The cause of post-traumatic pulmonary insufficiency in man

Fulton, Robert L.; Jones, Christina

doi:10.1097/00005373-197508000-00022

Cited by 18 publications

(31 citation statements)

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“…The most commonly involved pathogens are: Pseudomona aeruginosa, Escherichia coli, Klebsiella pneumoniae and Acinetobacter, although in patients with head trauma Staphylococcus aureus is the most common one. 30 Independent risk factors for the development of VAP are: low level of consciousness, aspiration, emergency intubation, mechanical ventilation for more than 3 days, reintubation, age over 60 years, supine position, comorbidities and previous antibiotic therapy. 30 Mortality rates attributed to VAP are about 30%; this condition doubles the risk of death.…”

Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

“…30 Independent risk factors for the development of VAP are: low level of consciousness, aspiration, emergency intubation, mechanical ventilation for more than 3 days, reintubation, age over 60 years, supine position, comorbidities and previous antibiotic therapy. 30 Mortality rates attributed to VAP are about 30%; this condition doubles the risk of death. It is also estimated to increases the duration of stay at the ICU in 6 days and the associated expenses in 10,000 dollars.…”

Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

“…It is also estimated to increases the duration of stay at the ICU in 6 days and the associated expenses in 10,000 dollars. 30 Mechanical ventilation is the main supportive therapy used to re-establish sufficient oxygen supply and remove Carbon dioxide (CO 2 ) produced by peripheral organs during acute respiratory failure in patients with severe brain injury. While tight CO 2 control represents a priority in patients with severe brain injury, optimal treatment of ALI/ARDS consists of a protective ventilatory strategy allowing a certain degree of hypercapnia to protect the lung from further injurious stimuli while it recovers from the initial pathological process.…”

Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary Complications in Patients with Brain Injury

Alvarez¹,

Quevedo²,

Furelos³

et al. 2015

Pulm Res Respir Med Open J

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Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

Section: Pneumonia Associated With Mechanical Ventilationmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary Complications in Patients with Brain Injury

Alvarez¹,

Quevedo²,

Furelos³

et al. 2015

Pulm Res Respir Med Open J

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“…Pulmonary dysfunction is, however, a wellknown complication of severe head injury in adults [2], Acute respiratory failure is re ported in 20% of patients where the traumatic injury was confined to the central nervous sys tem [3], Several studies have shown that more than 85% of patients with severe head injury show an increase in the alveolar-to-arterial oxygen gradient P(A-a)C>2 as well as other car diovascular effects [4][5][6], The exact mecha nism behind this phenomenon is not known. Studies in animal models have, however, shown that intracistemal injection of fibrin produces lung edema known as neurogenic pulmonary edema [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Intraventricular Hemorrhage on Pulmonary Function in Newborn Piglets

Farstad

Odden²,

Bratlid³

1994

Neonatology

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Intracranial hemorrhage in the premature infant is often associated with respiratory failure and need for mechanical ventilation. We therefore addressed the question of possible interactions with and pulmonary consequences of intraventricular hemorrhage. Newborn piglets were studied during intraventricular hemorrhage simulated by intraventricular blood infusion. Infusion volume amounted to 8% of estimated brain weight. Respiratory rate, minute ventilation, lung resistance and dynamic lung compliance, as well as arterial blood gases, arterial and intraventricular pressures were measured. The piglets were mechanically ventilated with a low basal rate of 20 breaths per minute throughout the study. All piglets experienced significant rise in intraventricular pressure and respiratory failure during the study. Respiratory failure was mainly a result of a reduction in respiratory frequency and minute ventilation until apnea. However, a rise in lung resistance was also noted while lung compliance did not change. We conclude that increased need for mechanical ventilation during intracranial hemorrhage is primarilty a consequence of hypoventilation. The increase seen in lung resistance could also suggest that intraventricular hemorrhage causes an element of bronchiolar constriction. Furthermore, these effects are not only a result of the increase in intraventricular pressure, but specific effects of blood components within the central nervous system must be considered.

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“…Вместе с тем, одним из первых органов «мишеней», подвергающихся повреждению, являются легкие с развитием респираторного дистресс синдрома взрослых (РДСВ) [7].…”

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Multiorgan Dysfunction: the State-of-the-Art and Current Approaches to Its Treatment Using Low Flow-Rate Membrane Technologies

Danilov¹,

М²

2011

rmt

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Данный аналитический обзор литературы обобщает имеющиеся на настоящее время данные по лечению полиорганной недостаточности (ПОН). В обзоре описывается патогенез, пусковые механизмы и компоненты ПОН, а также совре менные подходы к лечению данной патологии с помощью современных мембранных технологий. Ключевые слова: МАРС терапия, низкопоточная пролонгированная вено венозная гемодиафильтрация, полиорганная недостаточность. This analytical literature review generalizes the currently available data on the treatment of multiorgan dysfunction (MOD).The review describes the pathogenesis, triggers, and components of MOD, as well as current approaches to treating this pathology with up to date technologies.

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The cause of post-traumatic pulmonary insufficiency in man

Cited by 18 publications

References 0 publications

Pulmonary Complications in Patients with Brain Injury

Pulmonary Complications in Patients with Brain Injury

Effect of Intraventricular Hemorrhage on Pulmonary Function in Newborn Piglets

Multiorgan Dysfunction: the State-of-the-Art and Current Approaches to Its Treatment Using Low Flow-Rate Membrane Technologies

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