The Cell-Vessel Architecture Model for the Central Respiratory Chemoreceptor

Okada, Yasumasa; Kuwana, Shun-ichi; Oyamada, Yoshitaka; Chen, Zibin

doi:10.1007/0-387-31311-7_36

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Primary chemoreceptor surface cells, which monitor perivascular pH levels, are sited below the major surface vessels inside the glial layer of the medullary surface, as well as surrounding areas of small branches from large surface vessels [23, 24]. Serotonergic neurons in the medulla follow the basilar artery and its branches in close proximity [5].…”

Section: Discussionmentioning

confidence: 99%

“…Serotonergic neurons do not express Phox2b in mice, and are relatively unaffected by Phox2b mutations [8], suggesting that a secondary process elicits the raphé injury, possibly from ischemia resulting from loss of differentiation of autonomic neurons in the condition. Phox2b is found in glutamatergic neurons, however [8], and such neurons also accompany large vessels in the medulla [23, 24], possibly contributing to the dilation here.…”

Section: Discussionmentioning

confidence: 99%

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Dilated basilar arteries in patients with congenital central hypoventilation syndrome

Kumar

Nguyen

Macey

et al. 2009

Neuroscience Letters

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Congenital central hypoventilation syndrome (CCHS) patients show hypoventilation during sleep and severe autonomic impairments, including aberrant cardiovascular regulation. Abnormal sympathetic patterns, together with increased and variable CO 2 levels, lead to the potential for sustained cerebral vasculature changes. We performed high-resolution T1-weighted imaging in 13 CCHS and 31 control subjects using a 3.0-Tesla magnetic resonance imaging scanner, and evaluated resting basilar and bilateral middle cerebral artery cross-sections. Two T1-weighted image series were acquired; images were averaged and reoriented to common space, and regions containing basilar and both middle cerebral arteries were oversampled. Cross-sections of the basilar and middle cerebral arteries were manually outlined to calculate cross-sectional areas, and differences between and within groups were evaluated. Basilar arteries in CCHS were significantly dilated over control subjects, but both middle cerebral artery cross-sections were similar between groups. No significant differences appeared between left and right middle cerebral arteries within either group. Basilar artery dilation may result from differential sensitivity to high CO 2 over other vascular beds, damage to serotonergic or other chemosensitive cells accompanying the artery, or enhanced microvascular resistance, and that dilation may impair tissue perfusion, leading to further neural injury in CCHS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dilated basilar arteries in patients with congenital central hypoventilation syndrome

Kumar

Nguyen

Macey

et al. 2009

Neuroscience Letters

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The Arterial Chemoreceptors

Hayashida¹,

González²,

Kondo³

2006

Advances in Experimental Medicine and Biology

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