The Case of an Asymptomatic Pheochromocytoma Masquerading as a Pancreatic Neuroendocrine Tumor

Baumrucker, Camille; Kalavar, Meghana; Barkin, Jodie A.; Franceschi, Dido

doi:10.1097/mpa.0000000000001618

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…This can be further complicated by the fact that around 10% of pancreatic neuroendocrine tumors are associated with hereditary syndromes like multiple endocrine neoplasia type I (MEN1), von Hippel-Lindau syndrome, neurofibromatosis type 1, and tuberous sclerosis complex (TSC). Preoperative diagnosis can be done through fine-needle aspiration and biopsy, but PGLs and PANNET can have similar morphologic characteristics, leading to misdiagnosis (5)(6)(7)(8). Accurate diagnosis is crucial for proper pre-and post-treatment decision-making (9).…”

Section: Introductionmentioning

confidence: 99%

Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors

et al. 2023

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IntroductionParagangliomas (PGL), a type of neuroendocrine tumor, pose a significant diagnostic challenge due to their potential for unpredictable locations and asymptomatic presentation. Misdiagnosis of peripancreatic PGLs, particularly as pancreatic neuroendocrine tumors (PANNETs), is a pressing issue as it can negatively impact both pre- and post-treatment decision-making. The aim of our study was to identify microRNA markers for the reliable differential diagnosis of peripancreatic PGLs and PANNETs, addressing a crucial unmet need in the field and advancing the standard of care for these patients.MethodsMorphing projections tool was used to analyze miRNA data from PGL and PANNET tumors present in the TCGA database. The findings were validated using two additional databases: GSE29742 and GSE73367.ResultsOur research uncovered substantial differences in the miRNA expression profiles of PGL and PANNET, leading to the identification of 6 key miRNAs (miR-10b-3p, miR-10b-5p, and the miRNA families miR-200c/141 and miR-194/192) that can effectively differentiate between the two types of tumors.DiscussionThese miRNA levels hold potential as biomarkers for improved diagnosis, offering a solution to the diagnostic challenge posed by these tumors and potentially improving the standard of care for patients.

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Section: Introductionmentioning

confidence: 99%

Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors

et al. 2023

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Adrenal pheochromocytoma masquerading as a hydatid cyst: A case report and review of literature

Saxena,

Roy,

Gaurav

et al. 2024

Journal of Minimal Access Surgery

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Hydatid cysts, caused by Echinococcus larval infections, are common in certain regions. In an unusual medical case, a 26-year-old female with a hydatid cyst was unexpectedly found to have an adrenal pheochromocytoma, a rare tumour producing catecholamines. She initially complained of persistent, non-specific right upper abdominal pain. Imaging revealed a cystic lesion resembling a hydatid cyst. During surgery, unexpected arrhythmia and electrocardiographic changes led to the suspicion of acute coronary syndrome, halting the procedure. Further investigation revealed elevated urinary metanephrine levels and a suspicious soft-tissue mass, resulting in laparoscopic right adrenalectomy with hypertensive spikes. The patient was successfully managed, and post-operative examination confirmed the adrenal pheochromocytoma. Hydatid cysts usually present with non-specific symptoms and are diagnosed through imaging. Similarly, diagnosing cystic pheochromocytomas is challenging without typical symptoms, potentially leading to intraoperative complications. Misdiagnosed cases can result in hypertensive crises and hypotension, requiring specific management. Due to their variable presentation and rarity, pheochromocytomas are often misdiagnosed.

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The Case of an Asymptomatic Pheochromocytoma Masquerading as a Pancreatic Neuroendocrine Tumor

Cited by 2 publications

References 6 publications

Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors

Visual analytics identifies key miRNAs for differentiating peripancreatic paraganglioma and pancreatic neuroendocrine tumors

Adrenal pheochromocytoma masquerading as a hydatid cyst: A case report and review of literature

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