The Center for Integrated Molecular Brain Imaging (Cimbi) database

Knudsen, Gitte Moos; Jensen, P.S.; Erritzoe, David; Baaré, William F.C.; Ettrup, Anders; Fisher, Patrick M.; Gillings, Nic; Hansen, Hanne D.; Hansen, Lars Kai; Hasselbalch, Steen G.; Henningsson, Susanne; Herth, Matthias M.; Holst, Klaus K.; Iversen, Pernille; Kessing, Lars Vedel; Macoveanu, Julian; Madsen, Kathrine Skak; Mortensen, Erik Lykke; Nielsen, Finn Årup; Paulson, Olaf B.; Siebner, Hartwig R.; Stenbæk, Dea Siggaard; Svarer, Claus; Jernigan, Terry L.; Strother, Stephen C.; Frøkjær, Vibe G.

doi:10.1016/j.neuroimage.2015.04.025

Cited by 102 publications

(92 citation statements)

References 55 publications

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“…Participants. The participants were healthy male and female controls from the freely available Cimbi database (63). The present data analysis was restricted to include individuals aged between 18 and 45 y.…”

Section: Methodsmentioning

confidence: 99%

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Dynamic coupling of whole-brain neuronal and neurotransmitter systems

Kringelbach

Cruzat

Cabral

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

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215

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Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.

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Section: Methodsmentioning

confidence: 99%

“…PET and structural MRI. Full details on PET and structural MRI acquisition parameters can be found in the original study (63) and in abbreviated form in ref. 9.…”

Section: Methodsmentioning

confidence: 99%

Dynamic coupling of whole-brain neuronal and neurotransmitter systems

Kringelbach

Cruzat

Cabral

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

218

215

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“…26 All participants were recruited by advertisement for different research protocols approved by the Ethics Committee of Copenhagen and Frederiksberg, Denmark ((KF) 01-124/04, (KF) 01-156/04, (KF) 01 2006-20, H-1-2010-085, H-1-2010-91, H-2-2010-108, including amendments). Written informed consent was obtained from all participants after a complete description of the respective study.…”

Section: Methodsmentioning

confidence: 99%

BDNF val66met association with serotonin transporter binding in healthy humans

et al. 2017

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The serotonin transporter (5-HTT) is a key feature of the serotonin system, which is involved in behavior, cognition and personality and implicated in neuropsychiatric illnesses including depression. The brain-derived neurotrophic factor (BDNF) val66met and 5-HTTLPR polymorphisms have predicted differences in 5-HTT levels in humans but with equivocal results, possibly due to limited sample sizes. Within the current study we evaluated these genetic predictors of 5-HTT binding with [11C]DASB positron emission tomography (PET) in a comparatively large cohort of 144 healthy individuals. We used a latent variable model to determine genetic effects on a latent variable (5-HTTLV), reflecting shared correlation across regional 5-HTT binding (amygdala, caudate, hippocampus, midbrain, neocortex, putamen and thalamus). Our data supported a significant BDNF val66met effect on 5-HTTLV such that met-carriers showed 2–7% higher subcortical 5-HTT binding compared with val/val individuals (P=0.042). Our data did not support a BDNF val66met effect in neocortex and 5-HTTLPR did not significantly predict 5-HTTLV. We did not observe evidence for an interaction between genotypes. Our findings indicate that met-carriers have increased subcortical 5-HTT binding. The small difference suggests limited statistical power may explain previously reported null effects. Our finding adds to emerging evidence that BDNF val66met contributes to differences in the human brain serotonin system, informing how variability in the 5-HTT level emerges and may represent an important molecular mediator of BDNF val66met effects on behavior and related risk for neuropsychiatric illness.

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“…Data were extracted from the Center for Integrated Molecular Brain Imaging (Cimbi) database for healthy individuals with either a [ 18 F]altanserin or [ 11 C]Cimbi‐36 PET scan and NEO Personality Inventory‐Revised (NEO PI‐R) data (Knudsen et al, ). Of the initial 200 healthy individuals identified, we excluded individuals with more than 365 days between their PET scan and NEO PI‐R assessment ( n = 5), and who had a body mass index of >30, corresponding to obese ( n = 36), in reference to an earlier study of personality differences between obese and nonobese individuals in our database (Haahr et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…However, some [ 18 F]altanserin data sets were acquired before this information was systematically collected and is not known ( n = 33). A detailed description of the Cimbi database and the PET biomarkers that it contains can be found elsewhere (Beliveau & Ganz, ; Knudsen et al, ).…”

Section: Methodsmentioning

confidence: 99%

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

Stenbæk

Kristiansen

Madsen

et al. 2019

Human Brain Mapping

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Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5‐HT2AR) agonist psilocybin. However, no studies have investigated whether 5‐HT2AR availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the association between 5‐HT2AR binding in neocortex imaged with [18F]altanserin or [11C]Cimbi‐36 PET and personality trait Openness was investigated using linear regression models. In these models the influence of sex on the association was also investigated. Trait Openness was assessed with the NEO Personality Inventory‐Revised. No significant associations between neocortical 5‐HT2AR binding and trait Openness were found for [18F]altanserin (p = 0.5) or [11C]Cimbi‐36 (p = 0.8). Pooling the data in a combined model did not substantially change our results (p = 0.4). No significant interactions with sex were found (p > 0.35). Our results indicate that differences in 5‐HT2AR availability are not related to variations in trait Openness in healthy individuals. Although stimulation of the 5‐HT2AR with compounds such as psilocybin may contribute to long‐term changes in trait Openness, there is no evidence in favor of an association between 5‐HT2AR and trait Openness.

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The Center for Integrated Molecular Brain Imaging (Cimbi) database

Cited by 102 publications

References 55 publications

Dynamic coupling of whole-brain neuronal and neurotransmitter systems

Dynamic coupling of whole-brain neuronal and neurotransmitter systems

BDNF val66met association with serotonin transporter binding in healthy humans

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study

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