The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients

Jakubczyk, Andrzej; Wrzosek, Małgorzata; Łukaszkiewicz, Jacek; Sadowska-Mazuryk, Joanna; Matsumoto, Halina; Śliwerska, Elżbieta; Glass, Jennifer M.; Burmeister, Margit; Brower, Kirk J.; Wojnar, Marcin

doi:10.1016/j.jpsychires.2011.09.001

Cited by 46 publications

(33 citation statements)

References 38 publications

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“…After discarding the references that clearly did not meet the criteria, the studies were then filtered to ensure conformity with our inclusion criteria. Two studies (Jakubczyk et al 2011; Wrzosek et al 2011) were excluded because no data of matched normal controls were described, and one study (Yang et al 2012) was excluded because the genotype data was same as that described in another study (Yang et al 2010). Finally, 21 studies, composed of 20 case-control studies and one HRR study (Hill et al 2002), met our criteria for inclusion.…”

Section: Resultsmentioning

confidence: 99%

Association of the HTR2A gene with alcohol and heroin abuse

et al. 2013

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Positive genetic associations of rs6313 (102T/C at exon 1) and rs6311 (-1438A/G) on the 5-hydroxytryptamine (serotonin) 2A receptor gene (HTR2A or 5-HT2A) were reported for alcohol and drug abuse, however, other association studies failed to produce consistent results supporting the susceptibility of the two single nucleotide polymorphisms (SNPs). To clarify the associations of the HTR2A gene with substance use disorders, we performed a meta-analysis based on the genotypes from the available candidate gene association studies of the two SNPs with alcohol and drug abuse from multiple populations. Evidence of association was found for HTR2A rs6313 in all the combined studies (e.g., allelic P = 0.0048 and OR = 0.86, 95% CI 0.77 – 0.95) and also in the combined studies of alcohol dependence (abuse) (e.g., allelic P = 0.0001 and OR = 0.71, 95% CI 0.59 – 0.85). The same association trend was also observed in the SAGE (Study of Addiction: Genetics and Environment) datasets. The meta-analysis supports a contribution of the HTR2A gene to the susceptibility to substance use disorders, particularly alcohol dependence.

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Section: Resultsmentioning

confidence: 99%

Association of the HTR2A gene with alcohol and heroin abuse

et al. 2013

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“…54 It is also a significant predictor of cocaine, 55 opioid, 56 and alcohol abuse or dependence. 57 Finally, note that no psychiatric diagnosis measured in our study was a predictor of substance dependence according to the multiple logistic regression model. An explanation could be that substance dependence precedes the appearance of a possible mental disorder-but other longitudinal studies are needed to validate this hypothesis.…”

Section: 40mentioning

confidence: 64%

Predictors of Alcohol and Drug Dependence

Fleury¹,

Bamvita

Perreault

et al. 2014

Can J Psychiatry

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Objective: Our study sought to identify sociodemographic, clinical, life perception, and service use characteristics that distinguish new cases of people dependent on substances from the general population; and to determine predictors of substance dependence over a 2-year period. Variables that differentiate people dependent on substances according to sex and age were also assessed. Methods:Among 2434 people who took part in an epidemiologic catchment area health survey at baseline, 2.2% were identified with substance dependence at the second measurement time only. Using a comprehensive framework, various aspects were considered as predictors for multivariate statistics.Results: Participants with substance dependence at time 2 only showed worse clinical conditions, life events, life and health perception, and neighbourhood characteristics than other participants, but only 2.5% used health care services. Male sex, younger age, stigmatization, and impulsiveness were predictors of substance dependence. Regarding sex, females with dependence were only more likely to suffer from social phobia than males. In terms of age categories, participants over 50 with substance dependence were more likely to have a lower household income and less social support than younger people. Conclusion:Stigmatization was the strongest predictor of substance dependence. Our study also confirmed that males and younger people were more likely to have substance dependence. Anti-stigmatization, prevention, and outreach programs are needed to overcome the reluctance of this clientele to use health care services. Health professionals should also pay more attention to life and health perception and neighbourhood characteristics of newly identified drug users. W W W Prédicteurs de la dépendance à l'alcool et aux droguesObjectif : Notre étude cherchait à identifier les caractéristiques sociodémographiques, cliniques, et liées à la perception de la vie comme à l'utilisation des services qui distinguent les nouveaux cas de personnes dépendantes aux substances de la population générale; et à déterminer les prédicteurs de la dépendance aux substances sur une période de 2 ans. Les variables qui différencient les personnes dépendantes aux substances selon le sexe et l'âge ont aussi été évaluées.Méthodes : Chez 2434 personnes qui ont pris part à une enquête de santé épidémiologique d'un secteur hospitalier au départ, 2,2 % ont été identifiées comme ayant une dépendance aux substances au deuxième temps de mesure seulement. À l'aide d'un cadre détaillé, divers aspects ont été étudiés en tant que prédicteurs de statistiques multivariées.Résultats : Les participants ayant une dépendance aux substances au temps 2 seulement présentaient des conditions cliniques, des événements de vie, des perceptions de la vie

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“…Specifically, Jakubczyk et al (2012) found that the minor allele of rs6313 was associated with better response inhibition on the stop signal task in a sample of alcohol-dependent individuals. Similarly, Bjork et al (2002) found that the minor allele was associated with better response inhibition on a continuous performance task in a sample of adults with histories of depression or substance abuse.…”

Section: Discussionmentioning

confidence: 99%

Hierarchical investigation of genetic influences on response inhibition in healthy young adults.

Weafer¹,

Gray²,

Hernandez³

et al. 2017

Experimental and Clinical Psychopharmacology

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Poor inhibitory control is a known risk factor for substance use disorders, making it a priority to identify the determinants of these deficits. The aim of the current study was to identify genetic associations with inhibitory control using the stop signal task in a large sample (n=934) of healthy young adults of European ancestry. We genotyped the subjects genome-wide and then used a hierarchical approach in which we tested: 1) 7 a priori single nucleotide polymorphisms (SNPs) previously associated with stop signal task performance; 2) ~9,000 SNPs designated as high-value addiction (HVA) markers by the SmokeScreen© array; and 3) ~5M genotyped and imputed SNPs, followed by a gene-based association analysis utilizing the resultant p-values. A priori SNP analyses revealed nominally significant associations between response inhibition and one locus in HTR2A (rs6313; p = 0.04, dominance model, uncorrected) in the same direction as prior findings. A nominally significant association was also found in one locus in ANKK1 (rs1800497; p = 0.03, uncorrected), although this was in the opposite direction of previous reports. After accounting for multiple comparisons, the HVA, genome-wide, and gene-based analyses yielded no significant findings. This study implicates variation in serotonergic and dopaminergic genes, but also underscores the difficulty of detecting the influence of individual SNPs, even when biological information is used to prioritize testing. While such small effect sizes suggest limited utility of individual SNPs in predicting risk for addiction or other impulse control disorders, they may nonetheless shed light on complex biological processes underlying poor inhibitory control.

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The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients

Cited by 46 publications

References 38 publications

Association of the HTR2A gene with alcohol and heroin abuse

Association of the HTR2A gene with alcohol and heroin abuse

Predictors of Alcohol and Drug Dependence

Hierarchical investigation of genetic influences on response inhibition in healthy young adults.

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