The cellular immunity and oxidative stress markers in early pregnancy loss

Dağlar, Korkut; Biberoğlu, Ebru; Kırbaş, Ayşe; Dirican, Aylin Onder; Genç, Metin; Avcı, Aslıhan; Biberoğlu, Kutay

doi:10.3109/14767058.2015.1064886

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…A recent study has demonstrated a link between compensated oxidative stress and spontaneous abortion in women with early spontaneous pregnancy loss compared to normal women with ongoing pregnancy. 15…”

Section: Discussionmentioning

confidence: 99%

Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Elbadry¹,

Rezk²,

Elsayed³

2018

Int J Occup Environ Med

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Background: Dental staff may be at increased risk of adverse pregnancy outcome secondary to their chronic exposure to mercury.Objective: To investigate obstetric outcome among dental staff and explore the oxidative stress induced by mercury exposure.Methods: A cohort of 64 pregnant dental staff (exposed group) and 60 pregnant employees (non-exposed group) were studied. Urinary mercury level and blood antioxidant activity were measured. Participants were followed to assess their obstetric outcome.Results: The exposed group had a higher mean urinary mercury level and a lower blood antioxidant activity during the three trimesters compared to non-exposed group (p<0.001). Women in the exposed group were experienced more frequently spontaneous abortion and pre-eclampsia (p<0.05). Babies born to the women in the exposed group tended to be smaller for gestational age compared to those of non-exposed group (p<0.001).Conclusion: Pregnant dental staff suffered higher odds of developing spontaneous abortion and pre-eclampsia and giving birth to babies smaller for gestational age. This may be linked to oxidative stress induced by exposure to mercury.

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Section: Discussionmentioning

confidence: 99%

Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Elbadry¹,

Rezk²,

Elsayed³

2018

Int J Occup Environ Med

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“…BPA toxicity on female reproduction also involves the occurrence of endometriosis, miscarriage, and abnormalities of uterus morphology [94]. The common thread among these disorders is the increased oxidative stress [126], along with the activation of inflammatory signaling. Indeed, Cho et al [22] have demonstrated the capability of BPA to induce oxidative stress and inflammatory mediators in human endometrial cells.…”

Section: Oxidative Stress-induced Bpa Toxicity On Male and Female Rep...mentioning

confidence: 99%

Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction

et al. 2020

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Bisphenol A (BPA) is a non-persistent anthropic and environmentally ubiquitous compound widely employed and detected in many consumer products and food items; thus, human exposure is prolonged. Over the last ten years, many studies have examined the underlying molecular mechanisms of BPA toxicity and revealed links among BPA-induced oxidative stress, male and female reproductive defects, and human disease. Because of its hormone-like feature, BPA shows tissue effects on specific hormone receptors in target cells, triggering noxious cellular responses associated with oxidative stress and inflammation. As a metabolic and endocrine disruptor, BPA impairs redox homeostasis via the increase of oxidative mediators and the reduction of antioxidant enzymes, causing mitochondrial dysfunction, alteration in cell signaling pathways, and induction of apoptosis. This review aims to examine the scenery of the current BPA literature on understanding how the induction of oxidative stress can be considered the “fil rouge” of BPA’s toxic mechanisms of action with pleiotropic outcomes on reproduction. Here, we focus on the protective effects of five classes of antioxidants—vitamins and co-factors, natural products (herbals and phytochemicals), melatonin, selenium, and methyl donors (used alone or in combination)—that have been found useful to counteract BPA toxicity in male and female reproductive functions.

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“…Over the years, infertility related to OS has become an area of great concern for clinicians and scientists because continuous formation of ROS throughout the life of an organism leads to cumulative damage, which impairs fertility via programmed deterioration. The deleterious consequences of OS include impairment of semen parameters (Agarwal et al, 2005;Bansal and Bilaspuri, 2010;Pasqualotto et al, 2000), poor fertilization, poor embryonic development (Jana et al, 2010;Oyawoye et al, 2003) and pregnancy loss (Cengiz et al, 2016;Daglar et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Potential role of green tea catechins in the management of oxidative stress-associated infertility

Roychoudhury

Agarwal

Virk

et al. 2017

Reproductive BioMedicine Online

117

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The cellular immunity and oxidative stress markers in early pregnancy loss

Abstract: We have demonstrated an increased cellular immunity and perhaps a compensated oxidative stress related to increased antioxidant activation in women with early spontaneous pregnancy loss.

Cited by 8 publications

References 29 publications

Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Mercury-induced Oxidative Stress May Adversely Affect Pregnancy Outcome among Dental Staff: A Cohort Study

Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction

Potential role of green tea catechins in the management of oxidative stress-associated infertility

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