Abstract:BackgroundAdipokines played an important role in the pathogenesis of rheumatoid arthritis (RA). However, observational studies have indicated an inconsistent association between adipokines (adiponectin, resistin and leptin) and RA. Therefore, we tried to explore the causal effects of genetically predicted adipokines on RA by two-sample Mendelian randomization (MR) study.MethodsSummary statistics of RA were obtained from a genome-wide association study (GWAS) of European descent, including 14,361 RA cases and 4… Show more
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