The Causal Effects of Lipid Profiles on Sleep Apnea

Tang, Hongyi; Zhou, Qing; Fu, Zheng; Wu, Tong; Tang, Yi‐Da; Jiang, Jie

doi:10.3389/fnut.2022.910690

Cited by 9 publications

(9 citation statements)

References 68 publications

(95 reference statements)

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“…In our previous twin study, we detected a heritable relationship between TG levels and sleep parameters (AHI, ODI, TST90%), suggesting a common genetic background [ 155 ]. The genetic link between OSA and TG levels has recently been confirmed in a genome-wide association study [ 156 ]. Most notably, dyslipidaemia and OSA share common genetic loci, such as PPAR-γ [ 157 , 158 ] or APOE polymorphism [ 159 ].…”

Section: Current Knowledge Of the Pathophysiological Lipid Metabolism...mentioning

confidence: 98%

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Mészáros

Bikov

2022

Biomedicines

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Obstructive sleep apnoea (OSA) is associated with cardiovascular and metabolic comorbidities, including hypertension, dyslipidaemia, insulin resistance and atherosclerosis. Strong evidence suggests that OSA is associated with an altered lipid profile including elevated levels of triglyceride-rich lipoproteins and decreased levels of high-density lipoprotein (HDL). Intermittent hypoxia; sleep fragmentation; and consequential surges in the sympathetic activity, enhanced oxidative stress and systemic inflammation are the postulated mechanisms leading to metabolic alterations in OSA. Although the exact mechanisms of OSA-associated dyslipidaemia have not been fully elucidated, three main points have been found to be impaired: activated lipolysis in the adipose tissue, decreased lipid clearance from the circulation and accelerated de novo lipid synthesis. This is further complicated by the oxidisation of atherogenic lipoproteins, adipose tissue dysfunction, hormonal changes, and the reduced function of HDL particles in OSA. In this comprehensive review, we summarise and critically evaluate the current evidence about the possible mechanisms involved in OSA-associated dyslipidaemia.

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Section: Current Knowledge Of the Pathophysiological Lipid Metabolism...mentioning

confidence: 98%

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Mészáros

Bikov

2022

Biomedicines

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“…Therefore, intervention to prevent changes in triglyceride levels may also help to reduce the risk of MAFLD and OSA. 25 …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, intervention to prevent changes in triglyceride levels may also help to reduce the risk of MAFLD and OSA. 25 There are several limitations to this study. First, this study was a cross-sectional and single-center study on an Asian population, which could not demonstrate a direct causal relationship between OSA and MAFLD.…”

mentioning

confidence: 94%

Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study

Huang¹,

Chen²,

Li³

et al. 2023

NSS

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Aim Emerging evidence has revealed that obstructive sleep apnea (OSA) is an independent risk factor for the development of a variety of adverse metabolic disease states. In this study, we evaluated the association between OSA severity and metabolic dysfunction-associated fatty liver disease (MAFLD) among Asian populations. Materials and Methods This was a cross-sectional, single-center study. The study cohort consisted of patients undergoing polysomnography and abdominal ultrasonography. Logistic regression analysis was used to evaluate the independent risk factors of MAFLD in patients with OSA. Results A total of 1065 patients (277 non-MAFLD and 788 MAFLD) were included in the study. The prevalence of MAFLD in non-OSA, mild-moderate OSA, and severe OSA patients was 58.16%, 72.41%, and 78.0%, respectively ( p < 0.001). We identified significant differences in body mass index (BMI), apnea-hypopnea index (AHI), oxygen desaturation index (ODI), and lowest O 2 saturation (LaSO 2 ) between non-MAFLD and MAFLD patients (all p < 0.001). After adjusting for confounding variables, we used multivariate regression analysis to show that BMI, ODI, and triglyceride (TG) levels independently predicted the occurrence of MAFLD (odds ratio [OR] = 1.234, p < 0.001; OR = 1.022, p = 0.013; OR = 1.384, p = 0.001, respectively). Moreover, stratified analysis according to BMI indicated that TG levels were the predominant risk factor for MAFLD in a group of patients with a BMI < 23 kg/m 2 , while BMI, ODI, TG levels, and total cholesterol (TC) were the major risk factors for MAFLD in a group of patients with a BMI ≥ 23 kg/m 2 (all p < 0.05). Conclusion OSA-associated chronic intermittent hypoxia was independently associated with the risk of MAFLD, especially in OSA patients with a BMI ≥ 23 kg/m 2 , suggesting that oxidative stress might play an important role in the pathogenesis of MAFLD in patients with OSA.

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“…Moreover, a twin study analyzed the heritability of the relationship between OSA and hypertriglyceridemia and found that common genetic factors significantly determined the relationship between indices of chronic intermittent hypoxia and serum TG levels [ 38 ]. A genome-wide association study on the United Kingdom Biobank also indicated that genetically increased TG levels have independent causal effects on the risk of sleep apnea without the confounding effects of obesity [ 39 ]. Consistently, our study found similar results that triglyceride and fasting blood glucose were positively associated with the risk of both OSA and pre-OSA, whereas HDL-CH was negatively associated with the risk of both OSA and pre-OSA, further suggesting that regardless of the number of OSA-related symptoms or severity of OSA, glycolipid biomarkers may help determine risk and should be controlled during daily life.…”

Section: Discussionmentioning

confidence: 99%

Association between glycolipids and risk of obstructive sleep apnea: A population-based study

et al. 2023

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BackgroundThis study aimed to investigate the associations between multiple glycolipid biomarkers and the risk of obstructive sleep apnea (OSA).MethodsParticipants (10,286) aged from 35 to 74 years old were included in this cross-sectional study from the baseline survey of the Guangzhou Heart Study. OSA was ascertained using both Berlin Questionnaire and STOP-BANG Questionnaire. Fasting blood samples were collected from each participant; fasting blood glucose (FBG) and serum concentrations of high-density lipoprotein cholesterol (HDL-CH), low-density lipoprotein cholesterol (LDL-CH), total cholesterol (TC), and triglyceride (TG) were determined. Odds ratio (OR) with 95% confidence interval (CI) was calculated using the multivariate logistic regression model after adjustment for covariates.ResultsOf the participants included, 15.56% were categorized into the pre-OSA group, and 8.22% into the OSA group. When comparing the highest with the lowest quartiles, HDL-HC was associated with a 22% (OR: 0.78, 95% CI: 0.65–0.94) and 41% (OR: 0.59, 95% CI: 0.45–0.78) reduced risk of pre-OSA and OSA, triglyceride was associated with a 32% (OR 1.32, 95% CI 1.08–1.60) and a 56% (OR 1.56, 95% CI 1.18–2.07) increased risk of pre-OSA and OSA, and FBG was associated with a 1.37-fold (95% CI 1.13–1.67) risk of pre-OSA and 1.38-fold (95% CI 1.03–1.85) risk of OSA. A significant exposure-response trend was observed for HDL-HC, TG, and FBG with both OSA and Pre-OSA (all p < 0.05). No significant association of LDL-CH and TC with the risk of both pre-OSA and OSA was observed.ConclusionThe findings suggest that serum HDL-CH was inversely associated with OSA risk, while elevated serum TG and FBG could increase the risk of OSA. Healthy glycolipid metabolism warrants more attention in the field of OSA prevention.

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The Causal Effects of Lipid Profiles on Sleep Apnea

Cited by 9 publications

References 68 publications

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia

Association Between Metabolic-Associated Fatty Liver Disease and Obstructive Sleep Apnea: A Cross-Sectional Study

Association between glycolipids and risk of obstructive sleep apnea: A population-based study

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