The central effects of buspirone on abdominal pain in rats

Panteleev, S. S.; Sivachenko, Ivan B.; Lyubashina, O. A.

doi:10.1111/nmo.13431

Cited by 10 publications

(6 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The buspirone‐produced reduction in the CRD‐evoked excitation of the CVLM neurons and blood pressure response to CRD that we observed in healthy control animals is in accordance with our previous findings, demonstrating similar manifestations of visceral antinociceptive properties of the drug in normal conditions (Panteleev et al, 2018, 2021). In turn, the suppressive action of the compound on the visceromotor reactions to CRD, we showed in the control rats, is in agreement with our previous study in dogs (Lyubashina et al, 2017) and other studies reporting analgesic effect of buspirone and another 5‐HT1A agonist, 8‐OH‐DPAT in conscious animals (Abdel Salam & Baiuomy, 2007; Danzebrink & Gebhart, 1991; Galeotti et al, 1997; Korzeniewska‐Rybicka & Płaźnik, 2001; Rouzade et al, 1998; Sivarao et al, 2004).…”

Section: Discussionsupporting

confidence: 93%

“…In particular, 5-HT1A agonists have been shown to produce antinociceptive effects in various visceral pain models in rodents (Abdel Salam & Baiuomy, 2007;Danzebrink & Gebhart, 1991;Galeotti et al, 1997;Korzeniewska-Rybicka & Płaźnik, 2001;Rouzade et al, 1998;Sivarao et al, 2004). In line with these findings, we previously demonstrated that buspirone, a partial agonist of 5-HT1A receptors, dose dependently inhibited visceromotor reactions and medullary neuronal responses to noxious colorectal distension in healthy awake dogs and anesthetized rats Panteleev et al, 2018Panteleev et al, , 2021. However, in other studies 5-HT1A receptor activation led to pronociceptive effect (Coelho et al, 2001;Mickle et al, 2012), whereas 5-HT1A antagonists attenuated visceral pain perception (Coelho et al, 1998;Lindström et al, 2009).…”

Section: Introductionsupporting

confidence: 69%

“…The observed changes in the medullary neuronal activity may equally be an immediate consequence of buspirone‐induced suppression of the CVLM nociceptive cells or a secondary result of its action on other brain and spinal sites. Considering our previous findings that visceral pain‐related effects of the compound within the caudal medulla are largely mediated by supraspinal 5‐HT1A‐dependent mechanisms (Panteleev et al, 2018, 2021), a site for such modulation is assumed to be immediately within the CVLM, where the 5‐HT1A receptors have been localized (Helke et al, 1997; Liu & Wong‐Riley, 2010; Pazos & Palacios, 1985). It seems reasonable to assume that their activation by buspirone can lead to a reduction in the excitatory serotonergic and glutamatergic neurotransmissions operating in the region (Fonseca et al, 2001; Izzo et al, 1993; Li et al, 2020; Steinbusch, 1981; Suzuki et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Opposing effects of 5‐HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats

Lyubashina,

Sivachenko,

Sushkevich

et al. 2023

J of Neuroscience Research

View full text Add to dashboard Cite

The serotonergic 5‐HT1A receptors are implicated in the central mechanisms of visceral pain, but their role in these processes is controversial. Considering existing evidences for organic inflammation‐triggered neuroplastic changes in the brain serotonergic circuitry, the ambiguous contribution of 5‐HT1A receptors to supraspinal control of visceral pain in normal and post‐inflammatory conditions can be assumed. In this study performed on male Wistar rats, we used microelectrode recording of the caudal ventrolateral medulla (CVLM) neuron responses to colorectal distension (CRD) and electromyography recording of CRD‐evoked visceromotor reactions (VMRs) to evaluate post‐colitis changes in the effects of 5‐HT1A agonist buspirone on supraspinal visceral nociceptive transmission. In rats recovered from trinitrobenzene sulfonic acid colitis, the CRD‐induced CVLM neuronal excitation and VMRs were increased compared with those in healthy animals, revealing post‐inflammatory intestinal hypersensitivity. Intravenous buspirone (2 and 4 mg/kg) under urethane anesthesia dose‐dependently suppressed CVLM excitatory neuron responses to noxious CRD in healthy rats, but caused dose‐independent increase in the already enhanced nociceptive activation of CVLM neurons in post‐colitis animals, losing also its normally occurring faciliatory effect on CRD‐evoked inhibitory medullary neurotransmission and suppressive action on hemodynamic reactions to CRD. In line with this, subcutaneous injection of buspirone (2 mg/kg) in conscious rats, which attenuated CRD‐induced VMRs in controls, further increased VMRs in hypersensitive animals. The data obtained indicate a shift from anti‐ to pronociceptive contribution of 5‐HT1A‐dependent mechanisms to supraspinal transmission of visceral nociception in intestinal hypersensitivity conditions, arguing for the disutility of buspirone and possibly other 5‐HT1A agonists for relieving post‐inflammatory abdominal pain.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Opposing effects of 5‐HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats

Lyubashina,

Sivachenko,

Sushkevich

et al. 2023

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…In the ACC, there are many subtypes of serotonin receptors. According to previous reports, 5-HT1A and 5-HT7 receptors play important roles in pain conditions (15,30,47). Therefore, to further explore ACC downstream targets for increased release of serotonin induced by exercise, we conducted further studies on 5-HT1A and 5-HT7 receptors.…”

