The cellular composition and morphological organization of the rostral migratory stream in the adult human brain

Kam, Monica; Curtis, Maurice A.; McGlashan, Susan R.; Connor, Bronwen; Nannmark, Ulf; Faull, Richard L.M.

doi:10.1016/j.jchemneu.2008.12.009

Cited by 85 publications

(85 citation statements)

References 36 publications

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“…The general configuration of the RMS in the adult human brain parenchyma demonstrated by DAPI staining in the present study is consistent with these studies [21,22]. However, it is worth noting that the large number of PCNA+ cells in the RMS shown in these studies [21,22] does not necessarily mean that they are proliferating cells. Indeed, we and others only found a very small number of MCM2+ and Ki67+ cells in the SVZ and RMS of the adult human brain (Figures 7 and 8) [14,20,23].…”

Section: Discussionsupporting

confidence: 90%

“…Curtis et al previously established a similar RMSlike pathway from the adult human SVZ to the OB using PCNA, PSA-NCAM and Tuj1 immunostaining [21]. The general configuration of the RMS in the adult human brain parenchyma demonstrated by DAPI staining in the present study is consistent with these studies [21,22]. However, it is worth noting that the large number of PCNA+ cells in the RMS shown in these studies [21,22] does not necessarily mean that they are proliferating cells.…”

Section: Discussionsupporting

confidence: 87%

“…This observation is further supported by GFAP immunostaining in 50-µm coronal sections, as GFAP+ cells and their processes forming the glial tubes surround the RMS (Figures 3B', 3D', 3H', 4 and Supplementary information, Figure S4D-S4F). The configuration of the RMS in the adult human brain parenchyma demonstrated by DAPI staining in the present study was consistent with previous studies, in which the RMS was identified fortuitously using proliferating cell nuclear antigen (PCNA) immunostaining [21,22].…”

Section: The Rms Exists In the Adult Human Brainsupporting

confidence: 92%

“…In the adult rodent and monkey brain, newly born neuroblasts in the SVZ migrate through the RMS to the OB [6,7,[9][10][11][12][13]. However, whether there is an RMSlike pathway in the adult human brain remains highly controversial [14,[20][21][22]. In the present study, we first showed the configuration of the RMS in the adult rhesus monkey brain.…”

Section: Discussionmentioning

confidence: 63%

“…Two studies have also indicated the presence of a putative RMS in the fetal human brain [18,19]. However, evidence for the presence of SVZ neurogenesis and an RMS-like pathway in the adult human brain remains highly controversial [14,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain

et al. 2011

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It is of great interest to identify new neurons in the adult human brain, but the persistence of neurogenesis in the subventricular zone (SVZ) and the existence of the rostral migratory stream (RMS)-like pathway in the adult human forebrain remain highly controversial. In the present study, we have described the general configuration of the RMS in adult monkey, fetal human and adult human brains. We provide evidence that neuroblasts exist continuously in the anterior ventral SVZ and RMS of the adult human brain. The neuroblasts appear singly or in pairs without forming chains; they exhibit migratory morphologies and co-express the immature neuronal markers doublecortin, polysialylated neural cell adhesion molecule and βIII-tubulin. Few of these neuroblasts appear to be actively proliferating in the anterior ventral SVZ but none in the RMS, indicating that neuroblasts distributed along the RMS are most likely derived from the ventral SVZ. Interestingly, no neuroblasts are found in the adult human olfactory bulb. Taken together, our data suggest that the SVZ maintains the ability to produce neuroblasts in the adult human brain.

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