The cell cycle of<i>Escherichia coli</i>and some of its regulatory systems

Képès, François

doi:10.1111/j.1574-6968.1986.tb01195.x

Cited by 20 publications

(2 citation statements)

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“…Again we will review the results in detail in section 2.2. Subsequently, shift-up or shift-down experiments were done by other groups to study bacterial growth [31,32], cell cycle [33][34][35][36], cell division [37], DNA synthesis [38], RNA [39][40][41][42][43][44] and protein sysnthesis [45,46], gene regulation [47][48][49], metabolism [50], morphogenesis [51][52][53] and many other aspects of microbiology [54]. (1900-present).…”

Section: Part I: Key Technology Development and Experimentsmentioning

confidence: 99%

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Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

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Bacterial physiology is a branch of biology that aims to understand overarching principles of cellular reproduction. Many important issues in bacterial physiology are inherently quantitative, and major contributors to the field have often brought together tools and ways of thinking from multiple disciplines. This article presents a comprehensive overview of major ideas and approaches developed since the early 20th century for anyone who is interested in the fundamental problems in bacterial physiology. This article is divided into two parts. In the first part (sections 1-3), we review the first 'golden era' of bacterial physiology from the 1940s to early 1970s and provide a complete list of major references from that period. In the second part (sections 4-7), we explain how the pioneering work from the first golden era has influenced various rediscoveries of general quantitative principles and significant further development in modern bacterial physiology. Specifically, section 4 presents the history and current progress of the 'adder' principle of cell size homeostasis. Section 5 discusses the implications of coarse-graining the cellular protein composition, and how the coarse-grained proteome 'sectors' re-balance under different growth conditions. Section 6 focuses on physiological invariants, and explains how they are the key to understanding the coordination between growth and the cell cycle underlying cell size control in steady-state growth. Section 7 overviews how the temporal organization of all the internal processes enables balanced growth. In the final section 8, we conclude by discussing the remaining challenges for the future in the field.

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Section: Part I: Key Technology Development and Experimentsmentioning

confidence: 99%

“…Tyson and Diekmann [575,576] revived the formalism by Collins and Richmond almost three decades later. They rewrote equation (35) in a differential form as…”

Section: Non-equilibrium Statistical Mechanics Formalism For Size Con...mentioning

confidence: 99%

Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

et al. 2018

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Stepwise increase of elongation rate in individual hyphae of Streptomyces granaticolor during outgrowth

Kretschmer¹

1988

J. Basic Microbiol.

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Starting with germinating spores of Streptornyces granaticolor, the kinetics of elongation of 3 types of outgrowing hyphae was determined. The 3 hyphal types were: first germ tube, second germ tube (which appeared from the same spores about 3 hours later) and branches arising from the first germ tubes. Taking photographs every fifth minute, with all hyphae a linear multiphasic elongation behaviour was found. Alternatively, periods with constant elongation rate (a) changed with steps at which a increased abruptly. Several successive shifts were observed until finally at a hyphal length of about 25 pm a constant maximum a of about 22 pm h -' was attained.The length of the periods during which a remained constant did not depend on either the hyphal type or the order of the period. On an average, a single period lasted 46.8 minutes.The lengths of the hyphae, at the time when a increased, corresponded for the first germ tubes to successively about 2.4.8 and 16 unit cells. With branchesand second germ tubes these lengthscorresponded to4and 10 unit cells.Concerning increase of a during each step the quotients were in the range between 1.3 and 2.0. Branches and second germ tubes started with twice the rate observed with first germ tubes and thus reached the maximum a after a reduced number of steps. Calculations indicated, that on principle a of each linear period was determined by the number of unit cells (nucleoids) present at its beginning.Earlier studies on the growth kinetics of Streptomycetes delt mainly with the development of whole mycelia. It was found that the total length of mycelial hyphae increased exponentially due to the exponential increase of the number of branches. The similarity of both kinetics led to the conclusion that the individual hyphae elongated with a constant elongation rate (a), i.e., hyphal growth was linear (SCHUHMANN and BERGTER 1976, KRETSCHMER 1982, ALLAN andPROSSER 1983). However, concerning the initial phase of outgrowth of hyphae (either from spores or from main hyphae during branching) before branching, contradictory results have been published. In Streptomyces hygroscopicus on rich as well as on minimal medium germ tubes elongated exponentially (but the doubling time decreased before branching started), while branches elongated rather linearly (SCHUHMANN and BERGTER 1976). In Streplomyces coelicoior on minimal medium both germ tubes as well as branch hyphae initially showed linear elongation, which increased in rate lateron (ALLAN and PROSSER 1983).For s. granaticolor germ tubes an exponential growth behaviour was found on rich medium (KRETSCHMER 1982).These controversies, indicating a rather complex growth behaviour of young hyphae, may be resolved by using a more detailed (nearly-kinematographic) mode of observation. The yet unbranched stage of Srreptomyces hyphae is of particular interest, because here they resemble single-cell Eubacteria. This paper describes quantitatively the elongation behaviour of young germ tubes and branches of S. granaticolor. It is characterized by an ...

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INDISIM, An Individual-based Discrete Simulation Model to Study Bacterial Cultures

Gisbert

López

Valls

2002

Journal of Theoretical Biology

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The cell cycle ofEscherichia coliand some of its regulatory systems

Cited by 20 publications

References 198 publications

Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

Fundamental principles in bacterial physiology—history, recent progress, and the future with focus on cell size control: a review

Stepwise increase of elongation rate in individual hyphae of Streptomyces granaticolor during outgrowth

INDISIM, An Individual-based Discrete Simulation Model to Study Bacterial Cultures

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