The cardiopulmonary system: research and training opportunities

Jobe, Alan H.

doi:10.1038/sj.jp.7211522

Cited by 5 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of inotropic intervention in the preterm neonate is not well-described, leading to a tenfold variation in inotropic intervention between neonatal units 7. Research to enhance understanding of neonatal circulatory failure is a priority 5 8…”

mentioning

confidence: 99%

Functional cardiac MRI in preterm and term newborns

Groves

Chiesa

Durighel

et al. 2010

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

ObjectiveTo use cardiac MRI techniques to assess ventricular function and systemic perfusion in preterm and term newborns, to compare techniques to echocardiographic methods, and to obtain initial reference data.DesignObservational magnetic resonance and echocardiographic imaging study.SettingNeonatal Unit, Queen Charlotte's and Chelsea Hospital, London, UK.Patients108 newborn infants with median birth weight 1627 (580–4140) g, gestation 32 (25–42) weeks.ResultsMean (SD) flow volumes assessed by phase contrast (PC) imaging in 28 stable infants were left ventricular output (LVO) 222 (46), right ventricular output (RVO) 219 (47), superior vena cava (SVC) 95 (27) and descending aorta (DAo) 126 (32) ml/kg/min, with flow being higher at lower gestational age. Limits of agreement for repeated PC assessment of flow were LVO ±50.2, RVO ±55.5, SVC ±20.9 and DAo ±26.2 ml/kg/min. Mean (SD) LVO in 75 stable infants from three-dimensional models were 245 (47) ml/kg/min, with limits of agreement ±58.3 ml/kg/min. Limits of agreement for repeated echocardiographic assessment of LVO were ±108.9 ml/kg/min.ConclusionsDetailed magnetic resonance assessments of cardiac function and systemic perfusion are feasible in newborn infants, and provide more complete data with greater reproducibility than existing echocardiographic methods. Functional cardiac MRI could prove to be a useful research technique to study small numbers of newborn infants in specialist centres; providing insights into the pathophysiology of circulatory failure; acting as an outcome measure in clinical trials of inotropic intervention and so guiding clinical practice in the wider neonatal community.

show abstract

mentioning

confidence: 99%