The Cephalogastric Phase of the Pancreatic Response to Food in the Dog

Cd, Johnson; Ma, Daifu; Mj, Treffot; Sarles, H

doi:10.1097/00006676-199103000-00010

Cited by 7 publications

(3 citation statements)

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“…Hickson (1970) showed that, in the pig, atropine was effective in blocking only the protein secretion, leaving the serous component unaffected. Subsequently, an atropine-resistant serous component has been identified in the pancreatic secretions of the cat (Lenninger & Ohlin, 1971) and the dog (Johnson, Devaux, Treffot & Sarles, 1991). These studies indicate that, as well as acetylcholine, an atropine-resistant vagal neurotransmitter is released which evokes the serous secretion.…”

Section: Introductionmentioning

confidence: 95%

An investigation into the relative merits of pituitary adenylate cyclase‐activating polypeptide (PACAP‐27) and vasoactive intestinal polypeptide as vagal neuro‐transmitters in exocrine pancreas of rats

Wheeler

Eardley²,

Mcnulty³

et al. 1997

Experimental Physiology

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SUMMARYPancreatic exocrine secretions were collected over 15 min periods and analysed in terms of weight of juice, total HCO3-and total protein in anaesthetized and pithed rats. Pituitary adenylate cyclase-activating polypeptide (PACAP) (i.v.) evoked a serous HCO3-secretion which contained relatively little protein, together with a marked vasodepressor action. The latter was still maximal at lower doses of PACAP, which evoked diminished pancreatic secretions. The effects of PACAP were similar to those evoked by the same dose of VIP and by cervical vagal stimulation, while secretin evoked a much larger secretion of fluid and HCO3-. The time courses of the PACAPevoked secretions were significantly delayed compared with those of VIP. In the pithed rat, PACAP caused the same level of pancreatic secretions as in the anaesthetized rat, though this was now accompanied by a substantial pressor response which was blocked by phentolamine or prazosin, indicating that it was a -adrenoceptor mediated. VIP caused a depressor response in the pithed rat, as well as the same level of pancreatic secretions as in the anaesthetized rat. The putative VIP antagonist [Lys',Pro25,Arg3'4,Tyr6]-VIP (abbreviated as VIPi) caused a selective and significant reduction in the HCO3-secretion evoked by VIP and blocked the vasodepressor response caused by VIP. By contrast, VIPi did not antagonize either the secretory or vasodepressor actions of PACAP. Unilateral electrical stimulation of the cervical vagus nerve evoked significant increases in the weight of juice, total protein and total HC03-secreted. When preceded by injection of VIPi, vagally evoked secretions were unchanged in terms of weight of juice and total protein but had a significantly reduced HCO3 content. These results are consistent with the release of VIP, though not PACAP, as a vagal neurotransmitter in the exocrine pancreas.

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Section: Introductionmentioning

confidence: 95%

An investigation into the relative merits of pituitary adenylate cyclase‐activating polypeptide (PACAP‐27) and vasoactive intestinal polypeptide as vagal neuro‐transmitters in exocrine pancreas of rats

Wheeler

Eardley²,

Mcnulty³

et al. 1997

Experimental Physiology

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“…Distention at the gastric antrum elicits pancreatic enzyme secretion by activation of a vago-vagal reflex called the antro-pancreatic reflex ( 26 ). The antro-pancreatic reflex is an important component of the gastric phase of pancreatic secretion ( 27 ).…”

Section: Physiology and Regulation Of Pancreatic Secretionmentioning

confidence: 99%

Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing

et al. 2022

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The exocrine pancreas plays an important role in digestion. Understanding of the physiology and regulation of exocrine function provides insight into disease processes and basis of functional testing. Specifically, exocrine pancreatic insufficiency (EPI) can cause maldigestion and thus a proper assessment of exocrine pancreatic function is important. There are indirect and direct methods for evaluating pancreatic function. Indirect methods are varied and include stool, serum, urine, and breath tests. Fecal elastase is a commonly used indirect test today. Direct methods involve stimulated release of pancreatic fluid that is collected from the duodenum and analyzed for enzyme activity. The most used direct test today is the endoscopic pancreatic function test. Indirect pancreatic function testing is limited in identifying cases of mild to moderate EPI, and as such in these cases, direct testing has higher sensitivity and specificity in diagnosing EPI. This review provides a comprehensive guide to indirect and direct pancreatic function tests as well as an in-depth look at exocrine pancreatic function including anatomy, physiology, and regulatory mechanisms.

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“…By ensuring free flow through the pancreatic duct by flushing through with saline, an atropine-resistant vagally evoked serous secretion was described in the cat by Lenninger & Ohlin (1971). Resistance of the vagally evoked fluid secretion to atropine has also now been described in the dog (Johnson, Devaux, Treffot & Sarles, 1991).…”

Section: Introductionmentioning

confidence: 99%

Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.

Barrett

McDougall

Morrison

1993

The Journal of Physiology

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SUMMARY1. Pancreatic secretions were collected in response to 15 min periods of bilateral stimulation of the cervical vagus nerves in the pithed rat.2. The weight of juice, total HC03-and total protein evoked by a second period of vagal stimulation were essentially similar to those of the first period of vagal stimulation.3. When the second period of vagal stimulation was preceded by an intravenous bolus injection of atropine sufficient to block the vagally induced bradycardia, the weight of secretion and total protein were greatly potentiated over an extended time course far exceeding that of the period of vagal stimulation. Total HC03-was unchanged.4. By contrast, atropine was effective in antagonizing the stimulatory effects of the muscarinic agonist methacholine injected intravenously.5. The putative VIP (vasoactive intestinal polypeptide) antagonist [D-p-chloroPhe6, Leul7]-VIP injected intravenously also increased the vagally evoked weight of juice, with total HCO,3-and total protein unchanged. This was explicable by a partial agonist effect which was additive to the stimulatory action of vagal stimulation.6. To explain these results, it is proposed that endogenously released acetylcholine exerts a negative feedback effect on the postganglionic varicosities which release both acetylcholine and another cotransmitter which was not excluded as being VIP. In the presence of atropine, the cotransmitter is proposed to be released from the inhibitory feedback, thus enhancing the response to vagal stimulation.

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The Cephalogastric Phase of the Pancreatic Response to Food in the Dog

Cited by 7 publications

References 0 publications

An investigation into the relative merits of pituitary adenylate cyclase‐activating polypeptide (PACAP‐27) and vasoactive intestinal polypeptide as vagal neuro‐transmitters in exocrine pancreas of rats

An investigation into the relative merits of pituitary adenylate cyclase‐activating polypeptide (PACAP‐27) and vasoactive intestinal polypeptide as vagal neuro‐transmitters in exocrine pancreas of rats

Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing

Enhancement by atropine of the pancreatic exocrine secretions evoked by vagal stimulation in the pithed rat.

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