The Cardiovascular Response of Normal Anaesthetized Man to Rapid Infusion of Saline

Askrog, V; Orkin, Louis R.

doi:10.1097/00132586-196708000-00024

Cited by 2 publications

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“…Previous studies have suggested that the increase in pulmonary artery pressure after rapid infusions of crystalloid may be quite transient, with modest increases in pulmonary pressures returning to baseline values within 15-20 min. 20 Measurement of central venous or pulmonary artery pressures would help further to define the degree of fluid redistribution. Colloidal solutions may be more effective in attenuating the decrease in blood pressure because a greater proportion is retained in the intravascular space.…”

Section: Discussionmentioning

confidence: 99%

Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl

Turner¹,

Gatt²,

Kam³

et al. 1998

British Journal of Anaesthesia

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Anaesthesia was induced in 58 women (ASA I or II) undergoing elective gynaecological procedures, using propofol 2.5 mg kg-1 and fentanyl 1.5 micrograms kg-1. Patients were allocated to receive 20 ml kg-1 of crystalloid fluid preload over 20 min or to receive no fluids before induction of anaesthesia. A significant decrease in systolic arterial pressure (< 75% of baseline value) occurred in both the fluid-loaded and the control groups, and was similar in both groups. Administration of a fluid preload did not attenuate the decrease in systolic arterial pressure after induction of anaesthesia with propofol and fentanyl.

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Section: Discussionmentioning

confidence: 99%

Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl

Turner¹,

Gatt²,

Kam³

et al. 1998

British Journal of Anaesthesia

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“…Whilst the mean CVP achieved after preload in the 10-min group was within clinically acceptable ranges, three patients had values which caused concern (16, 19 and 19 mm Hg). In 1966, Askrog was unable to demonstrate any untoward effects of infusing 1000 ml over 4 min and only a transient increase in pulmonary artery pressure, although his subjects were receiving halothane anaesthesia and were not pregnant [2]. There is evidence to suggest that parturients might be more susceptible to pulmonary oedema after rapid administration of crystalloid solutions, possibly because of an increase in lung water during pregnancy witfi a reduced pulmonary interstitial safety margin [3].…”

Section: Discussionmentioning

confidence: 99%

Rapid Administration of Crystalloid Preload Does Not Decrease the Incidence of Hypotension After Spinal Anaesthesia for Elective Caesarean Section

Rout

Akoojee

Rocke

et al. 1992

British Journal of Anaesthesia

136

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Twenty parturients undergoing elective Caesarean section were allocated randomly to receive crystalloid preload 20 ml kg-1 over either 20 min or 10 min before spinal anaesthesia. Significant hypotension (systolic arterial pressure less than 100 mm Hg and less than 80% of baseline value) occurred in six of the 10 patients in the 20-min preload group and seven of 10 patients in the 10-min preload group (ns). Both groups had a significant (P less than 0.05) increase in central venous pressure during the preload period. The mean central venous pressure in the 10-min group was 11.9 mm Hg (range 6-19 mm Hg), which was significantly greater (P less than 0.05) than that in the 20-min group (mean 7.3 mm Hg, range 2-13 mm Hg). Three patients in the 10-min group had clinically unacceptable increases in central venous pressure. This study has demonstrated that rapid administration of crystalloid preload before spinal anaesthesia did not decrease the incidence or severity of hypotension, and questions the role of crystalloid preload.

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The Cardiovascular Response of Normal Anaesthetized Man to Rapid Infusion of Saline

Cited by 2 publications

References 0 publications

Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl

Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl

Rapid Administration of Crystalloid Preload Does Not Decrease the Incidence of Hypotension After Spinal Anaesthesia for Elective Caesarean Section

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