We consider estimation and confidence regions for the parameters : and ; based on the observations (X 1 , Y 1 ), ..., (X n , Y n ) in the errors-in-variables model X i = Z i +e i and Y i =:+;Z i + f i for normal errors e i and f i of which the covariance matrix is known up to a constant. We study the asymptotic performance of the estimators defined as the maximum likelihood estimator under the assumption that Z 1 , ..., Z n is a random sample from a completely unknown distribution. These estimators are shown to be asymptotically efficient in the semi-parametric sense if this assumption is valid. These estimators are shown to be asymptotically normal even in the case that Z 1 , Z 2 , ... are arbitrary constants satisfying a moment condition. Similarly we study the confidence regions obtained from the likelihood ratio statistic for the mixture model and show that these are asymptotically consistent both in the mixture case and in the case that Z 1 , Z 2 , ... are arbitrary constants.1996 Academic Press, Inc.