The Central Nervous System in Potassium Homeostasis

Rabinowitz, L.; Айзман, Р. И.

doi:10.1006/frne.1993.1001

Cited by 21 publications

(19 citation statements)

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“…Study 2 examined the effects of dietary K ϩ intake on plasma levels of gut peptides known to regulate renal function, including GLP-1, GIP, guanylin, and uroguanylin (1,8,20,23,28). We tested whether the plasma concentrations of any of these gut peptides changed in response to dietary K ϩ intake, a necessary condition for a role in the gut factor effects.…”

Section: Animalsmentioning

confidence: 99%

“…We tested whether the plasma concentrations of any of these gut peptides changed in response to dietary K ϩ intake, a necessary condition for a role in the gut factor effects. We also examined the effects of dietary K ϩ intake on plasma levels of pituitary peptides, such as AVP, ␣-MSH, and ␥-MSH, and aldosterone, which have been implicated in K ϩ homeostasis (23). Food was removed at 1700 on the day before the experiment.…”

Section: Animalsmentioning

confidence: 99%

“…We next tested whether consuming a K ϩ -containing diet was associated with changes in circulating hormones secreted by the gut, such as GLP-1, GIP, guanylin, and uroguanylin, as these peptide hormones have been implicated in K ϩ and/or Na ϩ homeostasis (1,8,20,23,28). We were particularly interested in testing the incretin hormones (i.e., GLP-1 and GIP) as a gut factor, based on the concept that K ϩ sensing may occur during meal ingestion, but not in the fasting state (see DISCUSSION).…”

Section: Effects Of Dietary Kmentioning

confidence: 99%

“…However, similar effects were also seen with the extracts of pituitary from overnight-fasted rats (i.e., without feeding or K ϩ intake), indicating that the kaliuretic substances were present in the pituitary independent of dietary K ϩ intake. We also examined whether consuming a K ϩ -containing diet was associated with changes in circulating pituitary hormones, such as AVP, ␣-MSH, and ␥-MSH, which have been implicated in K ϩ and/or Na ϩ homeostasis (23). Plasma levels of AVP, ␣-MSH, and ␥-MSH were not changed either by meal feeding or dietary K ϩ content (Fig.…”

Section: R424mentioning

confidence: 99%

“…In the present study, we aimed to discriminate between these two potential mechanisms to stimulate renal K ϩ excretion after normal dietary K ϩ intake. In addition, we tested for the role of putative humoral factors that could mediate the gut factor effects, including gut peptides, such as glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), guanylin, and uroguanylin, and pituitary peptides, such as AVP, ␣-MSH, ␥-MSH, all of which have been implicated in the regulation of Na ϩ or K ϩ excretion or other kidney function (1,8,20,23,28).…”

mentioning

confidence: 99%

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Gut sensing of dietary K⁺ intake increases renal K⁺ excretion

Kim

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

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Dietary K+ intake may increase renal K+ excretion via increasing plasma [K+] and/or activating a mechanism independent of plasma [K+]. We evaluated these mechanisms during normal dietary K+ intake. After an overnight fast, [K+] and renal K+ excretion were measured in rats fed either 0% K+ or the normal 1% K+ diet. In a third group, rats were fed with the 0% K+ diet, and KCl was infused to match plasma [K+] profile to that of the 1% K+ diet group. The 1% K+ feeding significantly increased renal K+ excretion, associated with slight increases in plasma [K+], whereas the 0% K+ diet decreased K+ excretion, associated with decreases in plasma [K+]. In the KCl-infused 0% K+ diet group, renal K+ excretion was significantly less than that of the 1% K+ group, despite matched plasma [K+] profiles. We also examined whether dietary K+ alters plasma profiles of gut peptides, such as guanylin, uroguanylin, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide, pituitary peptides, such as AVP, α-MSH, and γ-MSH, or aldosterone. Our data do not support a role for these hormones in the stimulation of renal K+ excretion during normal K+ intake. In conclusion, postprandial increases in renal K+ excretion cannot be fully accounted for by changes in plasma [K+] and that gut sensing of dietary K+ is an important component of the regulation of renal K+ excretion. Our studies on gut and pituitary peptide hormones suggest that there may be previously unknown humoral factors that stimulate renal K+ excretion during dietary K+ intake.

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