The Causative Agent of Proliferative Kidney Disease May Be a Member of the Haplosporidia

Seagrave, Chris; Bucke, D.; Alderman, D. J.

doi:10.1007/978-3-642-67854-7_28

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…21, indicating that continual exposure is not needed to induce heavy infections. A mechanism for the development of the daughter cells by internal cleavage was reported by Seagrave et al (1980b). However, binary fission of the internal daughter cells, as reported in the present study, is a second method for vegetative development.…”

Section: Discussionsupporting

confidence: 64%

Development of the PKX myxosporean in rainbow trout Salmo gairdneri

Kent¹,

Hedrick²

1985

Dis. Aquat. Org.

101

122

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Sequenhal development of PKX, the causative agent of prohferahve h d n e y dlsease, is descnbed in rainbow trout Salmo ga~rdnen hchardson by light and electron mlcroscopy Fish were exposed to water contaming the infechous stage of PKX and the parasite was detected 3 wk later Parasites were prominent the following week and they mulhplied by endogeny, binary fission and possibly plasmotomy in the blood and h d n e y intershhum Intershbal nephnbs that is typically assoclated \nth PKD was fust observed 5 wk after exposure and was most prominent between 8 to 11 wk At 7 wk parasites were found in the lumens of the tubules, many were daughter cells released from PKX Myxosporean sporoblasts formed within these daughter cells (enveloping cells) The sporoblasts consisted of 6 cells and some organized into spores w~t h 2 spherical polar capsules Although the spores persisted for several months after the interstitial PKX and assoclated inflammation had subsided they dld not complete their development They remained within the enveloping cell and apparently dld not form complete valves Because only incomplete spores were observed salmonids may be abnormal hosts and the preclse taxonomic status of PKX was not determined Epizoohological and sequential development data support the hypothesis that the interstitial form of PKX and the intraluminal myxosporeans belong to the same organism

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Section: Discussionsupporting

confidence: 64%

Development of the PKX myxosporean in rainbow trout Salmo gairdneri

Kent¹,

Hedrick²

1985

Dis. Aquat. Org.

101

122

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“…Structures resembling haplosporosomes are not confined to haplosporidians, but also occur in Pararnyxa paradoxa (Desportes 1981), in the vegetative stages of myxozoans (Smith et al 1984, Kent & Hedrick 1985, Lom et al 1989, and in the primary cells of Marteilia sydneyi and its relatives (Perkins 1976 (Perkins 1969, Desportes & Nashed 1983, Smith et al 1984, Azevedo & Corral 1987, Larsson 1987, Lom et al 1989, from dense or formative inclusions derived from the spherule (Perkins 1975, Marchand & Sprague 1979, Ball 1980, Ormieres 1980, La Haye et al 1984, Hillman et al 1990), or from MVB (Perkins 1968, 1976, Perkins & Wolf 1976, Seagrave et al 1980, Desportes 1981.…”

Section: Discussionmentioning

confidence: 99%

Interrelationships of cytoplasmic structures in Bonamia sp. (Haplosporidia) infecting oysters Tiostrea chilensis: an interpretation

Hine¹,

Wesney²

1992

Dis. Aquat. Org.

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Reticular structures, confronting cisternae (CC), including cylindrical confronting cisternae (CCC), an unusual surface projection, formation of haplosporosome-like bodies (H-LB) and haplosporogenesis are described from Bonamia sp. infecting oysters Tiostrea chilensis from New Zealand. Formation of H-LB began when balls of putative nuclear material derived from indentations in the nuclear surface were encircled by cisternae of Golgi bearing a layer of dense material on their inner, concave surface. Also. H-LB were formed when CC split longitudinally and putative nuclear material filled the lumen of the resultant tubular structure, which subsequently pinched off H-LB. Haplosporogenesis began with the formation of cytoplasmic multi-vesicular bodies (MVB), which filled with dark osmiophilic material derived from nearby Golgi. The characteristic membranes of haplosporosomes appeared to form within these MVBs. It is suggested that H-LB are unusual structures in haplosporidans and that their core is formed from nuclear material. The CC from which they may form are also unusual, and in mammals CC occur in rapidly divid~ng or diseased cells. As CCC can only be induced in virally infected, transformed or neoplastic mammalian cells, it is considered that in Bonamia sp. CCC may be overt signs of an underlying disease. The significance of this is discussed in relation to the sudden appearance and pathogenicity of Bonamia sp. and, possibly, Haplosporidium nelsonj (MSX).

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“…The primary cell wall looked structurally similar to that found in Marteilia species and also in the genera Minchinia and Urosporidium. Because of these similarities, Seagrave et al (1980b) considered that the PKX cell might be a member of the Haplosporidia, now reclassified in the order Occlusosporida (Levine, Corliss, Cox, Deroux, Grain, Honigberg, Leedale, Loeblich, Lom, Lynn, Merinfeld, Page, Poljansky, Sprague, Vavra & Wallace 1980; Sprague 1982). As they were unable to find a spore stage, Seagrave et al (1980b) were unable to give a more precise classification.…”

Section: Aetiologymentioning

confidence: 99%