The cell cycle and Wnt

Davidson, Gary

doi:10.4161/cc.9.9.11595

Cited by 20 publications

(16 citation statements)

References 8 publications

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“…The canonical Wnt/β-catenin signaling pathway has been extensively characterized as a primary driver of cell growth and proliferation [ 144 , 145 , 146 ]. During G1, Wnt signaling induces the transition to the S-phase by active transcription of c-Myc , promoting passage through the restriction point [ 145 , 147 ].…”

Section: Wnt and Cell Cyclementioning

confidence: 99%

Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

Rasmussen

Ortolano

Romero-Morales

et al. 2018

Genes

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The core transcriptional network regulating stem cell self-renewal and pluripotency remains an intense area of research. Increasing evidence indicates that modified regulation of basic cellular processes such as mitochondrial dynamics, apoptosis, and cell cycle are also essential for pluripotent stem cell identity and fate decisions. Here, we review evidence for Wnt regulation of pluripotency and self-renewal, and its connections to emerging features of pluripotent stem cells, including (1) increased mitochondrial fragmentation, (2) increased sensitivity to cell death, and (3) shortened cell cycle. We provide a general overview of the stem cell–specific mechanisms involved in the maintenance of these uncharacterized hallmarks of pluripotency and highlight potential links to the Wnt signaling pathway. Given the physiological importance of stem cells and their enormous potential for regenerative medicine, understanding fundamental mechanisms mediating the crosstalk between Wnt, organelle-dynamics, apoptosis, and cell cycle will be crucial to gain insight into the regulation of stemness.

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Section: Wnt and Cell Cyclementioning

confidence: 99%

Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

Rasmussen

Ortolano

Romero-Morales

et al. 2018

Genes

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“…CaYck2p is one of the fungal homologs of the casein kinase 1 (CK1) family of highly conserved serine/threonine kinases that are present in most eukaryotic organisms [ 26 ]. In higher eukaryotes, the CK1 family is part of the Wnt signaling pathway [ 27 ] and regulates cellular differentiation [ 28 ], membrane trafficking [ 29 ], DNA damage response [ 30 ], and circadian rhythms [ 28 ]. The Candida genome project has revealed three CK1 paralogs ( YCK2 , YCK3 , and HRR25 ) that share amino acid similarity to other fungal CK1s, such as ScYck1p and ScYck2p in Saccharomyces cerevisiae ( S1 Fig ).…”

Section: Introductionmentioning

confidence: 99%

Yeast casein kinase 2 governs morphology, biofilm formation, cell wall integrity, and host cell damage of Candida albicans

et al. 2017

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The regulatory networks governing morphogenesis of a pleomorphic fungus, Candida albicans are extremely complex and remain to be completely elucidated. This study investigated the function of C. albicans yeast casein kinase 2 (CaYck2p). The yck2Δ/yck2Δ strain displayed constitutive pseudohyphae in both yeast and hyphal growth conditions, and formed enhanced biofilm under non-biofilm inducing condition. This finding was further supported by gene expression analysis of the yck2Δ/yck2Δ strain which showed significant upregulation of UME6, a key transcriptional regulator of hyphal transition and biofilm formation, and cell wall protein genes ALS3, HWP1, and SUN41, all of which are associated with morphogenesis and biofilm architecture. The yck2Δ/yck2Δ strain was hypersensitive to cell wall damaging agents and had increased compensatory chitin deposition in the cell wall accompanied by an upregulation of the expression of the chitin synthase genes, CHS2, CHS3, and CHS8. Absence of CaYck2p also affected fungal-host interaction; the yck2Δ/yck2Δ strain had significantly reduced ability to damage host cells. However, the yck2Δ/yck2Δ strain had wild-type susceptibility to cyclosporine and FK506, suggesting that CaYck2p functions independently from the Ca+/calcineurin pathway. Thus, in C. albicans, Yck2p is a multifunctional kinase that governs morphogenesis, biofilm formation, cell wall integrity, and host cell interactions.

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“…Notably, we identified several genes involved in the Wnt/β-catenin signaling pathway, including β-catenin, the central component of the canonical Wnt/β-catenin pathway. The Wnt proteins, and the canonical Wnt/β-catenin intracellular signaling pathway, play central roles in development and disease (65), including development of the central nervous system, and are known to promote cell proliferation (66). The Wnt ligands bind to cell surface receptors of the Frizzled (Fz) and low-density lipoprotein-related protein families (67).…”

Section: Discussionmentioning

confidence: 99%

“…Myc was also identified in our screen and is a Wnt/β-catenin target gene that functions in mitosis (70). The cyclin-dependent kinase 10 was induced by leptin and is known to be modulated by Wnt/β-catenin signaling (66, 71). …”

Section: Discussionmentioning

confidence: 99%

Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions of Xenopus Tadpole Brain

2017

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In addition to its well-known role as an adipostat in adult mammals, leptin has diverse physiological and developmental actions in vertebrates. Leptin has been shown to promote development of hypothalamic circuits and to induce mitosis in different brain areas of mammals. We investigated the ontogeny of leptin mRNA, leptin actions on cell proliferation in the brain, and gene expression in the preoptic area/hypothalamus of tadpoles of Xenopus laevis. The level of leptin mRNA was low in premetamorphic tadpoles, but increased strongly at the beginning of metamorphosis and peaked at metamorphic climax. This increase in leptin mRNA at the onset of metamorphosis correlated with increased cell proliferation in the neurogenic zones of tadpole brain. We found that intracerebroventricular (i.c.v.) injection of recombinant Xenopus leptin (rxLeptin) in premetamorphic tadpoles strongly increased cell proliferation in neurogenic zones throughout the tadpole brain. We conducted gene expression profiling of genes induced at 2 h following i.c.v. injection of rxLeptin. This analysis identified 2,322 genes induced and 1,493 genes repressed by rxLeptin. The most enriched Kyoto Encyclopedia of Genes and Genomes term was the canonical Wnt/β-catenin pathway. Using electroporation-mediated gene transfer into tadpole brain of a reporter vector responsive to the canonical Wnt/β-catenin signaling pathway, we found that i.c.v. rxLeptin injection activated Wnt/β-catenin-dependent transcriptional activity. Our findings show that leptin acts on the premetamorphic tadpole brain to induce cell proliferation, possibly acting via the Wnt/β-catenin signaling pathway.

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The cell cycle and Wnt

Cited by 20 publications

References 8 publications

Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

Yeast casein kinase 2 governs morphology, biofilm formation, cell wall integrity, and host cell damage of Candida albicans

Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions of Xenopus Tadpole Brain

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