The carriage of Staphylococcus (ptogenes) aureus in man and its relation to wound infection

Miles, A. A.; Williams, R. E. O.; Clayton-Cooper, Barbara

doi:10.1002/path.1700560405

Cited by 117 publications

(39 citation statements)

References 10 publications

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“…Several studies have shown that patients may riers of coagulase-po)sitive staphylococci (15,16 Patients with diabetes or debilitating diseases also have a higher incidence of staphylococcal infections (17). The large numbers of nasal staphylococci in patients with these diseases may be a reflection of a generalized increased susceptibility to infections due to unknown causes.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Studies of Nasal Carriers of Staphylococci Among Hospitalized Patients*

White¹

1961

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Quantitative Studies of Nasal Carriers of Staphylococci Among Hospitalized Patients*

White¹

1961

J. Clin. Invest.

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“…From the nose the organism is passed to other sites on the body surface, to the clothes and thence to dust particles. The nasal carrier rate has been determined by many investigators and, based on a single examination, averages about 85 % for infants (Miles, 1941;McFarlan, 1942;Martyn, 1949;Thomas & Cunliffe, 1949;Duncan & Walker, 1949;Ludlam, 1953), 57 % for children (Hallman, 1937;McFarlan, 1938;Miles, 1941;Cunliffe, 1949), 45 % for adolescents and young adults (Hailman, 1937;McFarlan, 1938;Gillespie, Devenish & Cowan, 1939;Miles, Williams & Clayton-Cooper, 1944;Rountree, Barbour & Thomson, 1951), 50 % for adults (Hallman, 1937;McFarlan, 1938;Miles et al 1944;Williams, 1946;Thomas & Cunliffe, 1949;Rountree & Thomson, 1949;Elwood, 1951) and 65 % for hospital staff (Hart, 1937;Devenish & Miles, 1939;Allison & Hobbs, 1947;Barber & Rozwadowska-Dowzenko, 1949;Rountree & Thomson, 1949;Rountree, Barbour & Thomson, 1951;Martin & Whitehead, 1949). Repeated examination of the same individuals has shown that the presence of staphylococci is sporadic in some and constant in others (Williams, 1946).…”

Section: Introductionmentioning

confidence: 99%

The carriage of Staphylococcus pyogenes var. aureus in the human nose

Gould

McKillop

1954

J. Hyg.

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Over 500 medical students have been examined for nasal carriage of Staph. pyogenes at weekly intervals over a period ranging from 3 to 12 months.Nasal carriers were classified as persistent, intermittent and occasional. Of the students, 39% were persistent or intermittent carriers in whom the staphylococcus was believed to colonize the skin of the vestibule of the nose; 42% were occasional carriers in whom the staphylococcus was only a chance inhabitant of the nares.Staph. pyogenes was isolated from the anterior nares of persistent carriers on at least 90% of the occasions on which they were examined, and was of the same phage type on each occasion. From intermittent carriers it was isolated less regularly, but on at least 10% of occasions on which they were examined, and it remained of one phage type. Staph. pyogenes was isolated at less than 10% of swabbings from occasional carriers, and at each the organism was of a different phage type.Eighty-nine per cent of persistent and intermittent carrier strains, and 54% of occasional carrier strains could be typed with phage filtrates. The strains not typable with phage filtrates, and found predominantly among occasional carriers, were considered worthy of separate classification, and it is suggested that typability with phage be used as a criterion of pathogenicity for Staph. pyogenes.We wish to thank Prof. T. J. Mackie for his continued interest and advice; Dr J. P. Duguid for criticism and advice; Dr R. E. O. Williams and Miss Joan Rippon of the Staphylococcal Reference Laboratory, Colindale, who very kindly instructed one of us (J.C.G.) in bacteriophage typing; Dr Donald Cruickshank for taking nasal swabs from patients; Dr Cumming of the Blood Transfusion Department, Royal Infirmary, Edinburgh, for permission to swab blood donors, and the medical students who so willingly co-operated in this work.

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“…Of the 166 hemolytic strains, 16 did not exhibit classical alpha or alphabeta types of hemolysis. Instead they were surrounded by small hazy zones of incomplete hemolysis.…”

Section: The Coagulase Testmentioning

confidence: 99%

Studies on the Incidence of Coagulase-Positive Staphylococci in a Normal Unconfined Population

Millian¹,

Baldwin²,

Rheins³

et al. 1960

Am J Public Health Nations Health

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The carriage of Staphylococcus (ptogenes) aureus in man and its relation to wound infection

Cited by 117 publications

References 10 publications

Quantitative Studies of Nasal Carriers of Staphylococci Among Hospitalized Patients*

Quantitative Studies of Nasal Carriers of Staphylococci Among Hospitalized Patients*

The carriage of Staphylococcus pyogenes var. aureus in the human nose

Studies on the Incidence of Coagulase-Positive Staphylococci in a Normal Unconfined Population

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