The Cardioprotective Effects of Semaglutide Exceed Those of Dietary Weight Loss in Mice With HFpEF

Natriuretic peptides – Biomarker companions through thick and thin

“…Importantly, this was accompanied by a 20% reduction in NT‐proBNP (median baseline NT‐proBNP 451 ng/L), while ‘pure’ weight loss induced by bariatric surgery had previously been shown to result in an increase in NP 13 . This strongly suggests that semaglutide leads to very meaningful cardiac effects, which is in line with recent experimental data 14 . Importantly, SGLT2i also induce cardiac effects but more modest reductions in NT‐proBNP 15 and weight than GLP‐1 receptor agonists.…”

“…13 This strongly suggests that semaglutide leads to very meaningful cardiac effects, which is in line with recent experimental data. 14 Importantly, SGLT2i also induce cardiac effects but more modest reductions in NT-proBNP 15 weight reduction but also more profound cardiac effects than SGLT2i. It is therefore of utmost importance to identify obese HFpEF patients who derive the greatest benefit from a GLP-1 receptor agonist on top of SGLT2i therapy given the high costs and the worldwide shortage of GLP-1 receptor agonists.…”

Anti-inflammatory benefits of semaglutide: State of the art

“…Furthermore, semaglutide has been found to ameliorate obesity-induced inflammation by down-regulating S100a8, S100a9, and Cxcl2 in neutrophils of obese mice [62] , [80] . It has also demonstrated a reduction in obesity-dependent inflammation in obese mice [91] . These effects may represent additional molecular links between semaglutide and the reduction of inflammation.…”

“…These anti-inflammatory effects have resulted in pro-thrombotic, anti-atherosclerotic, and anti-atherogenic benefits in animal [66] , [79] , [86] and human [67] , [80] studies. Furthermore, semaglutide may improve vascular structure and preserve endothelial permeability by normalizing the elements involved in the extracellular matrix and cytoskeleton, such as Coll5a1, Lama4, and Sparc [91] , [92] . Therefore, it appears that semaglutide may protect the cardiovascular system, improve cardiac function, and promote ventricular thickening through its anti-inflammatory effects ( Fig.…”

Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture

“…Animal studies also showed that treatment with semaglutide induces a wider array of favorable cardiometabolic effects than does weight loss induced by pair feeding. 15 In addition, the GLP-1 receptor was found to be present in the chemosensory cells of the carotid body, and its pharmacological activation led to lower discharge by the basal carotid artery, in association with attenuation of the blood pressure and sympathetic responses evoked by the chemoreflex. 16 Thus, the cardiovascular benefits of semaglutide are likely related, at least in part, to its ability to specifically target the pathobiology of cardiovascular disease.…”