The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback

Li, Sijin; Xie, Hui; Zheng, Zixin; Chen, Weimao; Xu, Feng; Hu, Xiaoqing; Zhang, Dandan

doi:10.1002/hbm.25824

Cited by 27 publications

(23 citation statements)

References 95 publications

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“…Of these, 19 studies fulfilled the eligibility criteria. Amongst them, we did not receive a response from the corresponding author about the missing data in one study [ 43 ], and the authors of other study were unable to provide data until three months later due to isolation [ 69 ]. Finally, 17 studies were included in the meta-analysis [ 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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(1) Background: Emotion regulation (ER) is regarded as a core treatment target for depression and other mental illnesses. In recent years, non-invasive brain stimulation (NIBS) has been extensively used as an intervention for mental illnesses, but there has been no systematic review conducted regarding its effect on emotion regulation. Therefore, we conducted a meta-analysis of the effectiveness of NIBS for emotion regulation; (2) Methods: Systematic searches were conducted in Embase, Web of Science, PubMed, and Cochrane Library. We analyzed the effects of NIBS on tasks assessing emotion regulation using a random-effects model, and further explored the moderating role of the following factors on transcranial direct current stimulation (tDCS) studies by conducting subgroup analyses and meta-regression: target electrode placement, return electrode placement, current intensity, target electrode size, and duration of intervention; (3) Results: A total of 17 studies were included. Our meta-analysis indicated a small but significant effect of NIBS on the downregulation of negative emotions. Separate analyses indicated that repetitive transcranial magnetic stimulation (rTMS) had a medium and significant effect on the downregulation of negative emotions, whereas tDCS had no significant effect. Subgroup analyses showed that the effect of tDCS was moderated by target and return electrode placemen; (4) Conclusions: These results indicate that NIBS had a positive effect on the downregulation of negative emotions. The stimulation protocols should be carefully considered and the underlying mechanisms should be further explored.

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Section: Resultsmentioning

confidence: 99%

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Zhang

Liu

et al. 2022

Brain Sciences

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“…Many studies have suggested the association between activation of rVLPFC and self-reported negative emotions (Eisenberger et al, 2003;Phan et al, 2005;Masten et al, 2009), as well as reappraisal success (Wager et al, 2008). Also, a previous study in our laboratory has provided causal evidence to support the critical role of the rVLPFC in reappraisal outcome (He Z. et al, 2018;He et al, 2020a,b;Li et al, 2022). It is well-known that the rVLPFC is an essential region in the inhibition process (Aron et al, 2004;Leung and Cai, 2007;Levy and Wagner, 2011;Rae et al, 2015;Apšvalka et al, 2022), which is usually observed in the Go/No-go, Think/No-think, and Stop Signal tasks (refer to meta-analysis by Levy and Wagner (2011), Apšvalka et al (2022)).…”

Section: Discussionmentioning

confidence: 87%

“…and regulatory goals (up-or downregulation; Ochsner et al, 2012;Kohn et al, 2014;Morawetz et al, 2017). Previous studies in our laboratory by transcranial magnetic stimulation (TMS) have further demonstrated that the VLPFC is an essential brain region in reappraisal (He et al, 2020b;Li et al, 2022).…”

Section: Introductionmentioning

confidence: 97%

Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study

Cheng

Li²,

Mo³

et al. 2022

Front. Hum. Neurosci.

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The ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in cognitive reappraisal. Previous studies suggested a functional asymmetry of the bilateral VLPFC, but the evidence is still insufficient during cognitive reappraisal. In this study, we conducted an online single-pulse transcranial magnetic stimulation (spTMS) to investigate the causal and distinct roles of the left and right VLPFC in reappraisal. Participants were instructed to reappraise (down-regulate) or attend to pictures depicting social exclusion scenarios while the spTMS was applied over the left or right VLPFC of the participants’ brains. The results showed that spTMS of either the left or the right VLPFC would increase reappraisal difficulty. Meanwhile, the outcome of reappraisal (measured by self-reported negative feelings) significantly deteriorated when the right (but not the left) VLPFC was temporally interrupted by spTMS, while the verbal fluency during oral reporting of the reappraisal strategy was significantly reduced when the left VLPFC was interrupted by spTMS. Taken together, these findings provide causal evidence for the involvement of left and right VLPFC with distinct roles: while the left VLPFC is responsible for the linguistic especially semantic process of generating and selecting appraisals according to the goal of emotion regulation, the right VLPFC plays a critical role in inhibiting inappropriate negative emotions and thoughts generated by the effective scenarios. These findings deepen our understanding of the neurocognitive mechanism of emotion regulation.

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“…Location of the coil was based on the International 10/20 electroencephalogram system. The rVLPFC is at the F8 and the vertex is at the Cz (Li et al, 2022; Zhao et al, 2021). The resting motor threshold (rMT) of each participant was measured in the motor cortex (the C3) and the threshold was defined as 50% of the pulses that reliably produced thumb twitch.…”

Section: Methodsmentioning

confidence: 99%

“…To fill this gap, our lab implemented a series of studies that used an explicit cognitive reappraisal task to explore the role of the rVLPFC on voluntary down‐regulation of social pain. These studies supposed to facilitate the rVLPFC by using the anodal tDCS (He et al, 2018; He, Liu, et al, 2020) or high‐frequency repetitive transcranial magnetic stimulation (rTMS) (He, Zhao, et al, 2020; Li et al, 2022; Zhao et al, 2021), which found that the participants in active tDCS/rTMS group performed better in reappraising social pain compared with the sham tDCS/rTMS group.…”

Section: Introductionmentioning

confidence: 99%

The role of ventrolateral prefrontal cortex on voluntary emotion regulation of social pain

Cao

et al. 2023

Human Brain Mapping

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The right ventrolateral prefrontal cortex (rVLPFC) is highly engaged in emotion regulation of social pain. However, there is still lack of both inhibition and excitement evidence to prove the causal relationship between this brain region and voluntary emotion regulation. This study used high‐frequency (10 Hz) and low‐frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) to separately activate or inhibit the rVLPFC in two groups of participants. We recorded participants' emotion ratings as well as their social attitude and prosocial behaviors following emotion regulation. Also, we used eye tracker to record the changes of pupil diameter to measure emotional feelings objectively. A total of 108 healthy participants were randomly assigned to the activated, inhibitory or sham rTMS groups. They were required to accomplish three sequential tasks: the emotion regulation (cognitive reappraisal) task, the favorability rating task, and the donation task. Results show that the rVLPFC‐inhibitory group reported more negative emotions and showed larger pupil diameter while the rVLPFC‐activated group showed less negative emotions and reduced pupil diameter during emotion regulation (both compared with the sham rTMS group). In addition, the activated group gave more positive social evaluation to peers and donated more money to a public welfare activity than the rVLPFC‐inhibitory group, among which the change of social attitude was mediated by regulated emotion. Taken together, these findings reveal that the rVLPFC plays a causal role in voluntary emotion regulation of social pain and can be a potential brain target in treating deficits of emotion regulation in psychiatric disorders.

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The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback

Cited by 27 publications

References 95 publications

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

The Effect of Non-Invasive Brain Stimulation on the Downregulation of Negative Emotions: A Meta-Analysis

Different Roles of the Left and Right Ventrolateral Prefrontal Cortex in Cognitive Reappraisal: An Online Transcranial Magnetic Stimulation Study

The role of ventrolateral prefrontal cortex on voluntary emotion regulation of social pain

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