The cause of cancer: The unifying theory

Majérus, Marie-Ange

doi:10.1016/j.adcanc.2022.100034

Cited by 8 publications

(3 citation statements)

References 162 publications

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“…Previous research indicates that, in carcinogenesis, the activity of many genes is disrupted, especially those involved in the processes of angiogenesis, adhesion, proliferation, immune response, proteolysis, differentiation, and cell death [1]. Despite the spectacular contribution that molecular biology has made in the field of carcinogenesis over the last half-century, mortality due to cancer declined by almost 30% [2].…”

Section: Introduction 1carcinogenesis and Molecular Biologymentioning

confidence: 99%

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells

Ziemiński,

Stupak,

Kwiatek

et al. 2024

Cells

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Previous research indicates that carcinogenesis involves disrupting the functions of numerous genes, including factors involved in the regulation of transcription and cell proliferation. For these reasons, in endometrial carcinogenesis, we decided to investigate the expression of TSG101 (a suppressor of tumor transformation) and LSF (a transcription factor involved in numerous cellular processes, such as cell cycle regulation, cell growth, development, and apoptosis). LSF may be involved in the regulation of TSG101 expression. The research material consisted of endometrial cancer samples from 60 patients. The control group consisted of normal endometrium samples donated by 60 women undergoing surgery for benign diseases of the female reproductive organs. The samples were subjected to immunohistochemical staining with antibodies specific to TSG101 and LSF. Specific antibodies were used to identify TSG101 and LSF in the examined histopathological preparations. An approximately 14-fold lower risk of endometrial cancer development was observed in patients with TSG expression in more than 75% of the assessed cells (4% vs. 36%; OR = 0.07; p = 0.0182). There was a four-fold lower risk of endometrial cancer development in patients with LSF expression in more than 50% of the assessed cells (32% vs. 64%; OR = 0.26; p = 0.0262). A more than three-fold lower risk of endometrial cancer development was observed in patients with LSF expression in more than 75% of the assessed cells (24% vs. 52%; OR = 0.29; p = 0.0454). Endometrial cancer was diagnosed in those with a lower level of TSG101 expression than in those with a cancer-free endometrium. Decreased expression of TSG101 may be a marker of endometrial cancer, and increased expression of LSF when diagnosed with endometrial cancer may indicate greater advancement of the disease. These markers might be used as diagnostic and prognostic markers—however, there is a lack of a correlation between them.

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Section: Introduction 1carcinogenesis and Molecular Biologymentioning

confidence: 99%

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells

Ziemiński,

Stupak,

Kwiatek

et al. 2024

Cells

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“…Despite the therapeutic advances of the last century, inter alia, chemotherapy, radiotherapy, and immunology, cancer's incidence and mortality continue to rise. Many theories have been proposed to explain the origin of cancer [1]. In the 1920s, the mitochondrial metabolic theory suggested that cancer is caused by a disorder in cellular respiration [2,3].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

Martinez,

Baghli,

Gourjon

et al. 2024

Metabolites

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The cancer paradigm is generally based on the somatic mutation model, asserting that cancer is a disease of genetic origin. The mitochondrial–stem cell connection (MSCC) proposes that tumorigenesis may result from an alteration of the mitochondria, specifically a chronic oxidative phosphorylation (OxPhos) insufficiency in stem cells, which forms cancer stem cells (CSCs) and leads to malignancy. Reviewed evidence suggests that the MSCC could provide a comprehensive understanding of all the different stages of cancer. The metabolism of cancer cells is altered (OxPhos insufficiency) and must be compensated by using the glycolysis and the glutaminolysis pathways, which are essential to their growth. The altered mitochondria regulate the tumor microenvironment, which is also necessary for cancer evolution. Therefore, the MSCC could help improve our understanding of tumorigenesis, metastases, the efficiency of standard treatments, and relapses.

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“…The exploration of natural plants for their therapeutic potential, particularly in cancer treatment, remains a prominent challenge in modern times, with a focus on developing effective drugs to combat tumors and cancer [9]. The complex and diverse chemical structures of natural products offer promising avenues for the prevention and treatment of diseases, highlighting their importance in addressing critical health issues like cancer [10].…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

Elfardi,

El Boukhari,

Fatimi

et al. 2024

DDC

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Plants and plant extracts have long been acknowledged as valuable resources for the development of therapeutic formulations for various diseases. Among them, numerous plants and plant-derived products have demonstrated cytotoxic and/or anti-tumor properties. Saffron, particularly due to its major compounds, namely crocin, crocetin, and safranal, stands out as a promising candidate in this regard. Our research undertakes a literature review, reaffirming the antioxidant, anti-inflammatory, and, notably, anti-tumor properties of saffron and its major constituents. Additionally, this study examines relevant patent documents, highlighting innovative applications for saffron and its major compounds in cancer therapy. The review discusses the progress in purifying the compounds extracted from saffron and assesses their impact on cytotoxic trial outcomes, the potential synergies between certain saffron compounds and established cytotoxic molecules, and the limitations of the patents examined, particularly concerning reported clinical evidence. Researchers who focus on advances in oncology will know from our findings the evolution of the patent landscape regarding cytotoxic and/or anti-tumor therapeutic applications using saffron or its main compounds. Moreover, investigators can draw inspiration from patents leveraging traditional knowledge, particularly from Chinese medicine, to clarify specific active molecules and their mechanisms of action and can expedite the translation of these findings into clinically relevant interventions, potentially enhancing cancer therapy outcomes.

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The cause of cancer: The unifying theory

Cited by 8 publications

References 162 publications

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells

Mitochondrial–Stem Cell Connection: Providing Additional Explanations for Understanding Cancer

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

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