“…The vast majority of recent studies based on single-cell technologies have been focused on CD8+ T cells, as their role in cancer surveillance, editing and control is compelling. However, a role in tumor control is also played by the CD4+ T cell compartment, as reflected by the observation that CD4+ T cells infiltrate the tumor, and by the prognostic value of several CD4 subsets in different malignancies (152)(153)(154). Distinct CD4+ T cells subsets have been described by means of single-cell technologies, including naïve cells, memory-like cells, Th1 cells, Treg, follicular helper T cells (T FH ), and even cytotoxic effector T cells (109,111,121,141,144,146,155,156).…”