The Cellular Composition of the Human Oviduct Epithelium

Critoph, Frances N.; Dennis, K. J.

doi:10.1111/j.1471-0528.1977.tb12559.x

Cited by 26 publications

(8 citation statements)

References 2 publications

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“…In primates, the TEC of the distal fimbriae of the fallopian tube are comparable to the TEC of the mouse oviduct (Critoph and Dennis 1977; Komatsu and Fujita 1978). However, TEC are found on the outer surface of the fimbriae and are in contact with the ovary and face the peritoneal cavity, rather than facing the lumen of the oviduct as in mice.…”

Section: Resultsmentioning

confidence: 86%

The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer

King¹,

Hilliard²,

Wu³

et al. 2011

Endocrine-Related Cancer

119

118

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Ovarian cancer is the most lethal gynecological malignancy affecting American women. Current hypotheses concerning the etiology of ovarian cancer propose that a reduction in the lifetime number of ovulations decreases ovarian cancer risk. Advanced serous carcinoma shares several biomarkers with fallopian tube epithelial cells, suggesting that some forms of ovarian carcinoma may originate in the fallopian tube. Currently, the impact of ovulation on the tubal epithelium is unknown. In CD1 mice, ovulation did not increase tubal epithelial cell proliferation as measured by bromodeoxyuridine incorporation and proliferating cell nuclear antigen staining as compared to unstimulated animals. In superovulated mice, an increase in the number of pro-inflammatory macrophages was detected in the oviduct. Ovulation also increased levels of phospho-γH2A.X in tubal epithelial cells, indicating that these cells were susceptible to double-strand DNA breakage following ovulation. To determine which components of ovulation contributed to DNA damage in the fallopian tube, an immortalized baboon tubal epithelial cell line and a three-dimensional organ culture system for mouse oviduct and baboon fallopian tubes were developed. Tubal epithelial cells did not proliferate or display increased DNA damage in response to the gonadotropins or estradiol alone in vitro. Oxidative stress generated by treatment with hydrogen peroxide or macrophage-conditioned medium increased DNA damage in tubal epithelial cells in culture. Ovulation may impact the fallopian tube epithelium by generating DNA damage and stimulating macrophage infiltration, but does not increase proliferation through gonadotropin signaling.

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Section: Resultsmentioning

confidence: 86%

The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer

King¹,

Hilliard²,

Wu³

et al. 2011

Endocrine-Related Cancer

119

118

View full text Add to dashboard Cite

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“…The mucosa is comprised of a single layer of cuboidal cells with two major cell types – ciliated and nonciliated – with branching and folding that is most pronounced in the infundibulum and ampulla (Crow et al , 1994). It is a dynamic tissue whose cellular components respond throughout the menstrual cycle to changes in circulating oestrogen and progesterone (Critoph, Dennis, 1977; Novak and Everett, 1928). Both ciliated and non-ciliated cells gain height as the follicular phase proceeds, and shortly after ovulation, the secretory cells begin secreting their contents into the tubal lumen, leaving prominent-appearing ciliated cells.…”

Section: Discussionmentioning

confidence: 99%

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

Hess

Talbi

Hamilton

et al. 2013

Reproductive BioMedicine Online

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The human oviduct serves as a conduit for spermatozoa in the periovulatory phase and nurtures and facilitates transport of the developing embryo for nidation during the luteal phase. Interactions between the embryo and oviductal epithelial surface proteins and secreted products during embryo transit are largely undefined. This study investigated gene expression in the human oviduct in the early luteal versus follicular phases to identify candidate genes and biomolecular processes that may participate in maturation and transport of the embryo as it traverses this tissue. Oviductal RNA was hybridized to oligonucleotide arrays and resulting data were analysed by bioinformatic approaches. There were 650 genes significantly down-regulated and 683 genes significantly up-regulated (P < 0.05) in the luteal versus follicular phase. Quantitative real-time PCR, immunoblot analysis and immunohistochemistry confirmed selected gene expression and cellular protein localization. Down-regulated genes involved macrophage recruitment, immunomodulation and matrix-degeneration, and up-regulated genes involved anti-inflammatory, ion transport, anti-angiogenic and early pregnancy recognition. The oviduct displayed some similarities and differences in progesterone-regulated genes compared with the human endometrium. Together, these data suggest a unique hormonally regulated environment during embryo development, maturation and transport through human oviduct and some conservation of progesterone signalling in tissues of common embryological origin.

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“…However, it is likely that ovulation impacts the fallopian tube as well as the OSE, and the non-human primate is better poised to analyze the influx of hormones and inflammatory factors acting on this tissue as the hen oviduct is significantly anatomically different from that of the human. Alternatively, laboratory rodents exhibit anatomy more similar to the human and non-human primate, with the rodent oviduct comparable to the human fallopian tube (54,55). Importantly, rodents demonstrate similar ovulatory cycles to the human; the existence of a luteal phase, although shorter than that of the human, allows for examination of progesterone signaling (56).…”

Section: Animal Models That Develop Spontaneous Ovarian Carcinomamentioning

confidence: 99%

The Cellular Composition of the Human Oviduct Epithelium

Cited by 26 publications

References 2 publications

The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer

The impact of ovulation on fallopian tube epithelial cells: evaluating three hypotheses connecting ovulation and serous ovarian cancer

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

Evaluating the progenitor cells of ovarian cancer: analysis of current animal models

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