The CAREGENE study: polymorphisms of the β1-adrenoceptor gene and aerobic power in coronary artery disease

Defoor, Johan; Martens, Kevin; Zielińska, Dominika; Matthijs, Gert; Nerum, Hilde Van; Schepers, Dirk; Fagard, Robert; Vanhees, Luc

doi:10.1093/eurheartj/ehi737

Cited by 49 publications

(40 citation statements)

References 44 publications

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“…Stroke subtypes were determined using the TOAST criteria by a single stroke neurologist who was blinded to genotype. Patients with CHD (n = 926) were recruited from the CAREGENE study [17]. Control individuals (n = 1359) from the same population were recruited for the BSS as described [15] and amongst healthy individuals, spouses of patients suffering from neurological diseases (amyotrophic lateral sclerosis, ischemic stroke or multiple sclerosis), patients with amyotrophic lateral sclerosis and from the Leuven University Gerontology Database [18].…”

Section: R L E M M E N S * à S a B B O U D § L V A N H E E mentioning

confidence: 99%

Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease

Lemmens

Abboud

Vanhees

et al. 2008

Journal of Thrombosis and Haemostasis

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Section: R L E M M E N S * à S a B B O U D § L V A N H E E mentioning

confidence: 99%

Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease

Lemmens

Abboud

Vanhees

et al. 2008

Journal of Thrombosis and Haemostasis

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“…In the CAREGENE study in patients with coronary artery disease, resting diastolic blood pressure was significantly lower in patients homozygous for Gly389 than in those with Arg389 allele [28]. However, in the patients with essential hypertension, there are no differences in resting blood pressure among Arg389Gly genotypes [29][30][31][32].…”

Section: Polymorphisms Of Adrenoreceptor and Risk For Hypertensionmentioning

confidence: 94%

Pharmacogenomics of Adrenergic Receptors; from Hypertension to Heart Failure

Nonen¹,

Azuma²,

Fujio³

2010

TOHYPERJ

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Cardiovascular medicine is a leading area of pharmacogenomics (PGx). A number of PGx studies have linked genetic polymorphisms to patients' response to the drugs in the pharmacotherapy against cardiovascular diseases. Among them, PGx of adrenoceptors is one of the most important fields, because adrenergic networks play important roles in cardiovascular systems. The excess of adrenergic stimuli result in cardiovascular disorders, such as hypertension and heart failure (HF). One of the aims of PGx studies of adrenoreceptors is the personalization of β-blocker therapy. In this review, we have described biological and clinical impacts on genetic variants of adrenoreceptors, some of which have showed clear association with the reduction in heart rate and blood pressure in response to β-blockers. Beyond anti-hypertension therapy, PGx of adrenoreceptors would contribute to the individualization of pharmacotherapy against HF.

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“…The majority (~90%) of them lived most of their lives and were born in the same area of Spain (Meseta Castellana,~600 m altitude). (Zintzaras et al 2008;Sancho et al 1976), ischemic stroke (Slowik et al 2007) type II diabetes (Zhou et al 2009 Cardiorespiratory fitness in CAD (Defoor et al 2006;Wagoner et al 2002) 0 = GG, 1 = CG, 2 = CC ADRB2 Adrenergic, beta-2-, receptor…”

Section: Methodsmentioning

confidence: 99%

Are centenarians genetically predisposed to lower disease risk?

Ruiz

Fiuza‐Luces

Buxens³

et al. 2011

AGE

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Our study purpose was to compare a disease-related polygenic profile that combined a total of 62 genetic variants among (i) people reaching exceptional longevity, i.e., centenarians (n=54, 100-108 years, 48 women) and (ii) ethnically matched healthy controls (n=87, 19-43 years, 47 women). We computed a 'global' genotype score (GS) for 62 genetic variants (mutations/polymorphisms) related to cardiometabolic diseases, cancer or exceptional longevity, and also specific GS for main disease categories (cardiometabolic risk and cancer risk, including 36 and 24 genetic variations, respectively) and for exceptional longevity (7 genetic variants). The 'global' GS was similar among groups (centenarians: 31.0±0.6; controls 32.0±0.5, P=0.263). We observed that the GS for hypertension, cancer (global risk), and other types of cancer was lower in the centenarians group compared with the control group (all P<0.05), yet the difference became non significant after adjusting for sex. We observed significant between-group AGE (2012) 810-13.839), whereas the likelihood of having the GSTMI low-risk (functional) allele was similar in both groups (OR 1.295; 95% CI, 0.868 -1.931). In conclusion, we found preliminary evidence that Spanish centenarians have a lower genetic predisposition for cancer risk. The wild-type (i.e., functional) genotype of GSTT1, which is associated with lower cancer risk, might be associated with exceptional longevity, yet further studies with larger sample sizes must confirm these findings.

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The CAREGENE study: polymorphisms of the β1-adrenoceptor gene and aerobic power in coronary artery disease

Abstract: Ser49Gly and haplotype combinations of Ser49Gly and Gly389Arg of the beta(1)AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.

Cited by 49 publications

References 44 publications

Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease

Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease

Pharmacogenomics of Adrenergic Receptors; from Hypertension to Heart Failure

Are centenarians genetically predisposed to lower disease risk?

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