The Cellular and Molecular Mechanism of Radiation-Induced Lung Injury

Huang, Yijuan; Zhang, Weiqiang; Yu, Fang; Fu, Guosheng

doi:10.12659/msm.902353

Cited by 77 publications

(48 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At an earlier stage, there was a hot discussion on the relationship between TCM syndromes and immune cytokines, which induced the connection of Yin and immunity [7]. According to a study at present, the mechanism of RP relates to both immune imbalance and deficiency of Yin [8]. As shown in Figure 1, the disorder of proinflammatory factor and anti-inflammatory factor in the development of RP will lead to imbalance in cellular immunity, especially in the homeostasis of Th1/Th2.…”

Section: Introductionmentioning

confidence: 99%

Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

Yang

Zhou

2019

BioMed Research International

View full text Add to dashboard Cite

Objective. Studying correlative changes of Th1/Th2 (Th, Helper T cells) related factor Interferon-γ (IFN-γ) and Interleukin-4 (IL-4) in the progression of radiation pneumonia (RP) rats and the efficacy of Shashen-Maidong decoction on these indexes to explore the immune mechanism of the decoction on the prevention and treatment of RP. Methods. Male 60 Sprague-Dawley (SD) rats were randomly divided into four groups. In addition to the normal control group taking saline, the other rats were set up RP model treated with Shashen-Maidong decoction or dexamethasone (DXM), respectively. The IFN-γ and IL-4 concentrations in serum and bronchoalveolar lavage fluid (BALF) of rats were tested in the 2nd and 4th week after radiation, and the relative ratio of IFN-γ/IL-4 was calculated. Results. (1) There was significant difference of serum IL-4 concentrations in group B (p<0.01) and extreme difference in groups C and D (p<0.001) compared with group A in 4th week. Compared with group D, IL-4 concentrations in group B increased significantly in both 2nd and 4th week (p<0.01). Group B had significantly decreased IFN-γ concentrations in BALF (p<0.001) compared with group D in the 4th week. And IFN-γ concentrations in BALF in group B were increased compared with group C in the 4th week (p<0.05). (2) There was no difference of the relative ratio of IFN-γ/IL-4 at each time in groups B and A for both serum and BALF, while the ratios in groups C and D in 4th week in BALF were increased (p<0.05) compared to group A. Conclusion. Shashen-Maidong decoction can improve the immune function of RP rats by increasing IFN-γ concentration and decreasing IL-4 concentration, possibly by increasing the relative ratio of IFN-γ/IL-4 to regulate the immune imbalance of Th1/Th2.

show abstract

Section: Introductionmentioning

confidence: 99%

Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

Yang

Zhou

2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Our finding of an association between NF-κB activation and late radiation-induced fibrosis added to current knowledge of associations between molecular radiosensitivity and late tissue toxicity. Late fibrosis is featured by a large deposition of extracellular matrix molecules (e.g., collagens, glycosaminoglycans, and proteoglycans) and an excessive of fibroblast proliferation [33,34]. The survival fraction of cultured fibroblast at 2 Gy was reported to be associated with late fibrosis in the same patients [35,36].…”

Section: Discussionmentioning

confidence: 99%

Association between NF-κB Activation in Peripheral Blood Mononuclear Cells and Late Skin and Subcutaneous Fibrosis following Radiotherapy

Zhang

Sun

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Background. This study aimed at evaluating the association between the speed of nuclear factor-kappa B (NF-κB) activation in peripheral blood mononuclear cells (PBMCs) and late skin and subcutaneous fibrosis in patients with head and neck squamous cell carcinoma (HNSCC) after radiotherapy. Methods. The speed of NF-κB activation was represented by the nuclear p65 expression ratio before and after irradiation. The optimal time point to measure the ratio was determined by Western blot in the PBMCs from healthy outpatients ranging from 0 to 12 hours after ex vivo irradiation. We recruited patients with HNSCC who had received ratiotherapy and who were under regular follow-up care. We assessed the association between the risk of developing ≥grade 2 late fibrosis and the nuclear p65 expression ratio in the PBMCs after ex vivo irradiation in these patients. Results. The maximum nuclear p65 ratio was observed at 1 hour after ex vivo irradiation in the PBMCs from the healthy outpatients. The speed of NF-κB activation was then represented by the nuclear p65 ratio in the PBMCs before and 1 hour after ex vivo irradiation. A total of 200 patients with HNSCC were recruited, 32.50% (n=65) of which presented with ≥grade 2 late fibrosis. There was a significant association between the speed of NF-κB activation in the PBMCs and an increased risk of developing ≥grade 2 late fibrosis in these patients (P=0.004). Subgroup analysis suggested that this finding was independent of the known clinical characteristics. Conclusions. The speed of NF-κB activation might be a potential predictor of late toxicity in cancer patients after radiotherapy. Prospective studies are needed for validation.

show abstract

“…Radiation-induced lung injury (RILI) is a complex process of subacute and chronic cellular and molecular mechanisms, involving damage to alveolar epithelial cells and vascular endothelial cells, activation of macrophages, fibroblast accumulation, proliferation and differentiation, which can lead to radiation-induced pulmonary fibrosis, typically 6e12 months following completion of radiotherapy. 48,49 Most important RILI symptoms are nonproductive cough, exerciseinduced dyspnea, low-grade fever, and chest pain. Nevertheless, some 45% of lung cancer patients treated with radiotherapy may develop cough and dyspnea not related to the radiotherapy, alternatively caused by pulmonary infections, COPD exacerbations, heart failure, cardiac arrhythmias, anemia, and immunotherapy-induced lung tissue changes.…”

Section: Treatment Of Cough and Dyspneamentioning

confidence: 99%

Recommendation for supportive care in patients receiving concurrent chemotherapy and radiotherapy for lung cancer

et al. 2020

View full text Add to dashboard Cite

Concurrent chemotherapy and radiotherapy (CCRT) followed by durvalumab immune therapy in appropriate patients is considered to be the standard of care in most fit stage III non-small-cell lung cancer (NSCLC) patients. However, CCRT is a toxic treatment that affects all organ systems and may cause acute and permanent side effects, some of which may be lethal. Supportive care is therefore of utmost importance in this clinical setting. A group of experts from the European Society for Therapeutic Radiology and Oncology (ESTRO) and the European Society of Medical Oncology (ESMO) identified the following items of importance for further improvement of supportive care: smoking cessation; nutrition before and during CCRT (including treatment and prevention of anorexia); physical exercise before and during CCRT; prevention and treatment of acute esophagitis and dysphagia; treatment of cough and dyspnea; treatment of skin reactions; treatment of fatigue; prophylaxis of nausea and emesis; prevention, diagnosis, and treatment of cardiac disease and damage; and optimization of radiotherapy techniques and chemotherapy adjustments to reduce toxicity in the era of immune therapy. The resulting recommendations are summarized in this manuscript and knowledge gaps identified, in which future investments are needed to improve supportive care and hence quality of life and survival for our stage III NSCLC patients.

show abstract

The Cellular and Molecular Mechanism of Radiation-Induced Lung Injury

Cited by 77 publications

References 41 publications

Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in RP Rats

Association between NF-κB Activation in Peripheral Blood Mononuclear Cells and Late Skin and Subcutaneous Fibrosis following Radiotherapy

Recommendation for supportive care in patients receiving concurrent chemotherapy and radiotherapy for lung cancer

Contact Info

Product

Resources

About