The central autonomic system revisited – Convergent evidence for a regulatory role of the insular and midcingulate cortex from neuroimaging meta-analyses

Ferraro, Stefania; Klugah‐Brown, Benjamin; Tench, Christopher R.; Bazinet, Vincent; Bore, Mercy Chepngetich; Nigri, Anna; Demichelis, Greta; Bruzzone, Maria Grazia; Palermo, Sara; Zhao, Weihua; Yao, Shuxia; Jiang, Xi; Kendrick, Keith M.; Becker, Benjamin

doi:10.1016/j.neubiorev.2022.104915

Cited by 27 publications

(16 citation statements)

References 107 publications

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“…[27][28][29] Although TBSS analysis showed no significant difference between NOH and MOH patients, the ROI analysis revealed that the ODI of the left CgC in the MOH group was reduced to varying degrees when compared with that of NOH and SOH coun- gyrus, thus playing a role in the regulation of cardiovascular function. 30,31 The role of CgC in blood pressure regulation has been documented many times and is well established. 32,33 In the current study, the findings strongly suggest an earlier degenerative limbic system and is usually divided into three parts: the temporal segment, the intermediate/insular segment, and the ventral/frontal extension.…”

Section: Discussionmentioning

confidence: 99%

“…This finding also highlights the importance of considering OH severity in investigating the abnormalities of the WM microstructure in OH patients. As an important part of the central autonomic neural network, CgC connects the frontal, parietal, and medial temporal lobes, as well as the subcortical nucleus and cingulate gyrus, thus playing a role in the regulation of cardiovascular function 30,31 . The role of CgC in blood pressure regulation has been documented many times and is well established 32,33 .…”

Section: Discussionmentioning

confidence: 99%

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Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study

Cheng,

Lin,

Jiang

et al. 2024

CNS Neurosci Ther

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ObjectiveScarce evidence is available to elucidate the association between the abnormal microstructure of white matter (WM) and cognitive performance in patients with orthostatic hypotension (OH). This study investigated the microstructural integrity of WM in patients with mild OH (MOH) and severe OH (SOH) and evaluated the association of abnormal WM microstructure with the broad cognitive domains and cognition‐related plasma biomarkers.MethodsOur study included 72 non‐OH (NOH), 17 MOH, and 11 SOH participants. Across the groups, the WM integrity was analyzed by neurite orientation dispersion and density imaging (NODDI), and differences in WM microstructure were evaluated by nonparametric tests and post hoc models. The correlations between WM microstructure and broad cognitive domains and cognition‐related plasma biomarkers were assessed by Spearman's correlation analysis.ResultsThe abnormal WM microstructure was localized to the WM fiber bundles in MOH patients but distributed widely in SOH cohorts (p < 0.05). Further analysis showed that the neurite density index of the left cingulate gyrus was negatively associated with amyloid β‐40, glial fibrillary acidic protein, neurofilament light chain, phospho‐tau181 (p < 0.05) but positively with global cognitive function (MOCA, MMSE, AER‐III), memory, attention, language, language fluency, visuospatial function and amyloid β‐40 / amyloid β‐42 (p < 0.05). Additionally, other abnormal WM microstructures of OH were associated with broad cognitive domains and cognition‐related plasma biomarkers to varying degrees.ConclusionThe findings evidence that abnormal WM microstructures may present themselves as early as in the MOH phase and that these structural abnormalities are associated with cognitive functions and cognition‐related plasma biomarkers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study

Cheng,

Lin,

Jiang

et al. 2024

CNS Neurosci Ther

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“…A plethora of human studies employed functional Magnetic Resonance Imaging (fMRI) to determine the neural basis of disgust, yet findings with respect to the neural systems that mediate conscious disgust experience remained highly inconsistent. For example, the insula has been traditionally considered as a key neural substrate of disgust 7,8,22,23 , however several studies did not observe insula engagement in response to disgust stimuli [24][25][26][27][28] and recent evidence suggests a broader role of the insula in interoceptive 29,30 , central autonomic 31 , and individual-level emotional information processing 32,33 . Subcortical regions like the amygdala and basal ganglia have also been considered as key disgust regions 8,22,34 , probably due to their roles in early threat detection and defensive motor responses 8,17,18 .…”

Section: Introductionmentioning

confidence: 99%

Rotten to the core – a neurofunctional signature of subjective core disgust generalizes to oral distaste and socio-moral contexts

Gan,

Zhou,

et al. 2023

Preprint

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While disgust originates in the hard-wired mammalian distaste response, the conscious experience of disgust in humans strongly depends on subjective appraisal and may even extend to sociomoral contexts. In a series of studies, we combined functional magnetic resonance imaging (fMRI) with machine-learning based predictive modeling to establish a comprehensive neurobiological model of subjective disgust. The neurofunctional signature accurately predicted momentary self-reported subjective disgust across discovery (n=78) and pre-registered validation (n=30) cohorts and generalized across core disgust (n=26) and sociomoral (unfair offers; n=43) contexts. Disgust experience was encoded in distributed cortical and subcortical systems, and exhibited distinct and shared neural representations with subjective fear or negative affect in interoceptive-emotional awareness and conscious appraisal systems while the signatures most accurately predicted the respective target experience. We provide an accurate fMRI-signature for disgust with a high potential to resolve ongoing evolutionary and clinical debates.

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“…Although it is unclear whether music-induced emotions serve such homeostatic function, interoception and somatosensory feedback may constitute a key pathway also for the elicitation and differentiation of music-induced emotions (Nummenmaa et al, 2021), especially as musicinduced emotions and body movement are closely intertwined (Sievers et al, 2013). Accordingly, brain regions involved in autonomic regulation such as the insula and anterior cingulate cortex (ACC) (Ferraro et al, 2022) have been implicated in music-induced emotions (Koelsch, 2014). Moreover, pattern classification of fMRI data has shown that specific music-induced emotions can be decoded from activity of the somatosensory and motor regions of the brain (Koelsch et al, 2021;Putkinen et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Bodily maps of musical sensations generalize across cultures

Putkinen¹,

Zhou²,

Gan³

et al. 2023

Preprint

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Bodily sensations and movement are integral parts of musical experiences. Yet, it remains unknown i) whether emotional connotations and structural features of music elicit discrete bodily sensations and ii) whether these sensations are culturally consistent. We addressed these questions by presenting Western (European and North American, n = 589) and East Asian (Chinese, n = 517) participants with silhouettes of human bodies and asked them to indicate the bodily regions whose activity they felt changing while listening to Western and Asian musical pieces with varying emotional and acoustic qualities. The resulting bodily sensation maps (BSMs) varied as a function of the affective qualities of the songs, particularly in the limb, chest, and head regions. Music-induced emotions and corresponding BSMs were robustly replicable across both Western and East Asian subjects. The BSMs clustered similarly across cultures, and cluster structures were similar for BSMs and self-reports of emotional experience. The acoustic and structural features of music were consistently associated with the emotion ratings and music-induced bodily sensations across cultures. These results highlight the importance of somatosensation and interoception in music-induced affective experience and suggest culturally universal associations between musical features, music-induced emotions, and bodily sensations.

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The central autonomic system revisited – Convergent evidence for a regulatory role of the insular and midcingulate cortex from neuroimaging meta-analyses

Cited by 27 publications

References 107 publications

Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study

Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study

Rotten to the core – a neurofunctional signature of subjective core disgust generalizes to oral distaste and socio-moral contexts

Bodily maps of musical sensations generalize across cultures

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