The CCAAT/enhancer-binding protein δ (C/EBP-δ) transcription factor is heat inducible in the cold-adapted antarctic fish Trematomus bernacchii

Sleadd, Isaac M.; Buckley, Bradley A.

doi:10.1007/s00300-012-1262-8

Cited by 9 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparative studies have shown that bLZ proteins have phylogenetically broadly conserved roles in aquatic animals exposed to stress. For instance, CCAAT enhancer binding protein (C/EBP)-delta was induced by acute heat stress and thermal acclimation in liver, white muscle and gill of the coastal goby Gillichthys mirabilis (Buckley, 2011) and in white muscle of the Antarctic Notothenioid fish Trematomus bernacchii (Sleadd & Buckley, 2013). Moreover, the jun protein was posttranslationally modified in response to osmotic stress in gills of G. mirabilis (Kültz, 1996).…”

Section: Stress-inducible Transcription Factorsmentioning

confidence: 99%

Evolution of cellular stress response mechanisms

Kültz

2020

J Exp Zool Pt A

View full text Add to dashboard Cite

The cellular stress response (CSR) is pervasive to all domains of life. It has shaped the interaction between organisms and their environment since the origin of the first cell. Although the CSR has been subject to a myriad of nuanced modifications in the various branches of life present today, its core features remain preserved. The scientific literature covering the CSR is enormous and the broad scope of this brief overview was challenging. However, it is critical to conceptually understand how cells respond to stress in a holistic sense and to point out how fundamental aspects of the CSR framework are integrated. It was necessary to be extremely selective and not feasible to even mention many interesting and important developments in this expansive field. The purpose of this overview is to sketch out general and emerging CSR concepts with emphasis on the initial cellular strain resulting from stress (macromolecular damage) and the evolutionarily most highly conserved elements of the CSR. Examples emphasize fish and aquatic invertebrates to highlight what is known in organisms beyond mammals, yeast and other common models. Nonetheless, select pioneering studies using canonical models are also considered and the concepts discussed are applicable to all cells. More detail on important aspects of the CSR in aquatic animals is provided in the accompanying articles of this special issue. This is the author manuscript accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

show abstract

Section: Stress-inducible Transcription Factorsmentioning

confidence: 99%

Evolution of cellular stress response mechanisms

Kültz

2020

J Exp Zool Pt A

View full text Add to dashboard Cite

show abstract

“…Hsps can directly block both intrinsic and extrinsic apoptotic pathways (Beere, 2005), and it is possible that inability to induce Hsps above constitutive levels may prevent apoptosis. Evidence supporting this idea includes the heat-induction of the pro-apoptotic transcription factor CCAAT/Enhancer-binding Protein Delta (C/EBP-05) in heat-stressed T. bernacchii (Sleadd and Buckley, 2013) and the fact that exposure to temperatures as low as 2°C causes apoptosis in hepatocytes from the same species (Sleadd et al, 2014).…”

Section: Responses To Long-term Heat Exposure In Eurythermsmentioning

confidence: 99%

Transcriptomic responses to environmental temperature in eurythermal and stenothermal fishes

Logan

Buckley

2015

Journal of Experimental Biology

Self Cite

135

116

View full text Add to dashboard Cite

Ectothermic species like fishes differ greatly in the thermal ranges they tolerate; some eurythermal species may encounter temperature ranges in excess of 25°C, whereas stenothermal species in polar and tropical waters live at essentially constant temperatures. Thermal specialization comes with fitness trade-offs and as temperature increases due to global warming, the physiological basis of specialization and thermal plasticity has become of great interest. Over the past 50 years, comparative physiologists have studied the physiological and molecular differences between stenothermal and eurythermal fishes. It is now well known that many stenothermal fishes have lost an inducible heat shock response (HSR). Recent advances in transcriptomics have now made it possible to examine genome-wide changes in gene expression (GE) in non-model ecologically important fish, broadening our view beyond the HSR to regulation of genes involved in hundreds of other cellular processes. Here, we review the major findings from transcriptomic studies of extreme eurythermal and stenothermal fishes in response to acute and long-term exposure to temperature, both time scales being critically important for predicting climate change responses. We consider possible molecular adaptations that underlie eurythermy and stenothermy in teleosts. Furthermore, we highlight the challenges that still face the field of comparative environmental genomics and suggest fruitful paths of future investigation.

show abstract

“…Also induced were transcription factors known to respond quickly to cellular stresses ( CCAAT/EBP β, δ and ε , KLF6 , and KLF9 ), or have relevant roles in stress response ( CREM, NFIL3, NFE2L1, NR4A1, FOXQ1 ). Of these, upregulation of the CCAAT/enhancer-binding proteins ( CCAAT/EBP ) has been inferred to be of particular importance in a heat stress study of the high-latitude nototheniid Trematomus bernacchii [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Evolution in chronic cold: varied loss of cellular response to heat in Antarctic notothenioid fish

2018

View full text Add to dashboard Cite

BackgroundConfined within the freezing Southern Ocean, the Antarctic notothenioids have evolved to become both cold adapted and cold specialized. A marked signature of cold specialization is an apparent loss of the cellular heat shock response (HSR). As the HSR has been examined in very few notothenioid species to-date, it remains unknown whether HSR loss pervades the Antarctic radiation, or whether the broader cellular responses to heat stress has sustained similar loss. Understanding the evolutionary status of these responses in this stenothermal taxon is crucial for evaluating its adaptive potential to ocean warming under climate change.ResultsIn this study, we used an acute heat stress protocol followed by RNA-Seq analyses to study the evolution of cellular-wide transcriptional responses to heat stress across three select notothenioid lineages - the basal temperate and nearest non-Antarctic sister species Eleginops maclovinus serving as ancestral proxy, the cryopelagic Pagothenia borchgrevinki and the icefish Chionodraco rastrospinosus representing cold-adapted red-blooded and hemoglobinless Antarctic notothenioids respectively. E. maclovinus displayed robust cellular stress responses including the ER Unfolded Protein Response and the cytosolic HSR, cementing the HSR as a plesiomorphy that preceded Antarctic notothenioid radiation. While the transcriptional response to heat stress was minimal in P. borchgrevinki, C. rastrospinosus exhibited robust responses in the broader cellular networks especially in inflammatory responses despite lacking the classic HSR and UPR.ConclusionThe disparate patterns observed in these two archetypal Antarctic species indicate the evolutionary status in cellular ability to mitigate acute heat stress varies even among Antarctic lineages, which may affect their adaptive potential in coping with a warming world.Electronic supplementary materialThe online version of this article (10.1186/s12862-018-1254-6) contains supplementary material, which is available to authorized users.

show abstract

The CCAAT/enhancer-binding protein δ (C/EBP-δ) transcription factor is heat inducible in the cold-adapted antarctic fish Trematomus bernacchii

Cited by 9 publications

References 44 publications

Evolution of cellular stress response mechanisms

Evolution of cellular stress response mechanisms

Transcriptomic responses to environmental temperature in eurythermal and stenothermal fishes

Evolution in chronic cold: varied loss of cellular response to heat in Antarctic notothenioid fish

Contact Info

Product

Resources

About