The Central Nervous System of Invertebrates

Hartenstein, Volker

doi:10.1002/9781118316757.ch8

Cited by 1 publication

(1 citation statement)

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“…All synapses observed in our FIB-SEM data sets were polyadic, i.e. each presynaptic site connected to multiple postsynaptic sites (See example in Figure 1E ), a feature of insect brain synapses (Meinertzhagen and O’Neil, 1991;Malun et al, 1993;Prokop and Meinertzhagen, 2006;Hartenstein, 2016;Rybak et al, 2016). Some synaptic complexes had up to 16 postsynaptic sites ( Figure 2 – figure supplement 1B ), i.e.…”

Section: Resultsmentioning

confidence: 99%

The unique synaptic circuitry of specialized olfactory glomeruli inDrosophila melanogaster

Gruber

Cantera

Pleijzier

et al. 2022

Preprint

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To manage the great complexity of detecting and identifying olfactory cues, the insect olfactory system has evolved two main strategies: combinatorial coding and specialized, narrowly tuned olfactory pathways. In combinatorial coding, odorants are encoded by activation of multiple, broadly tuned olfactory sensory neurons that innervate distinct sets of glomeruli. In specialized olfactory pathways, information regarding a single or a few odorants is processed in a discrete, narrowly tuned circuit within a dedicated glomerulus. Here, we compared the narrowly tuned glomerulus DA2 with the broadly tuned glomerulus DL5 at the ultrastructural level, by using volume based focused ion beam scanning electron microscopy. We provide a detailed analysis of neuronal innervation, synaptic composition as well as a circuit diagram of the major glomerular cell types: olfactory sensory neurons (OSNs), uniglomerular projection neurons (uPNs) and multiglomerular neurons (MGNs). By comparing our data with a previously mapped narrowly tuned glomerulus (VA1v), we disclose putative generic features of narrowly tuned glomerular circuits: a high density of neuronal fibers and synapses, a low degree of sensory lateralization, strong axo-axonic connections between OSNs as well as dendro-dendritic connections between uPNs, and a low degree of presynaptic inhibition at the OSN axons. We also show a unique property of the large uPN dendrite in DL5, which forms substantial amount of autapses.

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