The CB1receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Carlos Costas-Insua,
Alba Hermoso-López,
Estefanía Moreno
et al.
Abstract:Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene cause a form of autosomal recessive non-syndromic intellectual disability (ARNSID) that is modelled by knocking-out the mouse Crbn gene. A reduction in excitatory neurotransmission has been proposed as an underlying mechanism of the disease, but the intimate factors eliciting this impairment remain mostly unknown. Here we report that CRBN molecules selectively… Show more
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