The Cardiomyopathies

Hosenpud, Jeffrey D.

doi:10.1007/978-1-4613-8315-4_13

Cited by 8 publications

(3 citation statements)

References 202 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dilated cardiomyopathies are a classification of primary myocardial disease states which constitute a significant proportion of patients with heart failure (167,341,510). While the etiologies for dilated cardiomyopathy (DCM) are diverse, a general pathophysiological classification scheme has been developed and termed ischemic, idiopathic (nonischemic), or infectious.…”

Section: Myocardial Remodeling In Cardiomyopathic Diseasementioning

confidence: 99%

Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

Spinale¹

2007

Physiological Reviews

1,006

1,023

View full text Add to dashboard Cite

It is now becoming apparent that dynamic changes occur within the interstitium that directly contribute to adverse myocardial remodeling following myocardial infarction (MI), with hypertensive heart disease and with intrinsic myocardial disease such as cardiomyopathy. Furthermore, a family of matrix proteases, the matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs), has been recognized to play an important role in matrix remodeling in these cardiac disease states. The purpose of this review is fivefold: 1) to examine and redefine the myocardial matrix as a critical and dynamic entity with respect to the remodeling process encountered with MI, hypertension, or cardiomyopathic disease; 2) present the remarkable progress that has been made with respect to MMP/TIMP biology and how it relates to myocardial matrix remodeling; 3) to evaluate critical translational/clinical studies that have provided a cause-effect relationship between alterations in MMP/TIMP regulation and myocardial matrix remodeling; 4) to provide a critical review and analysis of current diagnostic, prognostic, and pharmacological approaches that utilized our basic understanding of MMP/TIMPs in the context of cardiac disease; and 5) most importantly, to dispel the historical belief that the myocardial matrix is a passive structure and supplant this belief that the regulation of matrix protease pathways such as the MMPs and TIMPs will likely yield a new avenue of diagnostic and therapeutic strategies for myocardial remodeling and the progression to heart failure.

show abstract

Section: Myocardial Remodeling In Cardiomyopathic Diseasementioning

confidence: 99%

Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

Spinale¹

2007

Physiological Reviews

1,006

1,023

View full text Add to dashboard Cite

show abstract

“…The mechanism(s) of transition from compensatory remodeling to decompensatory heart failure in cardiomyopathy is unclear [Grossman et al, 1975; Tyagi et al, 1996a; Lorell, 1997]. The consequence of various types of cardiomyopathies is associated with a decrease in cardiac muscle contractile function [WHO‐ISFC, 1980; Manolio et al, 1992; Hosenpud, 1994]. The extracellular matrix (ECM) surrounding the cardiac muscle plays an important role in regulating muscle contraction and relaxation [Watson, 1991; Tyagi, 1997].…”

mentioning

confidence: 99%

Expression and role of Roundabout‐1 in embryonic Xenopus forebrain

Connor

Key

2002

Developmental Dynamics

View full text Add to dashboard Cite

ABSTRACT.The receptor Roundabout-1 (Robo1) and its ligand Slit are known to influence axon guidance and central nervous system (CNS) patterning in both vertebrate and nonvertebrate systems. Although Robo-Slit interactions mediate axon guidance in the Drosophila CNS, their role in establishing the early axon scaffold in the embryonic vertebrate brain remains unclear. We report here the identification and expression of a Xenopus Robo1 orthologue that is highly homologous to mammalian Robo1. By using overexpression studies and immunohistochemical and in situ hybridization techniques, we have investigated the role of Robo1 in the development of a subset of neurons and axon tracts in the Xenopus forebrain. Robo1 is expressed in forebrain nuclei and in neuroepithelial cells underlying the main axon tracts. Misexpression of Robo1 led to aberrant development of axon tracts as well as the ectopic differentiation of forebrain neurons. These results implicate Robo1 in both neuronal differentiation and axon guidance in embryonic vertebrate forebrain.

show abstract

“…Cardiac manifestations include conduction system disease and arrhythmias; sudden cardiac death is a recognized complication, and pacemaker placement is often necessary. However, DCM is extremely uncommon in patient with limb girdle muscular dystrophy [2,4,5]. Recently, it has been reported using echocardiography that 3 of 42 patients with merosin-positive congenital muscular dystrophy related to the autosomal recessive limb girdle muscular dystrophy has ejection fraction between 50% and 55%, suggesting the existence of left ventricular dysfunction [6].…”

Section: Discussionmentioning

confidence: 98%