The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis
Xin Zhang,
Jiajia Wang,
Kun Tang
et al.
Abstract:The therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction of CD8+ T cells. Continuous antigen stimulation disrupts the expansion, effector function, and metabolic fitness of CD8+ T cells, leading to their differentiation into an exhausted state within the tumor microenvironment (TME). While the function of the cell cycle negative regulator p16 in senescent cells is well understood, its role in T cell exhaustion remains unclear. In this study, we demonstrated… Show more
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