The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway

Chen, Wenjuan; Chen, Yanjie; Qian, Yun; Zhang, Jun; Hu, Xiaoshan; Yan, Xiangyun; Jiang, Chengyao; Yao, Shuwen; Yu, Qinlei; Chen, Xiaohui; Han, Song

doi:10.1039/d2fo02400d

Food Funct.

2023

DOI: 10.1039/d2fo02400d

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The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway

Wenjuan Chen

Yanjie Chen

Yun Qian

et al.

Abstract: The effect of peptides in NEC remains poorly understood. Our study showed that YFYPEL reduced inflammation and enhanced migration by regulating the PI3K/AKT pathway. The peptide may thus develop into a novel modality in NEC treatment.

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2024

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Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

Bu,

Hu,

et al. 2024

J Cellular Molecular Medi

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Intestinal dysbiosis is believed to play a role in the development of necrotizing enterocolitis (NEC). The efficacy of JNK‐inhibitory peptide (CPJIP) in treating NEC was assessed. Treatment with CPJIP led to a notable reduction in p‐JNK expression in IEC‐6 cells and NEC mice. Following LPS stimulation, the expression of RNA and protein of claudin‐1, claudin‐3, claudin‐4 and occludin was significantly decreased, with this decrease being reversed by CPJIP administration, except for claudin‐3, which remained consistent in NEC mice. Moreover, the expression levels of the inflammatory factors TNF‐α, IL‐1β and IL‐6 were markedly elevated, a phenomenon that was effectively mitigated by the addition of CPJIP in both IEC‐6 cells and NEC mice. CPJIP administration resulted in improved survival rates, ameliorated microscopic intestinal mucosal injury, and increased the total length of the intestines and colon in NEC mice. Additionally, CPJIP treatment led to a reduction in serum concentrations of FD‐4, D‐lactate and DAO. Furthermore, our results revealed that CPJIP effectively inhibited intestinal cell apoptosis and promoted cell proliferation in the intestine. This study represents the first documentation of CPJIP's ability to enhance the expression of tight junction components, suppress inflammatory responses, and rescue intestinal cell fate by inhibiting JNK activation, ultimately mitigating intestinal severity. These findings suggest that CPJIP has the potential to serve as a promising candidate for the treatment of NEC.

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Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

Bu,

Hu,

et al. 2024

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

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The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway

Abstract: The effect of peptides in NEC remains poorly understood. Our study showed that YFYPEL reduced inflammation and enhanced migration by regulating the PI3K/AKT pathway. The peptide may thus develop into a novel modality in NEC treatment.

Cited by 1 publication

References 33 publications

Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

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