, as measured by the Tinnitus Handicap Inventory, and (P)FL-complex GMV, tonsil GMV, or total cerebellar cortical GMV. These results suggest that in otherwise healthy participants, in contrast to participants after CPA tumor removal, no relation between the GMV of neither the (P)FL-complex nor other cerebellar lobules and tinnitus presence and severity exists. These findings indicate that a relation only exists when the (P)FL-complex is damaged, for instance by a CPA tumor. Alternatively, it is possible that differences in (P)FL-complex GMVs are too small to detect with a voxel-based morphometry study. Therefore, the role of the (P)FL-complex in tinnitus remains to be further studied.

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The cerebellar (para)flocculus: A review on its auditory function and a possible role in tinnitus

Cited by 23 publications

References 85 publications

Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus

Aberrant Modulations of Neurocognitive Network Dynamics in Migraine Comorbid With Tinnitus

Can You Hear Me Now? A Comparative Survey of Pinniped Auditory Apparatus Morphology

Cerebellar Gray Matter Volume in Tinnitus

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