The CD24-Siglec G axis protects mice against cuprizone-induced oligodendrocyte loss: targeting danger signal for neuroprotection

Li, Ning; Zheng, Pan; Liu, Yang

doi:10.1038/cmi.2017.47

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Recent study has reported that the sialic acidebinding immunoglobulin-like lectin G (Siglec-G) binds a2,6-linked sialic acids of CD24 in the CNS. 10 Published Studies have demonstrated that Siglec-G could recruit SHP-2 and promote phosphorylation of SHP-2 to meditate intracellular signaling pathways. 31,32 Hence, we speculate that Siglec-G may be involved in CD24-mediated phosphorylation of SHP-2, which promotes post-traumatic neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury

Han

Zhou

et al. 2020

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

“…The mature protein consists of 27 to 30 amino acids and has amounts of N-and O-linked glycosylation, which is recognized by many receptors. [6][7][8][9][10] Studies have revealed that the expression of CD24 correlates with tumorigenesis and tumor progression. 11 Overexpression of CD24 can promote tissue proliferation in most tumors and autoimmune diseases.…”

mentioning

confidence: 99%

Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury

Han

Zhou

et al. 2020

Journal of Surgical Research

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“…The relation between CD24 and autoimmune disease was reported by Bai et al They found that mutation in the CD24 gene remarkably declined the risk of developing experimental autoimmune encephalomyelitis (23). In another study by Li et al, using CD24FC, a recombinant protein that binds to DAMPs and works as the agonist of Siglec G, was assessed in mice (14). Administration of CD24Fc protected mice against oligodendrocyte degeneration due to chronic exposure to cuprizone (14).…”

Section: Administration Of Cd24fc In Covid-19mentioning

confidence: 92%

“…Siglec-10 binds CD24, creating the CD24-Siglec-10 checkpoint, and regulates inflammation caused by tissue injury related to DAMPs (10). Previous studies have represented that fortified CD24-siglec-10 checkpoint could decline inflammation in joints, colon, and central nervous system (11)(12)(13)(14). In addition, a study reported that CD24 was dominantly bound to siglec-10/G on liver oval cells, revealing that CD24 protected the liver against acetaminophen-induced hepatoxicity through regulating the inflammation (15,16).…”

Section: Key Pointmentioning

confidence: 99%

Treatment of COVID-19 by CD24FC; a mini-review to the current knowledge

Dabaghi¹,

Rad²,

Saberian³

2021

J Prev Epidemiol

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The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is already known for its respiratory infection, but it involved more organs such as the kidney, liver, and heart. Most of the patients with COVID-19 have mild symptoms, but 5% of cases are admitted to an intensive care unit (ICU) for severe symptoms, including multi-organ failure and septic shock. Excessive immune responses play an essential role in sepsis development and are associated with worse prognosis in COVID-19 patients. Consequently, reduction of these immune responses may be helpful for managing COVID-19 patients. In this mini-review, we discuss the prospective role of CD24FC, as a recombinant protein with immunomodulatory function, in the treatment of COVID-19 patients and its mechanism of action in the regulation of the immune system.

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“…Similar results were recently reported in another mouse model of central nervous system degeneration. CD24‐Fc administration protected mice against cuprizone‐induced oligodendrocyte loss 136 . In both experimental settings, the CD24‐Fc stimulated the signaling of Siglec G (ie, Siglec‐10 in humans) and suppressed the inflammatory response in vivo via SHP‐1 activation.…”

Section: How Is Cd24 Expression Regulated?mentioning

confidence: 99%

Novel insights into the function of CD24: A driving force in cancer

Altevogt

Sammar

Hüser

et al. 2020

Intl Journal of Cancer

131

112

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CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by immune cells but is often overexpressed in human tumors. In cancer, CD24 is a regulator of cell migration, invasion and proliferation. Its expression is associated with poor prognosis and it is used as cancer stemness marker. Recently, CD24 on tumor cells was identified as a phagocytic inhibitor (“do not eat me” signal) having a suppressive role in tumor immunity via binding to Siglec‐10 on macrophages. This finding is reminiscent of the demonstration that soluble CD24‐Fc can dampen the immune system in autoimmune disease. In the present review, we summarize recent progress on the role of the CD24‐Siglec‐10 binding axis at the interface between tumor cells and the immune system, and the role of CD24 genetic polymorphisms in cancer. We describe the specific function of cytoplasmic CD24 and discuss the presence of CD24 on tumor‐released extracellular vesicles. Finally, we evaluate the potential of CD24‐based immunotherapy.

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The CD24-Siglec G axis protects mice against cuprizone-induced oligodendrocyte loss: targeting danger signal for neuroprotection

Cited by 7 publications

References 15 publications

Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury

Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury

Treatment of COVID-19 by CD24FC; a mini-review to the current knowledge

Novel insights into the function of CD24: A driving force in cancer

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