Section: Discussionmentioning

confidence: 99%

Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex

Zhou

Meng

Cui

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

View full text Add to dashboard Cite

PurposeClinical studies found that regular aerobic exercise has analgesic and antianxiety effects; however, the underlying neural mechanisms remain unclear. Multiple studies have suggested that regular aerobic exercise may exert brain-protective effects by promoting the release of serotonin, which may be a pain modulator. Anterior cingulate cortex (ACC) is a key brain area for pain information processing, receiving dense serotonergic innervation. As a result, we hypothesized that exercise may increase the release of serotonin in the ACC, thus improving pain and anxiety behaviors.MethodsIntegrative methods were used, including behavioral, electrophysiological, pharmacological, biochemical, and genetic approaches, to explore the effects of regular aerobic exercise and the underlying neural mechanisms.ResultsRegular aerobic exercise in the form of voluntary wheel running for 30 min daily for 15 d showed significant effectiveness in relieving pain and concomitant anxiety in complete Freund’s adjuvant–induced chronic inflammation pain models. c-Fos staining and multielectrode array recordings revealed alterations in neuronal activities and synaptic plasticity in the ACC. Moreover, systemic pharmacological treatment with 4-chloro-dl-phenylalanine (PCPA) to deplete endogenous serotonin and local delivery of serotonin to the ACC revealed that exercise-related serotonin release in the ACC bidirectionally modulates pain sensitization and anxiety behaviors by modulating synaptic plasticity in the ACC. Furthermore, we found that 5-HT1A and 5-HT7 receptors mediated the serotonin modulation effects under conditions of regular aerobic exercise through local infusion of a selective antagonist and shRNA in the ACC.ConclusionsOur results reveal that regular aerobic exercise can increase serotonin release and modulate synaptic plasticity in the ACC, ultimately improving pain and concomitant anxiety behaviors through the functions of the 5-HT1A and 5-HT7 receptors.

show abstract

“…Several published controlled studies have evaluated amitriptyline, citalopram, duloxetine and other antidepressants in adults, which generally support efficacy in both neuropathic and non-neuropathic pain, with the effect being greater for tricyclic antidepressants and serotonin-norepinephrine reuptake inhibitors than serotonin-specific reuptake inhibitors. 29 , 30 For buspirone, although preclinical studies demonstrate antinociceptive effects, 31 , 32 the clinical evidence supporting benefit is weak. 33 In our study, we also observed that without buspirone, pooled effect was greater and more significant.…”

Section: Discussionmentioning

confidence: 99%

Are Psychotropic Medications Effective in Chronic Pain Management in Children and Adolescents? A Meta-Analysis of Randomized Control Trials

Jolly

Mansuri

Trivedi

et al. 2021

JPR

View full text Add to dashboard Cite

Objective Data defining and subsequently guiding the use of psychotropic medications in children and adolescents is sparse. We conducted a meta-analysis of randomized control trials to examine the effectiveness of psychotropic medications in children and adolescents with chronic pain. Methods We conducted a comprehensive literature search from published studies, and annual scientific sessions of psychiatry conferences. We identified double-blind, randomized control trials (RCTs) in which psychotropic medications were compared to placebo. Data was collected for the total number of patients, baseline characteristics, and changes in pain score. Meta-analysis was performed using a random effect model evaluating average change in pain score and the number of patients with a reduction in pain score for both groups. Pooled data are expressed as standardized mean differences (SMD) and odds ratios (OR) with 95% confidence intervals (CI). Results We found 5 studies that included amitriptyline (n=2), citalopram (n=1), buspirone (n=1) and duloxetine (n=1). In the pooled analysis for the difference in the average change in pain score, 4 RCTs with 395 patients were included. After 12–13 weeks of therapy, reductions in pain score were significantly greater in the psychotropic drug group as compared to placebo (SMD: −0.77, 95% CI −1.54, 0.0001, p= 0.05). For the analysis on the number of patients with a reduction in pain, data were available for 445 patients (224-medication group, 221-placebo group). More patients in the psychotropic drug group experienced a meaningful reduction in pain score at 12–13 weeks of therapy compared to placebo (OR 1.66, 95% CI 1.08–2.54, p= 0.02). Conclusion The results of this meta-analysis demonstrate significant analgesic efficacy of psychotropic medications in the management of children with chronic pain. This review is limited by the small number of studies included for analysis. There is a pressing need for more robust clinical trials to further investigate these promising findings.

show abstract

The central effects of buspirone on abdominal pain in rats

Abstract: Buspirone exerts complex biphasic action on the pain-related VLM neuron activity inversely depending on dose. The final effect of buspirone depends on the functional balance between of activation the pre- and postsynaptic 5-HT Rs in mediating pain control networks.

Cited by 10 publications

References 68 publications

Opposing effects of 5‐HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats

Opposing effects of 5‐HT1A receptor agonist buspirone on supraspinal abdominal pain transmission in normal and visceral hypersensitive rats

Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex

Are Psychotropic Medications Effective in Chronic Pain Management in Children and Adolescents? A Meta-Analysis of Randomized Control Trials

Contact Info

Product

Resources

About