The CBC: Reference Ranges for Neonates

Determination of Hematocrit Interference in Blood Samples Derived from Patients with Different Blood Glucose Concentrations

“…18 The practical relevance of HCT interference has been investigated only in high-risk populations (e.g., intensive care unit or neonatal patients), but information from community-based studies is lacking. 21 Recently, a first thorough investigation of the HCT distribution in an urban community has been published demonstrating a range 30-50% in Using artificially produced samples in a laboratory setting, we have been able to demonstrate that devices employing dynamic electrochemistry are unaffected by HCT variation. 10,12 Laboratory tests with devices employing dynamic electrochemistry, however, require an extremely careful handling of the sample.…”

“…One known interfering substance is blood viscosity as determined by the HCT value, 18−20 which can be eliminated by direct HCT measurement and appropriate correction of the obtained signal 11,21 or by application of a mathematical correction for HCT interference by means of assessment of the different kinetics involved in the different confounding signals under different measurement conditions as employed by dynamic electrochemistry. 13,22 Prevalence of HCT variation is usually underestimated by physicians and diabetes nurse educators and is subject to seasonal variation.…”

Association of cord blood platelet count and volume with hemoglobin in healthy term infants

“…10 Recently, neonatal reference ranges were defined in a large multi-hospital system with a single type of hematology analyzer. 11 Typically, the type of cell analyzer and its principles of measurement are given in association with the results for cellular characteristics because the results are, to some extent, depending on the principles and software used in the analysis. [12][13][14] Some measurements are independent of each other, such as hemoglobin (Hb) concentration and cell counts other than red blood cells (RBCs).…”

Evaluating neonatal hyperbilirubinemia in late preterm Hispanic twins led to the diagnosis of hereditary spherocytosis in them, and in their sibling and in their mother

“…The mean corpuscular volume and mean corpuscular hemoglobin and all other complete blood count values were within the reference ranges for the neonates at Intermountain Healthcare, published previously. 8 The exception was the red cell distribution width, which was elevated in both: 20.3 and 22.4 (reference range 16.6 to 17.8). At 124 h after birth, the reticulocyte count on Twin A was 9.9% (367 000 ml À1 ) and immature reticulocyte fraction 0.54; on Twin B these measurements were 7.7% (285 000 ml À1 ) and 0.47, respectively.…”