The catabolic effect of glucocorticoids on different types of skeletal muscle fibres and its dependence upon muscle activity and interaction with anabolic steroids

Seene, Teet; Viru, Atko

doi:10.1016/0022-4731(82)90190-x

Cited by 82 publications

(50 citation statements)

References 9 publications

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“…Data relating to the effect of physical activity on glucocorticoid-induced myopathy is contradictory: physical activity has been shown either to prevent [4,25], fail to prevent [8] or even enhance [15] the effects of glucocorticoids on muscle contractile component. The effects seem to be related to the type of exercise.…”

Section: Introductionmentioning

confidence: 94%

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Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Ahtikoski

Riso

Koskinen

et al. 2004

Pfl�gers Archiv European Journal of Physiology

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Glucocorticoids have anti-anabolic effects on many tissues and can cause muscle atrophy. However, their effects on type IV collagen gene expression and degradation in skeletal muscle have not been studied previously. Rats were treated daily with dexamethasone or saline. Half the groups of experimental and control animals were also subjected to daily endurance or uphill running exercise to determine the possible preventive effects of exercise. After an experimental period of 3 or 10 days, the extensor digitorum longus, soleus and tibialis anterior muscles were studied. Dexamethasone treatment for 10 days reduced muscle weight and type IV collagen mRNA abundance in all muscles. Gene expression of matrix metalloproteinase-2 (MMP-2) was decreased in fast muscles. However, the effects of this decrease were possibly attenuated by the simultaneous decrease in the activity of tissue inhibitor of metalloproteinases (TIMP-2). The amount of type IV collagen was not changed during dexamethasone treatment or exercise. The regulation of type IV collagen degradation during dexamethasone treatment varied between slow and fast muscles. Although endurance running prevented muscle atrophy, exercise could not compensate the changes observed in the regulation of type IV collagen gene expression and degradation during dexamethasone treatment.

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Section: Introductionmentioning

confidence: 94%

“…Overproduction and overuse of glucocorticoids cause muscle atrophy and loss of muscle function [25], particularly destruction of myofilaments [26]. To date, however, the effects of glucocorticoids on skeletal muscle connective tissue have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Ahtikoski

Riso

Koskinen

et al. 2004

Pfl�gers Archiv European Journal of Physiology

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show abstract

“…The importance of such a contention, as discussed by Laurent and Millward (1980), implicates protein degradation as an event that may inhibit skeletal muscle growth rather than being an integral component of the hypertrophy process. Therefore, reductions in the CORT response and hormone-mediated protein degradation are potential mechanisms by which protein accretion occurs, that of stimulating muscle growth by suppressing muscle breakdown (Goldberg 1969;Seene and Viru 1982).…”

Section: Introductionmentioning

confidence: 99%

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

2006

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This investigation examined chronic alteration of the acute hormonal response associated with liquid carbohydrate (CHO) and/or essential amino acid (EAA) ingestion on hormonal and muscular adaptations following resistance training. Thirty-two untrained young men performed 12 weeks of resistance training twice a week, consuming ~675 ml of either, a 6% CHO solution, 6 g EAA mixture, combined CHO + EAA supplement or placebo (PLA). Blood samples were obtained pre- and post-exercise (week 0, 4, 8, and 12), for determination of glucose, insulin, and cortisol. 3-Methylhistidine excretion and muscle fibre cross-sectional area (fCSA) were determined pre- and post-training. Post-exercise cortisol increased (P<0.05) during each training phase for PLA. No change was displayed by EAA; CHO and CHO + EAA demonstrated post-exercise decreases (P<0.05). All groups displayed reduced pre-exercise cortisol at week 12 compared to week 0 (P<0.05). Post-exercise insulin concentrations showed no change for PLA; increases were observed for the treatment groups (P<0.05), which remained greater for CHO and CHO + EAA (P<0.001) than PLA. EAA and CHO ingestion attenuated 3-methylhistidine excretion 48 h following the exercise bout. CHO + EAA resulted in a 26% decrease (P<0.01), while PLA displayed a 52% increase (P<0.01). fCSA increased across groups for type I, IIa, and IIb fibres (P<0.05), with CHO + EAA displaying the greatest gains in fCSA relative to PLA (P<0.05). These data indicate that CHO + EAA ingestion enhances muscle anabolism following resistance training to a greater extent than either CHO or EAA consumed independently. The synergistic effect of CHO + EAA ingestion maximises the anabolic response presumably by attenuating the post-exercise rise in protein degradation.

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“…Les (Goldstein, 1975). Les GC augmenteraient par contre la concentration des protéases intracellulaires non lysosomales, comme la leucine aminopeptidase (Rose et aL, 1959), ou des protéases myofibrillaires (Mayer et Rosen, 1976) actives à pH neutre ou alcalin (Seene et Viru, 1982).…”

Section: Insulineunclassified

“…Le taux de synthèse de l'actine et des chaînes lourdes de la myosine diminue dans tous les types de fibres mais seulement dans les fibres lentes oxydatives dans le cas des chaînes légères de la myosine. En fait, la réduction de poids des diffé-rents types de muscles chez des animaux traités à la dexaméthasone correspond totalement à l'augmentation de l'activité des protéases myofibrillaires (Seene et Viru, 1982 (Tomas et al, 1970 Goldspink, 1979).…”

Section: Insulineunclassified

Propriétés des fibres musculaires squelettiques. II. Influences hormonales

Vigneron¹,

Dainat²,

Bacou³

1989

Reprod. Nutr. Dévelop.

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The catabolic effect of glucocorticoids on different types of skeletal muscle fibres and its dependence upon muscle activity and interaction with anabolic steroids

Cited by 82 publications

References 9 publications

Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

Propriétés des fibres musculaires squelettiques. II. Influences hormonales

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