The case for a ketogenic diet in the management of kidney disease

Athinarayanan, Shaminie J; Roberts, Caroline G P; Vangala, Chandan; Shetty, Greeshma K; McKenzie, Amy L; Weimbs, Thomas; Volek, Jeff S

doi:10.1136/bmjdrc-2024-004101

Cited by 4 publications

(1 citation statement)

References 134 publications

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“…Это вызывает образование кетонов, которые используются в качестве альтернативного топлива для клеток, способствуя снижению аппетита, уровня инсулина и улучшению тканевой чувствительности к инсулину [13]. Низкоуглеводные диеты могут повышать уровень МК из-за увеличенного употребления пуринов, содержащихся в белковых продуктах, и конкуренции кетонов с МК за их выведение почками, что усиливает риск обострений подагры [14]. В то же время такие диеты позволяют добиться снижения веса, коррекции метаболических нарушений в рамках метаболического синдрома (МС), возможны также противовоспалительные эффекты и модификация окислительного стресса.…”

Section: низкоуглеводные диетыunclassified

Battle of the strategies: diet versus drug therapy for gout

Zhelyabina,

Eliseev,

Lila

2024

Sovremennaâ revmatologiâ

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The best results in combating gout are achieved through a combination of diet and drug therapy. Urate-lowering therapy, which includes febuxostat, has been shown to be more effective and convenient than diet when it comes to achieving and maintaining target uric acid (UA) levels in gout patients. Febuxostat, a xanthine oxidase inhibitor, helps to reduce UA levels in the blood by blocking its formation. This helps prevent the deposition of urate crystals in joints and tissues and reduces the frequency and severity of gout attacks. At the same time, a diet of low purine foods may also have some effect on UA levels. Diet can improve the results of drug treatment by reducing the need for medications and minimizing the risk of side effects. However, without adequate drug therapy, diet will not produce the desired results. Therefore, febuxostat remains the preferred urate-lowering treatment option for gout, especially given its proven efficacy in these patients.

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Section: низкоуглеводные диетыunclassified

Battle of the strategies: diet versus drug therapy for gout

Zhelyabina,

Eliseev,

Lila

2024

Sovremennaâ revmatologiâ

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Diabetic Kidney Disease: Contribution of Phenyl Sulfate Derived from Dietary Tyrosine upon Gut Microbiota Catabolism

Liu,

Diep,

Wang

et al. 2024

Biomolecules

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Deranged gut microbiota can release increased levels of uremic toxins leading to exacerbated kidney injury. In diabetic kidney disease (DKD), phenyl sulfate (PS) derived from tyrosine catabolism by gut microbiota has been demonstrated to be both an early diagnostic marker and a therapeutic target. In this perspective article, we summarize PS generation pathways and recent findings on PS and kidney injury in DKD. Increasing evidence has shown that the underlying mechanisms of PS-induced kidney injury mainly involve oxidative stress, redox imbalance, and mitochondrial dysfunction, which all may be targeted to attenuate PS-induced kidney injury. For future research directions, we think that a deeper understanding of the pathogenic role of PS in kidney injury using a variety of diabetic animal models should be investigated. Moreover, we also suggest beneficial approaches that could be used to mitigate the deleterious effect of PS on the kidney. These approaches include caloric restriction, tyrosine restriction, and administration of ketogenic drugs, ketogenic diets or natural products; all of which should be conducted under obese and diabetic conditions.

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Replacement of Dietary Carbohydrate with Protein versus Fat Differentially Alters Postprandial Circulating Hormones and Macronutrient Metabolism in Dogs

Jackson

2024

Metabolites

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The effect of dietary macronutrients on fasting and postprandial responses was examined. Thirty-six healthy dogs were fed a high-carbohydrate (HiCHO) food once daily for 5 weeks, followed by randomization to either a high-protein, low-carbohydrate (PROT_LoCHO) or high-fat, low-carbohydrate (FAT_LoCHO) food for 5 weeks, then crossed over to the other LoCHO food for 5 weeks. Plasma samples were obtained at the end of each feeding period at timepoints before (0 h) and 2 h post-feeding. Apparent total circulating energy availability was assessed as a summation of the energetic contributions of measured glucose, β-hydroxybutyrate, triglycerides (TGs), non-esterified fatty acids (NEFAs), and fatty acids not from TGs or NEFAs. In both the fed and fasted states, there were increases in circulating apparent total energy availability after feeding the FAT_LoCHO food compared with the HiCHO or PROT_LoCHO foods. Changes from the postabsorptive to postprandial points in catabolic, anabolic, and signaling lipids all exhibited food effects. Consumption of either LoCHO food led to lower leptin/ghrelin ratios in the fasted state relative to the HiCHO food. The FAT_LoCHO food led to the highest postprandial levels of the incretins gastric inhibitory peptide and glucagon-like peptide-1, yet the lowest increases in insulin relative to the other foods. These findings provide information on how macronutrients can influence dietary energy processing and metabolic health.

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The case for a ketogenic diet in the management of kidney disease

Cited by 4 publications

References 134 publications

Battle of the strategies: diet versus drug therapy for gout

Battle of the strategies: diet versus drug therapy for gout

Diabetic Kidney Disease: Contribution of Phenyl Sulfate Derived from Dietary Tyrosine upon Gut Microbiota Catabolism

Replacement of Dietary Carbohydrate with Protein versus Fat Differentially Alters Postprandial Circulating Hormones and Macronutrient Metabolism in Dogs

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