The central pattern of weakness of ALS: Morphological correlates in whole‐body muscle MRI
Nathalie Wimmer,
Hans‐Peter Müller,
Patrick Metze
et al.
Abstract:ObjectiveMonosynaptically cortically innervated α‐motoneurons are early and strongly involved in amyotrophic lateral sclerosis (ALS). Consequently, the muscles that receive the strongest direct corticomotoneuronal input are the clinically most affected. To objectify this concept in vivo through morphological image correlates, whole‐body magnetic resonance imaging (MRI) with muscle signal analysis was performed in patients with ALS compared to healthy controls.MethodsModified Dixon‐based whole‐body MRI was acqu… Show more
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