The cardiovascular risk factor profile in the study area Augsburg. Results from the first MONICA survey 1984/85

Keil, Ulrich; Stieber, Jutta; Döring, Angela; Chambless, Lloyd E.; Härtel, Ursula; Filipiak, Birgit; Hense, Hans Werner; Tietze, M.; Gostomzyk, J. G.

doi:10.1111/j.0954-6820.1988.tb05563.x

Cited by 128 publications

(49 citation statements)

References 3 publications

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“…Nonfasting blood samples were collected from all subjects under standardized conditions in 1989/1990 [23]. Total cholesterol was measured by an enzymatic method (CHOD-PAP, Boehringer Mannheim, Mannheim, Germany) and high-density lipoprotein (HDL) cholesterol was measured after precipitation with phosphotungstic acid/Mg2+ (Boehringer Mannheim, Mannheim, Germany) on fresh samples.…”

Section: Covariablesmentioning

confidence: 99%

Association between domains of physical activity and all-cause, cardiovascular and cancer mortality

et al. 2010

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International audienceFew studies have investigated the independent effects of domain-specific physical activity on mortality. We sought to investigate the association of physical activity performed in different domains of daily living on all-cause, cardiovascular (CVD) and cancer mortality. Using a prospective cohort design, 4,672 men and women, aged 25-74 years, who participated in the baseline examination of the MONICA/KORA Augsburg Survey 1989/1990 were classified according to their activity level (no, light, moderate, vigorous). Domains of self-reported physical activity (work, transportation, household, leisure time) and total activity were assessed by the validated MOSPA (MONICA Optional Study on Physical Activity) questionnaire. After a median follow-up of 17.8 years, a total of 995 deaths occurred, with 452 from CVD and 326 from cancer. For all-cause mortality, hazard ratios and 95% confidence interval (HR, 95% CI) of the highly active versus the inactive reference group were 0.69 (0.48-1.00) for work, 0.48 (0.36-0.65) for leisure time, and 0.73 (0.59-0.90) for total activity after multivariable adjustments. Reduced risks of CVD mortality were observed for high levels of work (0.54, 0.31-0.93), household (0.80, 0.54-1.19), leisure time (0.50, 0.31-0.79) and total activity (0.75, 0.55-1.03). Leisure time (0.36, 0.23-0.59) and total activity (0.62, 0.43-0.88) were associated with reduced risks of cancer mortality. Light household activity was related to lower all-cause (0.82, 0.71-0.95) and CVD (0.72, 0.58-0.89) mortality. No clear effects were found for transportation activities. Our findings suggest that work, household, leisure time and total physical activity, but not transportation activity, may protect from premature mortality

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Section: Covariablesmentioning

confidence: 99%

Association between domains of physical activity and all-cause, cardiovascular and cancer mortality

et al. 2010

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“…In brief, from the entire study population of 212,157 inhabitants living in the area, a sample was selected from the population registration offices, where all German inhabitants are registered. A two-stage cluster sampling method was adopted from the World Health Organization (WHO) Monitoring Cardiovascular Disease Project in Augsburg, Germany [8]. A representative sample was drawn, comprising 7,008 adults aged 20-79 yrs with 292 persons of each sex in each of the twelve 5-yr age strata.…”

Section: Study Populationmentioning

confidence: 99%

Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study

Koch¹,

Schäper²,

Ittermann³

et al. 2008

European Respiratory Journal

177

168

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Cardiopulmonary exercise testing (CPET) is a widely applied clinical procedure. The aim of the present study was to acquire a comprehensive set of reference values for cardiopulmonary responses to exercise and to evaluate possible associations with sex, age and body mass index (BMI).A standardised progressive incremental exercise protocol on a cycle ergometer was applied to 1,708 volunteers of a cross-sectional epidemiologic survey, called ''Study of Health in Pomerania''. Individuals with cardiopulmonary disorders, or echocardiographic or lung function pathologies, were excluded. The influence of potential confounding factors, such as smoking, taking b-blockers, hypertension, diastolic dysfunction, BMI and physical activity, were analysed for their influencing power. Reference values of CPET parameters were determined by regression analyses.Of the volunteers, 542 current smokers and obese individuals were excluded for not being representative of a healthy population. The final sample size was 534 (253 males), with age 25-80 yrs. The current study provides a representative set of reference values for CPET parameters based on age and weight.Sex and age have a significant influence on exercise parameters. While addressing the problem of a selection bias, the current study provides the first comprehensive set of reference values obtained in a large number of healthy volunteers within a population-based survey.KEYWORDS: Cardiopulmonary exercise testing, oxygen uptake, reference values, Study of Health in Pomerania, ventilatory efficiency C ardiopulmonary exercise testing (CPET) is a widely applied routine procedure in daily clinical work, used for the investigation of cardiac and pulmonary disorders. Due to their prognostic and therapeutic implications [1,2], the normalcy of response to incremental exercise is usually considered with respect to particular functional indices, such as the peak oxygen uptake (V9O 2 ,peak), the estimated lactate threshold (hL) and the characterisation of ventilatory efficiency expressed by the minute ventilation (V9E) changes as a function of the pulmonary carbon dioxide output (V9E-V9CO 2 slope). Reference values for these indices have been established, usually with respect to sex, age, body features and physical activity, by several investigators [3][4][5]. The interpretation of the results of exercise tests requires knowledge of the normal response [6], but a consensus has not been reached on the definition of normalcy. The commonly used reference values are based on exercise capacities of shipyard workers [3] or university members [4]. ''Healthy volunteers'' were usually defined as subjects without self-reported evidence or clinical symptoms and signs of heart and lung disease, a normal resting electrocardiogram (ECG), a normal 12-lead ECG response to an exercise stress test and the absence of any medication, especially any with cardiorespiratory effects. However, obtainable reference data sets show relevant limitations, considering their sample recruitment, age distributi...

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“…SHIP is a population-based project in the northeast of Germany. Study details are given elsewhere [19][20][21]. In brief, from the entire study population of 212,157 inhabitants living in the area, a sample was selected from the population registration offices, where all German inhabitants are registered.…”

Section: Study Populationmentioning

confidence: 99%

“…In brief, from the entire study population of 212,157 inhabitants living in the area, a sample was selected from the population registration offices, where all German inhabitants are registered. A two-stage cluster sampling method was adopted from the WHO MONICA Project Augsburg, Germany [20]. A representative sample was drawn, comprised of 7008 adults, ages 20 to 79 years with 292 persons of each gender in each of the twelve 5-year age strata.…”

Section: Study Populationmentioning

confidence: 99%

Association of circulating IGF-I and IGFBP-3 concentrations and exercise capacity in healthy volunteers: Results of the Study of Health in Pomerania

Gläser

Friedrich

Ewert

et al. 2010

Growth Hormone & IGF Research

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The cardiovascular risk factor profile in the study area Augsburg. Results from the first MONICA survey 1984/85

Cited by 128 publications

References 3 publications

Association between domains of physical activity and all-cause, cardiovascular and cancer mortality

Association between domains of physical activity and all-cause, cardiovascular and cancer mortality

Reference values for cardiopulmonary exercise testing in healthy volunteers: the SHIP study

Association of circulating IGF-I and IGFBP-3 concentrations and exercise capacity in healthy volunteers: Results of the Study of Health in Pomerania

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