The Cardiovascular Toxicity of Amitryptyline

Cobbin, L. B.; Dhumma-Upakorn, Prasan

doi:10.1016/b978-0-08-021308-8.51227-8

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“…A cardiotonic substance was extracted from the spleen by Cobbin and Thorp (2). Lee and Thorp (10) found that this spleen extract inhibited the uptake of calcium by cardiac sarcoplasmic reticulum prepared from dog hearts, as does digitalis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs

Liang¹,

Volicer²

1975

Pharmacology

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Epinephrine infusion, 5-percent oxygen breathing, and splenic nerve stimulation were employed to increase cardiac output by 50–100 % in anesthetized dogs. Epinephrine infusion, as expected, increased plasma and myocardial cyclic AMP concentrations. Arterial hypoxemia increased cyclic AMP concentration in plasma but not in the heart. Practolol pretreatment abolished the increase in plasma cyclic AMP concentration and reduced the rise in cardiac output during hypoxemia. Splenic nerve stimulation was not associated with increases in either plasma or myocardial cyclic AMP. Adenylate cyclase activity was increased by addition of plasma into the incubation medium. However, splenic venous plasma obtained during splenic nerve stimulation did not increase adenylate cyclase activity more than control plasma obtained before stimulation. We conclude that the positive inotropic action of arterial hypoxemia and splenic nerve stimulation does not depend on the adenylate cyclase-cyclic AMP system.

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Section: Discussionmentioning

confidence: 99%

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs

Liang¹,

Volicer²

1975

Pharmacology

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The Cardiovascular Toxicity of Amitryptyline

Cited by 1 publication

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Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs

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The Cardiovascular Toxicity of Amitryptyline

Cited by 1 publication

References 0 publications

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5&rsquo;-Monophosphate in Dogs

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5&rsquo;-Monophosphate in Dogs

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Product

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About

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs

Effects of Arterial Hypoxemia and Splenic Nerve Stimulation on Myocardial Adenosine 3,5’-Monophosphate in Dogs