The cellular language of<i>myo‐</i>inositol signaling

Gillaspy, Glenda E.

doi:10.1111/j.1469-8137.2011.03939.x

Cited by 136 publications

(115 citation statements)

References 207 publications

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“…However, PLC genes, which catalyze the crucial IP3-enerating step in PI signaling (Gillaspy, 2011), showed decreases in transcript abundance in both tissues, suggesting that differences in PI signaling may not form part of the mechanism(s) that underlies the relative sensitivity of early maize embryos to drought stress.…”

Section: Invertase In Its Metabolic and Likely Signaling Rolementioning

confidence: 98%

Effects of Drought on Gene Expression in Maize Reproductive and Leaf Meristem Tissue Revealed by RNA-Seq

et al. 2012

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Drought stress affects cereals especially during the reproductive stage. The maize (Zea mays) drought transcriptome was studied using RNA-Seq analysis to compare drought-treated and well-watered fertilized ovary and basal leaf meristem tissue. More drought-responsive genes responded in the ovary compared with the leaf meristem. Gene Ontology enrichment analysis revealed a massive decrease in transcript abundance of cell division and cell cycle genes in the drought-stressed ovary only. Among Gene Ontology categories related to carbohydrate metabolism, changes in starch and Suc metabolism-related genes occurred in the ovary, consistent with a decrease in starch levels, and in Suc transporter function, with no comparable changes occurring in the leaf meristem. Abscisic acid (ABA)-related processes responded positively, but only in the ovaries. Related responses suggested the operation of low glucose sensing in drought-stressed ovaries. The data are discussed in the context of the susceptibility of maize kernel to drought stress leading to embryo abortion and the relative robustness of dividing vegetative tissue taken at the same time from the same plant subjected to the same conditions. Our working hypothesis involves signaling events associated with increased ABA levels, decreased glucose levels, disruption of ABA/sugar signaling, activation of programmed cell death/senescence through repression of a phospholipase C-mediated signaling pathway, and arrest of the cell cycle in the stressed ovary at 1 d after pollination. Increased invertase levels in the stressed leaf meristem, on the other hand, resulted in that tissue maintaining hexose levels at an "unstressed" level, and at lower ABA levels, which was correlated with successful resistance to drought stress.

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Section: Invertase In Its Metabolic and Likely Signaling Rolementioning

confidence: 98%

Effects of Drought on Gene Expression in Maize Reproductive and Leaf Meristem Tissue Revealed by RNA-Seq

et al. 2012

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“…Both types of CRC are closely related and share some characteristic features (Taylor et al, 2004;Taylor et al, 2009;Boehning, 2010;Seo et al, 2012). However, CRCs have not been identified in many unicellular organisms or in plants (Gillaspy, 2011). Considering that choanoflagellates are at the roots of metazoans, it is of interest that database mining suggests for Monosiga brevicollis the absence of RyRs but the presence of InsP 3 Rs (Cai, 2008).…”

Section: +mentioning

confidence: 99%

Ca2+ signalling early in evolution – all but primitive

Plattner

Verkhratsky

2013

Journal of Cell Science

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SummaryEarly in evolution, Ca 2+ emerged as the most important second messenger for regulating widely different cellular functions. In eukaryotic cells Ca 2+ signals originate from several sources, i.e. influx from the outside medium, release from internal stores or from both. In mammalian cells, Ca 2+ -release channels represented by inositol 1,4,5-trisphosphate receptors and ryanodine receptors (InsP 3 R and RyR, respectively) are the most important. In unicellular organisms and plants, these channels are characterised with much less precision. In the ciliated protozoan, Paramecium tetraurelia, 34 molecularly distinct Ca 2+ -release channels that can be grouped in six subfamilies, based on criteria such as domain structure, pore, selectivity filter and activation mechanism have been identified. Some of these channels are genuine InsP 3 Rs and some are related to RyRs. Others show some -but not all -features that are characteristic for one or the other type of release channel. Localisation and gene silencing experiments revealed widely different -yet distinctlocalisation, activation and functional engagement of the different Ca 2+ -release channels. Here, we shall discuss early evolutionary routes of Ca 2+ -release machinery in protozoa and demonstrate that detailed domain analyses and scrutinised functional analyses are instrumental for in-depth evolutionary mapping of Ca 2+ -release channels in unicellular organisms.

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“…It negatively controls the autoimmune response and it contributes to proper root development. These broad roles could be due to the role of MI as a precursor of phosphatidylinositol (PtdIns), which is an essential cellular compound involved in various biochemical and physiological processes, including intracellular signal transduction (Gillaspy, 2011), membrane construction and trafficking (Cullen, 2011), and membrane-related protein anchoring (Borner et al, 2005). Indeed, the loss of MIPS1 leads to drastically reduced PtdIns levels and affects endomembrane structure and trafficking and, consequently, pattern formation by regulating auxin distribution (Chen and Xiong, 2010;Zhang et al, 2010;Luo et al, 2011).…”

Section: Cpsf30 Is a Positive Regulator Of The Defense Responses Thatmentioning

confidence: 99%

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

et al. 2014

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Programmed cell death (PCD) is essential for several aspects of plant life, including development and stress responses. Indeed, incompatible plant-pathogen interactions are well known to induce the hypersensitive response, a localized cell death. Mutational analyses have identified several key PCD components, and we recently identified the mips1 mutant of Arabidopsis (Arabidopsis thaliana), which is deficient for the key enzyme catalyzing the limiting step of myoinositol synthesis. One of the most striking features of mips1 is the light-dependent formation of lesions on leaves due to salicylic acid (SA)-dependent PCD, revealing roles for myoinositol or inositol derivatives in the regulation of PCD. Here, we identified a regulator of plant PCD by screening for mutants that display transcriptomic profiles opposing that of the mips1 mutant. Our screen identified the oxt6 mutant, which has been described previously as being tolerant to oxidative stress. In the oxt6 mutant, a transfer DNA is inserted in the CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog. We show that CPSF30 is required for lesion formation in mips1 via SA-dependent signaling, that the prodeath function of CPSF30 is not mediated by changes in the glutathione status, and that CPSF30 activity is required for Pseudomonas syringae resistance. We also show that the oxt6 mutation suppresses cell death in other lesion-mimic mutants, including lesion-simulating disease1, mitogen-activated protein kinase4, constitutive expressor of pathogenesis-related genes5, and catalase2, suggesting that CPSF30 and, thus, the control of messenger RNA 39 end processing, through the regulation of SA production, is a key component of plant immune responses.

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The cellular language ofmyo‐inositol signaling

Cited by 136 publications

References 207 publications

Effects of Drought on Gene Expression in Maize Reproductive and Leaf Meristem Tissue Revealed by RNA-Seq

Effects of Drought on Gene Expression in Maize Reproductive and Leaf Meristem Tissue Revealed by RNA-Seq

Ca2+ signalling early in evolution – all but primitive

The Polyadenylation Factor Subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A Key Factor of Programmed Cell Death and a Regulator of Immunity in Arabidopsis

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