The Central (Spinal) Canal in Congenital Murine Hydrocephalus: Morphological and Physiological Aspects

Kuwamura, Keiichi; McLone, David G.; Raimondi, Anthony J.

doi:10.1159/000119779

Cited by 10 publications

(4 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes are similar regardless of the cause of hydrocephalus [1], being induced mainly by increased intraventricular pressure. In the spinal central canal, however, the ependyma may be exposed to a variety of cerebrospinal fluid pressures depending on the cause of hydrocephalus, resulting in different ependymal abnormalities according to the pathogenesis of ventricular dilatation [16,19,20,22,29,40].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of nestin and vimentin in the ependyma of spinal cords from hydrocephalic infants

Takano¹,

Becker²

1997

Neuropathol Appl Neurobiol

View full text Add to dashboard Cite

The ependyma of the spinal central canal in cases of hydrocephalus shows abnormalities which vary with the aetiology of ventricular dilatation. To determine whether these ependymal changes are developmental or reactive in nature, immunohistochemical findings were compared between nine normal controls and 12 cases of hydrocephalus (three each of congenital aqueductal stenosis. Dandy-Walker malformation, Chiari type II malformation, and post-haemorrhagic hydrocephalus) using antisera to nestin, vimentin and glial fibrillary acidic protein. The main pathological findings were disruption of ependymal layer, apparent pseudostratification of ependyma, expansion, cleft or syrinx formation in relation to the central canal, and ependymal rosette formation. In normal developing fetal spinal cord, nestin and vimentin were expressed mainly in pseudostratified ependymal cells and radial fibres in the median septum. In cases with congenital hydrocephalus (congenital aqueductal stenosis. Dandy-Walker malformation, and Chiari type II malformation), nestin was overexpressed in immature ependymal cells, and strong vimentin immunoreactivity was detected in the long tract of radial fibres in the median septum. Nestin and vimentin were also expressed in small cells and their fibres which covered areas denuded of ependymal cells in cases of Chiari type II malformation and post-haemorrhagic hydrocephalus. Two conclusions are suggested by this report. First, the ependyma of the spinal central canal in congenital hydrocephalus shows a delay in maturation of radial glial cells into mature astrocytes and ependymal cells. Second, areas of ependymal denudation may be repaired by the immature glial cells derived from subependymal cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Overexpression of nestin and vimentin in the ependyma of spinal cords from hydrocephalic infants

Takano¹,

Becker²

1997

Neuropathol Appl Neurobiol

View full text Add to dashboard Cite

show abstract

“…Neither author cited specific information regarding the histologie findings or details of the selection process that resulted in this animal model of syringomyelia. Kuwamura et al (1978) reported the morphologic and physiologic aspects of the dilated central canal in congenitally hydrocéphalie mice. Although the animals' short life span limited their use as a model of human syringomyelia, histopathologic examination of the spinal cord subependymal tissue layers after intrathecal injection of ferritin suggested that the increased extracellular space in this area was the result of the increased CSF hydrodynamics.…”

Section: Histopathology and Pathogenesis Of Syringomyeliamentioning

confidence: 99%

Syringomyelia: Clinical Observations and Experimental Studies

Madsen

Yezierski²,

Holets³

1994

Journal of Neurotrauma

View full text Add to dashboard Cite

Although cavitary lesions of the spinal cord have been recognized for centuries, only recently have effective, noninvasive imaging techniques allowed antemortem diagnosis of this clinical syndrome. Methods of treatment have not been consistently successful in alleviating or reversing the clinical symptoms caused by these cystic lesions. Incomplete understanding of the underlying pathologic basis for the syringes has impeded the development of effective methods of treatment. This review documents historical considerations regarding clinical observations and experimental studies of this entity and the animal models that have been reported for each of the major types of syringomyelia. Recent studies have suggested that development of a relevant animal model of posttraumatic syringomyelia is imminent. Successful development of an experimental model will not only permit definition of the pathogenesis of cyst formation but also provide methods for testing of therapeutic interventions.

show abstract

“…Changes in the central canal of the spinal cord are correlated with events occurring in the intracranial compartment [2]. The central canal enlarges and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as these events take place within the ventricular system ( fig.…”

Section: The Central Canal In Murine Hydrocephalusmentioning

confidence: 99%

Cerebrospinal Fluid Pathways in a Murine Mutant

McLone¹

1979

Pediatr Neurosurg

Self Cite

View full text Add to dashboard Cite

The hy-3/hy-3 mouse is a model of congenital hydrocephalus. The development of the subarachnoid space and extracellular space were studied in normal and hydro-cephalic animals. A previous space in the mesenchyme is altered to form the subarachnoid space. Changes in the extracellular space demonstrate that this space is dynamic and acts to compensate for events occurring in the ventricular system. The aqueduct and central spinal canal are also involved in the hydrocephalic process. Change in cerebral vasculature may indicate the processes which lead to irreversibility.

show abstract

The Central (Spinal) Canal in Congenital Murine Hydrocephalus: Morphological and Physiological Aspects

Cited by 10 publications

References 14 publications

Overexpression of nestin and vimentin in the ependyma of spinal cords from hydrocephalic infants

Overexpression of nestin and vimentin in the ependyma of spinal cords from hydrocephalic infants

Syringomyelia: Clinical Observations and Experimental Studies

Cerebrospinal Fluid Pathways in a Murine Mutant

Contact Info

Product

Resources

About