The caudal neurosecretory system and its afferent synapses in the goldfish,Carassius auratus: Morphology, immunohistochemistry, and fine structure

Cioni, Carla; Vito, Luana De; Greco, Alessandra; Pepe, A.

doi:10.1002/(sici)1097-4687(199801)235:1<59::aid-jmor5>3.0.co;2-j

Cited by 15 publications

(10 citation statements)

References 39 publications

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“…In agreement with descriptions by other authors for diverse teleosts (Fisher et al 1984;Yamada et al 1986;Cioni et al 1998), we have found that zebrafish secretory neurons are of various sizes, the largest corresponding to Dahlgren's description. Indeed, the large cells are few in number in the zebrafish and the diameter of their perikarya does not exceed 20 μm.…”

Section: Discussionsupporting

confidence: 92%

“…With respect to the ultrastructural data, our observations are in agreement with the general features of the submicroscopical organization of the caudal neurosecretory system as established previously for other species of fresh or seawater teleost fishes (Enami 1959;Bern and Takasugi 1962;Oota 1963;Sano et al 1966;Fridberg and Bern 1968;Vigh-Teichmann and Vigh 1979;Kriebel 1980;Yulis and Lederis 1986;Cioni et al 1996Cioni et al , 1998. Thus, here we merely comment on some peculiarities of the zebrafish.…”

Section: Discussionsupporting

confidence: 92%

“…In the zebrafish urophysis, the diameter of dense-core vesicles (75-180 nm) is the same as that reported by Oota (1963) in the carp; no large vesicles up to 250-300 nm as mentioned by authors working on other fish species (Bern and Takasugi 1962;Fridberg and Bern 1968;VighTeichmann and Vigh 1979;Cioni et al 1998) have been found. The distribution of the size of the dense-core vesicles has led us to propose the existence of two types of axons (types A and B).…”

Section: Discussionsupporting

confidence: 87%

“…The relationship between the secretory axons and the fenestrated capillaries has been well documented by several authors working on various fish species (Vigh 1975;Vigh-Teichmann and Vigh 1979;Kriebel 1980;Cioni et al 1998). The secretion products seem to pass into the capillaries, as proposed in pioneer electron-microscopic studies of neurosecretory product release in other animals and systems (De Robertis 1962;Scharrer 1968).…”

Section: Discussionmentioning

confidence: 82%

“…In planes of section not involving the process, it might be impossible to recognize the secretory nature of this cell. Cioni et al (1998) in their study of Carassius auratus have distinguished four types of synapse on secretory neurons based on morphological criteria. We have not been able to find these in the zebrafish.…”

Section: Discussionmentioning

confidence: 99%

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Caudal neurosecretory system of the zebrafish: ultrastructural organization and immunocytochemical detection of urotensins

Parmentier¹,

Taxi

Balment

et al. 2006

Cell Tissue Res

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The caudal neurosecretory system is described here for the first time in the zebrafish, one of the most important models used to study biological processes. Light- and electron-microscopical approaches have been employed to describe the structural organization of Dahlgren cells and the urophysis, together with the immunohistochemical localization of urotensin I and II (UI and UII) peptides. Two latero-ventral bands of neuronal perikarya in the caudal spinal cord project axons to the urophysis. The largest secretory neurons (approximately 20 microm) are located rostrally. UII-immunoreactive perikarya are much more numerous than those immunoreactive for UI. A few neurons are immunopositive for both peptides. Axons contain 75-nm to 180-nm dense-core vesicles comprising two populations distributed in two axonal types (A and B). Large dense vesicles predominate in type A axons and smaller ones in type B. Immunogold double-labelling has revealed that some fibres contain both UI and UII, sometimes even within the same neurosecretory granule. UII is apparently the major peptide present and predominates in type A axons, with UI predominating in type B. A surprising finding, not previously reported in other fish, is the presence of dense-core vesicles, similar to those in neurons, in astrocytes including their end-feet around capillaries. Secretory type vesicles are also evident in ependymocytes and cerebrospinal-fluid-contacting neurons in the terminal spinal cord. Thus, in addition to the urophysis, this region may possess further secretory systems whose products and associated targets remain to be established. These results provide the basis for further experimental, genetic and developmental studies of the urophysial system in the zebrafish.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Caudal neurosecretory system of the zebrafish: ultrastructural organization and immunocytochemical detection of urotensins

Parmentier¹,

Taxi

Balment

et al. 2006

Cell Tissue Res

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Development of the caudal neurosecretory system of the Nile tilapiaOreochromis niloticus: An immunohistochemical and electron microscopic study

Cioni

Francia

Greco

et al. 2000

Journal of Morphology

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The development of the caudal neurosecretory system (CNSS) of the Nile tilapia, Oreochromis niloticus, has been investigated by means of UI/oCRF (urotensin I/ovine corticotropin-releasing factor) immunohistochemistry and transmission electron microscopy. UI-like immunoreactive perikarya and fibers are first detected in the caudal spinal cord of larval fish about 4 days after hatching (stage 21). In the region of the future urophysis two bundles of strongly immunoreactive neurosecretory fibers are observed. At this stage, neurosecretory axons terminate on the meninx sheath of the spinal cord with immature neurosecretory terminals. The histogenesis of the urophysis begins at stage 24. The future neurohemal organ consists of a small ventral swelling of the spinal cord, which is associated with dilated vessels. At this stage, neurosecretory axons terminate on the basal lamina of the ingrowing blood vessels. Further development occurs by means of progressive branching of vessels and the concomitant increase in the number of neurosecretory terminals. In the caudal spinal cord, immunoreactive neurons also increase in number and progressively differentiate morphologically. Typical features of the mature CNSS are recognizable in 4-month-old juveniles. Data suggest that in tilapia both the synthesis and the release of urophysial hormones begin before morphogenesis of the neurohemal organ takes place.

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Evolution and Physiology of the Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Vertebrates

Lovejoy

Balment

1999

General and Comparative Endocrinology

261

183

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The caudal neurosecretory system and its afferent synapses in the goldfish,Carassius auratus: Morphology, immunohistochemistry, and fine structure

Cited by 15 publications

References 39 publications

Caudal neurosecretory system of the zebrafish: ultrastructural organization and immunocytochemical detection of urotensins

Caudal neurosecretory system of the zebrafish: ultrastructural organization and immunocytochemical detection of urotensins

Development of the caudal neurosecretory system of the Nile tilapiaOreochromis niloticus: An immunohistochemical and electron microscopic study

Evolution and Physiology of the Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Vertebrates

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