The “caudate-spindle” IV. A behavioral index of caudate-induced inhibition

Buchwald, N.A.; Wyers, Everett J.; Lauprecht, C.W.; Heuser, G. F.

doi:10.1016/0013-4694(61)90167-5

Cited by 182 publications

(26 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brumer and Bonnet (13) described that the auditory cortical responses caused by click stimuli in the encephale isole cat were inhibited during a difinite type of alertness and were facilitated during the appearance of the slow pattern in the spontaneous electrical activity. The inhibitory and facilitatory mechanism of the reticular formation on the cortical electrical activity was discussed using the recruiting response by King (1) and Domino (2), the somatosensory response in the internal capsule by King et al (3) and the evoked response in the caudate-cortical pathway by Buchwald et al (14)(15)(16)(17). The quantitative studies of pentobarbital sodium and chloralose on the responses recorded from the auditory cortex (5, 6) allowed the assumption that the small doses of these depressants facilitated the transmission of the auditory ascending impulse to the cortex by inhibit ing the reticular formation ("release phenomenon").…”

Section: Methodsmentioning

confidence: 99%

Effects of Central Depressants on the Evoked Potentials in the Inferior Colliculus Caused by Acoustic Stimuli in the Cat

Nakai

Takaori

Shimamoto

1965

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

It has been well-known that the electrical activity of the central nervous system is facilitated by relatively lower doses of central depressants.Many reports were presented to support the facilitatory mechanism in the brain of exprimental animals at lower dose levels of barbiturates : lowering of stimulation threshold for the recruiting response by King (1) and' Domino (2), increase in amplitude of the somatosensory evoked poten tial recorded from the internal capsule by King et al. (3), and increase in amplitude of the evoked potential recorded from the auditory cortex by Pradhan and Galambos (4).Nakai (5) and Nakai and Takaori (6) showed that pentobarbital sodium, chloralose and chlorpromazine increased the magnitude of the cortical potential evoked by click stimuli and accelerated the manifestation of the ensuing rhythmic after-discharges, while urethane and ethyl alcohol even in small doses reduced the amplitude of the evoked potential.The role of the inferior colliculus as a relay nucleus for the auditory pathway was investigated electrophysiologically by Ades and Brookhart (7) and Thurlow et al. (8).However, there is scarcely any systematic study concerning the effects of central depres sants on the evoked potential in the inferior colliculus. It is considered that the effect of central depressants on the collicular acoustic potential may differ from that on the cortical one. The difference may give some clue for the elucidation of the central audi tory mechanism. METHODSAll experiments were performed in a sound-proof room maintained at the tempera ture of 27°C using cats weighing 2.0 to 3.5 kg. Under ether anesthesia the exposed trachea was intubated and the head of animal was fixed on the stereotaxic instru ment of Todai-Noken type.The left occipital skull covering the cerebrum and cerebellum was , removed, and the left tentorium cerebelli was carefully resected. The left inferior colliculus was exposed for insertion of the recording electrode under direct inspection. The cerebral and cerebellar corticies were not removed. Thereafter, the spinal cord was sectioned at the level of C1 (encephale isole preparation) and the animal was maintained by artificial respiration. A monopolar insulated silver electrode, about

show abstract

Section: Methodsmentioning

confidence: 99%

Effects of Central Depressants on the Evoked Potentials in the Inferior Colliculus Caused by Acoustic Stimuli in the Cat

Nakai

Takaori

Shimamoto

1965

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…However, it is not unreasonable to suppose that the retention losses induced by anterior cortical and corpus striatal lesions resulted from disorders in the initiation (Breen & Thompson, 1966;Levine et aI, 1971), programming (Konorski, 1972;Luria, 1966;Penfield, 1954), correction (Bossom, 1965;Luria, 1966;Rosvold, 1968), and/or inhibition (Buchwald, Wyers, Lauprecht, & Heuser, 1961;Konorski, 1972) of response mechanisms.…”

Section: Some Functional Considerationsmentioning

confidence: 99%

The ’manipulative response memory system’in the white rat

Spiliotis

Thompson

1973

Psychobiology

View full text Add to dashboard Cite

Adult ,1Ihino rats. previously trained on a series of three latch box problems, sustained bilateral cortical or subcortical ksions and werc subsequcntly lcsted for retention. Those animals showing defective retention of all three problems sufkred damage to either the sensorimotor cortex. corpus striatum, posterior thalamus, subthalamus, red nucleus, or brainstcm reticular formation. Excellent retention of at least two of the three problems was found in animals suffering cxtcnsive occipital. dngulatc. pyriform. hippocampal, septal, amygdaloid, pretectal, or tectal damage. These fmdings provide additional evidence for a localized cortico-subcortical system mediating learned responses in the rodent.

show abstract

“…In fact. the opposite occurred, and the animals became activated (Buchwald, Wyers, Lauprecht, & Heuser, 1961). When these points are considered in conjunction with the differential caudate inhibitory effects on directed somatic vs nondirected somatic and autonomic components of attack, it appears that the caudate nucleus is generating a different type of inhibitory influence than that produced by the limbic structures.…”

Section: Discussionmentioning

confidence: 98%

“…Only those cats were used in which caudate electrodes produced the "caudate spindle" (Buchwald, Wyers, Lauprecht, & Heuser, 1961) to I-pps trains of 1.0-msec pulses. Preliminary to the study, the cats were trained to make a barpressing response.…”

Section: Methodsmentioning

confidence: 99%

“…Electrical stimulation of the caudate nucleus influenced the arousal level of cats. High-frequency stimulation (over 30 pps) caused behavioral activation, while low-frequency stimulation (0.2-10 pps) induced a state of general inhibition and eventually caused sleep (Buchwald, Wyers, Lauprecht, & Heuser, 1961). Recently, the inhibitory consequences oflow-frequency caudate stimulation have been observed in a variety of instrumental conditioning situations.…”

mentioning

confidence: 99%

See 1 more Smart Citation