The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in pre‐eclampsia: does this indicate the mechanism of leucocyte activation?

Lyall, Fiona; Greer, Ian A.; Boswell, Fiona; Macara, Lena; Walker, James J.; Kingdom, John

doi:10.1111/j.1471-0528.1994.tb13146.x

Cited by 142 publications

(63 citation statements)

References 13 publications

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“…The significant selective elevation of sVCAM-1 in the serum of preeclamptic women observed in this study confirms the results of some recent reports [5][6][7][8] and is analogous to the previously reported increase of the vasoconstrictors endothelin-1 and von Willebrand factor in the blood of preeclamptic women 9 and to the decrease in the production of the vasodilator prostacyclin in endothelial cells. 10 Several pathways could be involved in the significant elevation of sVCAM-1 in preeclamptic women.…”

Section: Discussionsupporting

confidence: 81%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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OBJECTIVES:Maternal serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in preeclampsia to investigate whether these molecules could be helpful with regard to this pregnancy complication. STUDY DESIGN:The study population was composed of 30 preeclamptic patients with a mean gestational age of 35.5 Ϯ 4.6 weeks and 20 age-matched and gestational age-matched normotensive uncomplicated pregnancies (controls). Blood samples from 7 of the 30 preeclamptic patients and 15 of the 20 controls in the second trimester were also analyzed. Data were analyzed by parametric methods. RESULTS:Significantly higher maternal serum sVCAM-1 levels were found in both groups of preeclamptic patients with and without fetal growth restriction (981 Ϯ 145 ng/ml; n ϭ 13; p Ͻ 0.0005 and 846 Ϯ 84 ng/ml; p Ͻ 0.02, respectively) compared with controls (668 Ϯ 186 ng/ml). In contrast, no significant difference was found in maternal serum sICAM-1 levels between preeclamptic and normotensive pregnancies, or in both adhesion molecules (1) in the controls between second and third trimester samples and (2) in the second trimester between pregnant women who developed preeclampsia later and gestational age-matched controls. CONCLUSION:These findings show a selective significant elevation of maternal serum sVCAM-1 in preeclampsia, with the highest values in cases complicated with fetal growth restriction, perhaps reflecting its angiogenic function. Hence, sVCAM-1 could be helpful in the diagnosis of this fetal complication in preeclampsia.

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Section: Discussionsupporting

confidence: 81%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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“…This finding not only emphasises that PE is not merely a variant of essential hypertension but supports the concept that endothelial cells are a target in the disorder. Several markers of endothelial Increased endothelin 222 Increased prevalence of antiendothelial antibodies 80 Increased thrombomodulin 223 Increased thromboxane 224 Increased cellular fibronection (cFN) concentration a 225 Increased plasminogen activation activity (PAI-1) 226 Increased soluble VCAM 227 Increased tissue plasminogen activator 228 Increased ICAM a 229…”

Section: Journal Of Human Hypertensionmentioning

confidence: 99%

Hypertension in pregnancy

Pipkin

Roberts

2000

J Hum Hypertens

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Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking underlying hypertension, which manifests itself in later life. Pregnant women who develop de novo proteinuric hypertension (pre-eclampsia, PE) can share many risk factors with patients with the metabolic syndrome, such as obesity, dyslipidaemia and insulin resistance. However, more than half the women who develop PE remain normotensive thereafter. There is a genetic component(s) to the disease, but it is most improbable that there is a 'PE gene'. Rather, there are factors such as geneticallydetermined thrombophilias which are predisposers but not prerequisites. Impaired placentation is a feature, with inadequate invasion of the spiral arteries by syncytiotrophoblast and poor remodelling. However, similiar features are found in association with non-hypertensive

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“…Some studies reported an increase of sPselectin, sE-selectin, and sICAM-1 [18][19][20]. While others reported no changes [21,22]. In contrast, all studies have reported an increase in sVCAM-1 [21][22][23][24].…”

Section: Discussionmentioning

confidence: 86%

“…Lyall et al [21] reported that serum levels of VCAM-1 and E-selectin were not significantly different between normal and preeclamptic pregnancies. Chaiworapongsa et al [26] suggested that serum levels of ICAM-1 have no differences between normal and preeclamptic pregnancies.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies

Farzadnia

Ayatollahi

Hasan-Zade

et al. 2013

IMAS

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Abstract:Background: Preeclampsia is characterized by hypertension, dyslipidemia, and systemic inflammatory response. The aim of this study was to determine the level of serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and high-sensitive C-reactive protein (hsCRP) in preeclampsia and to compare normal pregnant, mild preeclamptic, and severe preeclamptic women. Methods: A cross-sectional study was conducted to determine the plasma concentrations of sVCAM-1 and hsCRP in peripheral blood obtained from normal pregnant (n=40), mild preeclamptic (n=37), and severe preeclamptic women (n=38). A concentration of soluble adhesion molecule was determined with enzymelinked immunosorbent assay. hsCRP was measured with immunoturbidometric. Results: There was significant difference in the means serum hsCRP between normal pregnant women and mild preeclamptic women (P<0.05). Serum concentration of hsCRP and sVCAM-1 (ng/mL) were significantly higher in severe preeclampsia (P<0.05) than normal pregnancy. There were also significant differences in hsCRP and sVCAM-1 levels between mild and severe (P<0.05). There was no difference in the mean sVCAM-1 between normal pregnant and mild preeclamptic women. Conclusion: We have determined the serum concentration of VCAM-1 and hsCRP in normal pregnancy and preeclampsia. sVCAM-1 is elevated in severe preeclampsia compared with normal pregnancy, and hsCRP is elevated in severe preeclampsia compared with mild preeclampsia and normal pregnancy.

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The cell adhesion molecule, VCAM‐1, is selectively elevated in serum in pre‐eclampsia: does this indicate the mechanism of leucocyte activation?

Cited by 142 publications

References 13 publications

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

Hypertension in pregnancy

A comparative study of vascular cell adhesion molecule-1 and high-sensitive C-reactive protein in normal and preeclamptic pregnancies

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