The Cause–Effect Dilemma of Hematologic Changes in COVID-19: One Year after the Start of the Pandemic

Youssry, Ilham; Elaziz, Dalia Abd; Ayad, Nardeen; Eyada, Iman

doi:10.3390/hematolrep14020014

Cited by 3 publications

(2 citation statements)

References 59 publications

(82 reference statements)

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“…COVID-19 determines various haemostatic abnormalities; among these, the most frequent are mild thrombocytopenia [ 38 , 39 , 74 , 75 ] and increased levels of D-dimer [ 40 , 41 , 76 , 77 ]. Patients who experience this type of heamostatic abnormality develop an increased risk of being admitted to intensive care for mechanical ventilation.…”

Section: Hemostasis Parameters During Covid-19mentioning

confidence: 99%

Thromboembolic Disease and Cardiac Thrombotic Complication in COVID-19: A Systematic Review

Nappi

Gambardella

et al. 2022

Metabolites

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The coronavirus 2019 pandemic has affected many healthcare systems worldwide. While acute respiratory distress syndrome (ARDS) has been well-documented in COVID-19, there are several cardiovascular complications, such as myocardial infarction, ischaemic stroke, and pulmonary embolism, leading to disability and death. The link between COVID-19 and increasing thrombogenicity potentially occurs due to numerous different metabolic mechanisms, ranging from endothelial damage for direct virus infection, associated excessive formation of neutrophil extracellular traps (NETs), pathogenic activation of the renin-angiotensin-aldosterone system (RAAS), direct myocardial injury, and ischemia induced by respiratory failure, all of which have measurable biomarkers. A search was performed by interrogating three databases (MEDLINE; MEDLINE In-Process and Other Non-Indexed Citations, and EMBASE). Evidence from randomized controlled trials (RCT), prospective series, meta-analyses, and unmatched observational studies were evaluated for the processing of the algorithm and treatment of thromboembolic disease and cardiac thrombotic complications related to COVID-19 during SARS-CoV-2 infection. Studies out with the SARS-Cov-2 infection period and case reports were excluded. A total of 58 studies were included in this analysis. The role of the acute inflammatory response in the propagation of the systemic inflammatory sequelae of the disease plays a major part in determining thromboembolic disease and cardiac thrombotic complication in COVID-19. Some of the mechanisms of activation of these pathways, alongside the involved biomarkers noted in previous studies, are highlighted. Inflammatory response led to thromboembolic disease and cardiac thrombotic complications in COVID-19. NETs play a pivotal role in the pathogenesis of the inflammatory response. Despite moving into the endemic phase of the disease in most countries, thromboembolic complications in COVID-19 remain an entity that substantially impacts the health care system, with long-term effects that remain uncertain. Continuous monitoring and research are required.

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Section: Hemostasis Parameters During Covid-19mentioning

confidence: 99%

Thromboembolic Disease and Cardiac Thrombotic Complication in COVID-19: A Systematic Review

Nappi

Gambardella

et al. 2022

Metabolites

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“…Additionally, the hypercoagulation and inflammatory state lead to more fragility and make elastic the membrane of RBC ( Grobler et al, 2020 ). It has been demonstrated that high serum ferritin levels in COVID-19 patients might result in hyper-activated interactions between erythrocytes and platelets ( Youssry et al, 2022 ), indicating a connection between erythrocyte alterations and thrombosis in COVID-19 disease ( Venter et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Modulation in serum and hematological parameters as a prognostic indicator of COVID-19 infection in hypertension, diabetes mellitus, and different cardiovascular diseases

Jan,

Anwar Khan,

Khan

et al. 2024

Front. Chem.

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SARS-CoV-2 infection affects and modulates serum as well as hematological parameters. However, whether it modifies these parameters in the existing disease conditions, which help in the erection of specific treatments for the disease, is under investigation. Here, we aimed to determine whether serum and hematological parameters alteration in various diseases, diabetes mellitus (DM), hypertension (HTN), ischemic heart disease (IHD) and myocardial infarction (MI) conditions correlate and signal SARS-CoV-2 infection, which could be used as a rapid diagnosis tool for SARS-CoV-2 infection in disease conditions. To assess the projected goals, we collected blood samples of 1,113 male and female patients with solo and multiple disease conditions of DM/HTN/IHD/MI with severe COVID-19, followed by biochemical analysis, including COVID-19 virus detection by RT-qPCR. Furthermore, blood was collected from age-matched disease and healthy individuals 502 and 660 and considered as negative control. In our results, we examined higher levels of serum parameters, including D-dimer, ferritin, hs-CRP, and LDH, as well as hematological parameters, including TLC in sole and multiple diseases (DM/HTN/IHD/MI) conditions compared to the control subjects. Besides, the hematological parameters, including Hb, RBC, and platelet levels, decreased in the patients. In addition, we found declined levels of leukocyte count (%), lymphocyte (%), monocyte (%), and eosinophil (%), and elevated level of neutrophil levels (%) in all the disease patients infected with SARS-CoV-2. Besides, NLR and NMR ratios were also statistically significantly (p < 0.05) high in the patients with solo and multiple disease conditions of DM/HTN/IHD/MI infected with the SARS-CoV-2 virus. In conclusion, rapid alteration of sera and hematological parameters are associated with SARS-CoV-2 infections, which could help signal COVID-19 in respective disease patients. Moreover, our results may help to improve the clinical management for the rapid diagnosis of COVID-19 concurrent with respective diseases.

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SARS-CoV-2 infection augments species- and age-specific predispositions in cotton rats

Boukhvalova

Mortensen

Caple

et al. 2023

Sci Rep

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Heterogeneity of COVID-19 manifestations in human population is vast, for reasons unknown. Cotton rats are a clinically relevant small animal model of human respiratory viral infections. Here, we demonstrate for the first time that SARS-CoV-2 infection in cotton rats affects multiple organs and systems, targeting species- and age-specific biological processes. Infection of S. fulviventer, which developed a neutralizing antibody response and were more susceptible to SARS-CoV-2 replication in the upper respiratory tract, was accompanied by hyperplasia of lacrimal drainage-associated lymphoid tissue (LDALT), a first known report of mucosa-associated lymphoid tissue activation at the portal of SARS-CoV-2 entry. Although less permissive to viral replication, S. hispidus showed hyperplasia of bone marrow in the facial bones and increased pulmonary thrombosis in aged males. Augmentation of these features by SARS-CoV-2 infection suggests a virus-induced breach in regulatory mechanisms which could be devastating for people of all ages with underlying conditions and in particular for elderly with a multitude of ongoing disorders.

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The Cause–Effect Dilemma of Hematologic Changes in COVID-19: One Year after the Start of the Pandemic

Cited by 3 publications

References 59 publications

Thromboembolic Disease and Cardiac Thrombotic Complication in COVID-19: A Systematic Review

Thromboembolic Disease and Cardiac Thrombotic Complication in COVID-19: A Systematic Review

Modulation in serum and hematological parameters as a prognostic indicator of COVID-19 infection in hypertension, diabetes mellitus, and different cardiovascular diseases

SARS-CoV-2 infection augments species- and age-specific predispositions in cotton rats

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